Acute axonal damage predicts clinical outcome in patients with multiple sclerosis (original) (raw)

Multiple Sclerosis, 2005

Abstract

The objectives of this study were (1) to determine how cerebrospinal fluid (CSF) neurofilament heavy chain (NfHSMI34 and NfHSMI35) levels relate to clinical outcome in optic neuritis (ON) and multiple sclerosis (MS) relapse patients treated with high dose oral methylprednisolone; and (2) to correlate neurofilament and myelin basic protein (MBP) concentrations, particularly as the latter was previously associated with clinical disability. Fifty subjects participated in two double-blind, randomized, placebo-controlled clinical trials. Eight/18 patients in the ON trial and 15/32 subjects in the MS attack trial were treated with oral methylprednisolone. In the MS attack trial group, CSF NfHSMI34 and NfHSMI35 measured at week 3 and DCSF NfHSMI34 levels from baseline to week 3 were predictive of clinical outcome at week 8 and 52. In the ON group, no such association was seen. When both groups were combined, baseline CSF NfHSMI34 and NfHSMI35 correlated positively with baseline enhancing l...

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