Capacity of Mentha spicata (spearmint) Extract in Alleviating Hormonal and Folliculogenesis Disturbances in Polycystic Ovarian Syndrome Rat Model (original) (raw)
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Advanced pharmaceutical bulletin, 2017
Given the antiandrogenic effects of spearmint, in this study we evaluated the effects of its essential oil on polycystic ovarian syndrome in a rat model.Female rats were treated as follows: Control, normal rats which received 150 mg/kg spearmint oil or 300 mg/kg spearmint oil, or sesame oil; and PCOS-induced rats which received 150 mg/kg spearmint oil or 300 mg/kg spearmint oil, or sesame oil. Then the animals were killed and the levels of LH, FSH, testosterone and ovarian folliculogenesis were evaluated.Spearmint oil reduced body weight, testosterone level, ovarian cysts and atretic follicles and increased Graafian follicles in PCOS rats.Spearmint has treatment potential on PCOS through inhibition of testosterone and restoration of follicular development in ovarian tissue.
Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is a complex reproduction and endocrine disorder of women in the reproductive age. Spearmint (Mentha spicata L.) has anti-androgenic activity and flaxseed (Linum usitatissimum L.) contains phytoestrogen and was reported to improve PCOS conditions. This study aimed to evaluate PCOS conditions following administration of a mixture of these two plants. Methods Twenty-four rats with regular cycles were randomly divided into four groups as control (C) and treatment-control (TC) received a combination of spearmint extract (SE) + flaxseed extract (FE). PCOS was induced in PCOS and treatment (T) groups by a single intramuscular injection of estradiol valerate. The treatment group received a combination of SE and FE for 30 days, 7 weeks after injection of estradiol valerate. Estrous cycles were monitored for 10 days and in the last day animals were sacrificed, ovaries were collected for the histomorphometric study and the serum levels of progestero...
Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism
Phytotherapy Research, 2007
Mentha spicata Labiatae, known as spearmint and Mentha piperita Labiatae, known as peppermint can be used for various kinds of illnesses in herbal medicine and flavoring in industry. M. spicata Labiatae grows on the Anamas plateau of Yeniparbademli town of Isparta, located in southwest part of Turkey. In this town, clinicians thought that consumption of tea steeped with M. spicata or M. piperita caused a diminished libido. Because antiandrogenic effects of spearmint and peppermint were found previously in rats, it was decided to observe the effect of this herbal tea on the androgen levels in hirsute women.
Polycystic Ovary Syndrome (PCOS) is a common condition of infertility in females and its major hallmark features are hyperandrogenemia and hyperinsulinemia. Menthapiperita (peppermint) has antiandrogenic properties in both animals and women. This study aims to evaluate the protective role ofpeppermint on Letrozole induced PCOS in female rats. 40 Wistar female rats were divided into 5 groups of 8 each. G1: served as a control group. G2 (vehicle):rats were daily received oral doses of 2ml/kgb.w. of 1% carboxymethylcellulose for 3 weeks. G3:rats were daily administered oral doses of 1mg/kg b.w. of letrozole for 3 weeks. G4:rats were treated with letrozole for 3 weeks to induce PCOS& supplemented with peppermint (40g/L) for further 3 weeks. G: rats were treated with letrozole plus peppermint for 3 weeks. After the treatment, the rats were killed; uteri and ovaries then excised and weighed. Serum hormone levels and histological changes in ovaries & uteri were examined.The results revealed that PCOS-females exhibited marked alterations in serum testosterone, estrogen, LH and FSH activity. PCOS group showed ovarian cysts with a diminished granulosa layer, atretic follicles and a few number of corpora lutea. Also, PCOS group induced massive alterations in the uterine tissue manifested by necrosis in stromal mesenchymal cells, hyperplasia of luminal epithelial cells. All these alterations in ovarian & uterine tissues were ameliorated by supplementation with peppermint. In conclusion, the peppermint found to have a good potential as alternative therapy in the treatment of PCOS.
Induction and Treatment of Polycystic Ovary Syndrome with Plant Extract in Rats: A Systematic Review
European journal of medicinal plants, 2023
Aims: To review the induction and treatment of polycystic ovarian syndrome (PCOS) with plant extract in rats in light of the rising incidence of the condition, its accompanying physical and mental issues, and the role that sex hormone alterations play in its development. Methodology: An extensive literature search was carried out using relevant publications, which were published between 2012 and 2022 and indexed in Google Scholar, PubMed, Elsevier, Scientific Information Database, and Science Direct were investigated. Results: This review shows that the majority of research examined the levels of sex hormones in the serum, the induction of PCOS, and the treatment of animal models. The review also found that Systematic Review Article
Journal of Ethnopharmacology, 2002
The present study was undertaken to assess the reversible contraceptive efficacy of methanolic extract of Mentha ar6ensis leaves. Aqueous solution of the extract (10 mg per day per mouse) when administered orally to male mice of proven fertility for 20, 40 and 60 days caused inhibition of fertility while maintaining their normal sexual behaviour. With the increase in treatment duration, there occurred a corresponding decrease in the mean weight of testis and accessory organs of reproduction. Sperm concentration, motility and viability in the cauda epididymis were also decreased. Spermatozoa with coiled tails also appeared in the epididymal smear. However, all the induced effects returned to normalcy within 30 days following withdrawal of 60-day treatment. Oral administration of the extract also did not affect the body weight of the mice and their blood cells count, packed cell volume, haemoglobin and blood/serum biochemistry.
r e p r o d c l i m. 2 0 1 7;3 2(2):109–119 h t t p : / / w w w. s b r h. o r g. b r / r e v i s t a a b s t r a c t Medicinal plants are known as a prolific source of secondary metabolites which have important function both in vivo and in vitro during the ovarian folliculogenesis and steroidogenesis in many animal species. Some secondary metabolites can act as antioxidants generally through their ability to scavenge reactive oxygen species (ROS) or can regulate ovarian hormonal production. In general, these properties are responsible for the medicinal functions to treat woman infertility disorder. Some plants are constituted of biological actives substances which have been used to treat reproductive dysfunction. However, until recently, little was known about the implication of plants and/or their secondary metabolites on in vitro folliculogenesis and steroidogenesis. With the development of the technology, there is an increase implication of those substances in assisted reproductive technology (ART). The present review highlights some medicinal plants used in the treatment of woman disorders related to infertility. In addition, it provides an in vivo and in vitro overview of herbs and their active compounds with claims for improvement of ovarian activity thus showing their implication in female reproductive health care. Relatos sobre a contribuição in vivo e in vitro de plantas medicinais na melhora da função reprodutiva feminina Palavras-chave: Fitoterapia Antioxidantes r e s u m o Sabe-se que as plantas medicinais são uma fonte abundante de metabólitos secundários que têm função importante tanto in vivo quanto in vitro durante a foliculogênese e a esteroidogênese ovarianas em muitas espécies animais. Alguns metabólitos secundários
Toxicology Research, 2022
Mentha longifolia L (ML) is locally used as an herbal contraceptive. We aim to assess the toxicity profile and validate the antifertility effects of its leaves in male rats. Adult male Sprague Dawley rats (n = 10 animals/group) were divided into four groups. The Control group received .9% saline, while groups II, III, and IV received 50, 75, and 100 mg/kg/day ML doses for 28 days. ML induced a dosedependent decrease in percent fertility as well as the number of pups born in ML preexposed pairs, with maximum change observed in the ML3 group (60%, 3.75 ± 1.25) as compared to control (100%, 8.75 ± .48) group. A significant (P < .01) decrease in the rate of daily sperm production was observed in the ML3 group (.86 ± .16) in contrast to the control (2.93 ± .05). The levels of catalase and superoxide dismutase declined significantly in treatment groups (ML1-P < .001, ML2-P < .05, and ML3-P < .01). A significant increase in the production of reactive oxygen species (P < .001) was found in all treatment groups. The concentrations of LH (P < .001), FSH (P < .001), and testosterone (P < .001) were significantly reduced in a dose-dependent manner among ML-treated groups. Decreases in spermatogonial populations, mature spermatids, seminiferous tubule diameter, lumen diameter, and epithelial height were noticed at higher doses. The reversibility study depicted a reduction in both pregnancy outcomes and litter size. Besides contraceptive effects, M. longifolia L usage is associated with oxidative stress; therefore, it is important to consume this herb appropriately and its excessive usage should be prohibited.
Health benefits and effects of selected herbal plants on mammalian reproductive system : A review
Science Letters, 2014
This article aims at reviewing the health benefits and potential effects of selected herbal plants which included Averrhoa bilimbi, Cosmos caudatus and Pereskia bleo on mammalian reproductive systems. All these three herbal plants under study are enriching with potent anti-oxidant, anti-microbial and anti-carcinogen properties that are crucial in maintaining well-being. Averrhoa bilimbi has shown to increase infertility rate in adult female mice by using 14.4 ml/kg body weight of extracted Averrhoa bilimbi juice. Cosmos caudatus able to take action as therapeutic agent and repair bone damage in elderly women which phytoestrogens contains in it can mimic the effects of estrogen. Cosmos caudatus is reported to exhibit radical-scavenging activity which important to maintaining the production of quality sperm. Recognized for its anti-proliferation and cytotoxic activity that attacks a few human cancer cell lines, Pereskia bleo showed the ability to protect the normal mouse fibroblast cells from the natural or oxidant-induced cell death caused by programmed cell death or apoptosis.