Time-related effect of P2Y12 inhibitors pre-treatment in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (original) (raw)

C103 TIME-RELATED EFFECT OF P2Y12 INHIBITORS PRE-TREATMENT IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION Valeria Paradies1, Martino Pepe1, Alessandro Cafaro1, Filippo Masi1, Marco Basile1, Fortunato Iacovelli1, Domenico Zanna1, Gianluca Camarda2, Donato Quagliara1, Riccardo Guglielmi2, Stefano Favale1 1Dipartimento di Cardiologia Universitaria, Policlinico di Bari, Bari, Italy, 2Dipartimento di Cardiologia Ospedaliera, Policlinico di Bari, Bari, Italy The goal of ST-segment elevation myocardial infarction (STEMI) treatment is early reperfusion. Clopidogrel and new P2Y12 inhibitors, ticagrelor and prasugrel, demonstrated to improve angiographic results of primary PCI (pPCI) and 30-days MACE. Conversely antiplatelet inhibition increases bleeding; immediate CABG amounts for 3-4% of STEMI population with a not negligible major bleeding rate of 19%. Cause P2Y12 inhibitors has a delayed effect due to intestinal abso...