PHARMACOKINETIC STUDY OF PHENYTOIN IN MALAYSIAN PEDIATRIC PATIENTS AT PENANG HOSPITAL (original) (raw)

This study investigates the pharmacokinetics of phenytoin in Malaysian pediatric patients, focusing on the estimation of key pharmacokinetic parameters (Vmax and Km) and their correlation with demographic factors such as age, race, and serum albumin levels. The research involved retrospective data collection from 75 pediatric patients diagnosed with epilepsy, revealing significant differences in KM values between races, while Vmax remained consistent across groups. The findings highlight the importance of individual pharmacokinetic profiles in optimizing phenytoin therapy for pediatric patients.