Inhibition of gastric acid secretion is a probable mechanism underlying the anti-ulcer activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg (original) (raw)
Related papers
Journal of Ethnopharmacology, 2006
The hydroethanolic extract of the leaves (HEL) and bark (HEB) obtained from Alchornea castaneaefolia (Euphorbiaceae) were investigated for their ability to prevent ulceration of the gastric mucosa in animal models. HEL (500 and 1000 mg/kg) and HEB (1000 mg/kg) significantly reduced the gastric injuries induced by the combination of HCl/ethanol and lowered the severity of gastric damage formation induced by indomethacin/bethanechol in mice. Further investigation showed that HEL also inhibited formation of ulcers in mice submitted to stress and pylorus ligature, but HEL did not modify gastric juice parameters in Shay mice. HEL was also effective in promoting the healing process in chronic gastric ulcer induced by acetic acid in rats. An enriched flavonoidic fraction (EFF at dose of 100 mg/kg) obtained from HEL reduced gastric lesions induced by HCl/ethanol and indomethacin/bethanechol in mice. Although EFF did not modify the amount of free mucus production by gastric mucosa, it was able to increase prostaglandin production. When administered to rats submitted to ethanol-induced gastric lesions, EFF increased the somatostatin serum levels, while the gastrin serum levels were proportionally decreased. Phytochemical investigation on HEL and EFF led to the isolation of flavonoids glycosides as the main compounds, thus suggesting that these substances may be involved in the observed antiulcer activity.
Effects of the Ethyl Acetate Fraction of Alchornea triplinervia on Healing Gastric Ulcer in Rats
Pharmaceuticals, 2011
Alchornea triplinervia (Spreng.) Muell. Arg (Euphorbiaceae) is a medicinal plant commonly used by people living in the Cerrado region of Brazil to treat gastrointestinal ulcers. We previously described the gastroprotective action of methanolic extract (ME) of Alchornea triplinervia and the ethyl acetate fraction (EAF) in increasing of prostaglandin E 2 (PGE 2) gastric levels in the mucosa. In this work we evaluated the effect of EAF in promoting the healing process in rats with acetic acid-induced gastric ulcers. In addition, toxicity was investigated during treatment with EAF. After 14 days of treatment with EAF, the potent stimulator of gastric cell proliferation contributed to the acceleration of gastric ulcer healing. Upon immunohistochemical analysis, we observed a pronounced expression of COX-2, mainly in the submucosal layer. The 14-day EAF treatment also significantly increased the number of neutrophils in the gastric mucosa regeneration area. The EAF induced angiogenesis on gastric mucosa, observed as an increase of the number of blood vessels supplying the stomach in rats treated with EAF. Oral administration for 14 days of the ethyl acetate fraction from Alchornea triplinervia accelerated the healing of gastric ulcers in rats by promoting epithelial cell proliferation, increasing the number of neutrophils and stimulation of mucus production. This fraction, which contained mainly phenolic compounds, contributed to gastric mucosa healing.
IN VIVO GASTRO-PROTECTIVE EFFECTS OF FIVE MOROCCAN MEDICINAL PLANTS AGAINST GASTRIC ULCER
Centaurea chamaerhaponticum Ball. (Asteraceae), Lawsonia inermis L. (Lythraceae), Origanum compactum Benth. (Lamiaceae), Punica granatum L. (Punicaceae) and Ceratonia siliqua L. (Sapindaceae) are medicinal plants recommended in Moroccan folk medicine for the treatment of gastric ulcers. The protective effects of the studied plants against gastric damage were investigated using three experimental models in rats (HCl/ethanol, pylorus ligation, and aspirin-induced ulcer). Each plant extract (250 or 500 mg/kg) was orally administered once prior to ulcer induction. The antiulcer activity was assessed by comparing the ulcer index and gastric parameters in the test group with those of the control group. As a result, all five plant extracts showed, at the high dose, a significant gastro-protective effect. O. compactum showed the highest ulcer protective in NSAID-induced ulcer model (86.1 % of protection), greater than that of omeprazole (79.7 %) and almost similar to that of cimetidine (84.8%). The volume of gastric secretion was decreased significantly by C. chamaerhaponticum (50% of gastric secretion reduction), C. siliqua (46.4%) and L. inermis (42.8%) similarly to omeprazole’s antisecretory effect (50% of secretion reduction). A significant decrease in the total acidity was noticed only at the highest dose for all tested plants (percent of total acidity reduction ranged from 22.2 to 30.5 %), except for C. chamaerhaponticum which showed no significant modifications in both total acidity and gastric pH. Taken together, the results of this study indicate that the selected plants possess potent gastroprotective and antisecretory properties, which justify the ethno-medicinal claims.
Journal of Applied and Natural Science
Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively. Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing it...
Albizzia lebbeck Benth (Family Mimoseaceae) is used traditionally in Indian System of Medicine for various ailments. Present study aims at the gastroprotective effect ethylacetate and saponin fraction of Albizzia lebbeck bark which were administered orally as pretreatment for ethanol (EtOH), cold-restraint stress (CRS) and pylorus ligation (PL) induced ulcers. Estimation of gastric secretion parameters like volume of gastric juice, acid output, and pH value were estimated in PL induced ulcer model. The results of our study revealed that Albizzia lebbeck bark ethylacetate extract showed dose-dependent ulcer protective effect on peptic ulcers induced by physical and chemical agents in rodents.
AN REVIEW ARTICLE ON THE ANTI-ULCER ACTIVITY OF SOME MEDICINAL PLANTS
Peptic ulcer is one of the most common gastrointestinal diseases. The exact causes of peptic ulcer disease are not known but it may be result from an imbalance between acid-pepsin secretion and mucosal defence factors. Peptic ulcer disease occurs mainly due to consumption of NSAIDs, infection by H. pylori, stress, or due to a pathological condition such as Zollinger –Ellison Syndrome. Nature provides a number of medicines and perhaps all solutions for human illnesses. So far, nature supplies many clinically useful drugs. Ulcer is a major increasing health problem. Nowadays, there are several synthetic medications available for the treatment of peptic ulcers, but these drugs are expensive and are likely to produce more side effects than herbal drugs. Certain antiulcer drugs such as proton pump inhibitors and H2 receptor antagonists are used to treat peptic ulcers. However, these drugs have shown disease relapse, side effects, and even drug interactions. Numerous medicinal plants have anti-ulcer activity and are useful in the treatment of peptic ulcers. The aim of this review is to find out more about the anti-ulcer properties of herbal medicines. The present article reviews the antiulcerogenic and ulcer healing property of Ocimum sanctum, Allophylus serratus, Desmodium gagenticum, Azadirachta indica, Hemidesmus racemosus, Asparagus racemosus, and Musa sapientum. We have brought to light some of the important plants reported for their anti-ulcer and ulcer healing properties. Ayurvedic knowledge supported by modern science is necessary to isolate, characterize and normalize the active components of herbal sources for antiulcerative activity. KEYWORDS: Antiulcer activity, Ethanolic extract, Aspirin-induced ulcer model, NSAIDs.
Anti-Ulcer Activity Of Medicinal Plants
International Journal of Pharmaceutical Sciences, 2023
The most prevalent digestive tract condition, peptic ulcers are primarily caused by an imbalance between aggressive and defensive stomach forces. Because of their hectic lifestyles, industrialised, civilised, and developed nations have higher rates of ulcers. Medicinal plants: crucial and productive Plant with so many amazing health benefits that very little of the human body is left. Unaffected by its therapeutic application. It is a significant and potent anti-ulcer. The anti-ulcer properties of herbal Recipe for aloe vera. Recognition and application Herbal remedies with ulcer-preventing properties. A substantial amount Communities now depend on these medicinal herbs since they are inexpensive, generally safe, and have no Negative outcome. A common gastrointestinal ailment that many people experience is ulcers. In essence, it is an inflammatory tear in the skin or the mucous lining the stomach. When there is a disruption of the natural equilibrium brought on by increased aggression or decreased mucosal Opposition. It could be brought on by consistent drug use, erratic eating patterns, stress, and other factors. Peptic Ulcers are a general term that encompasses stomach or duodenal ulcers of the digestive tract. The Peptic ulcer development is dependent on the presence of acid and peptic activity in the stomach contents in addition to a Breach of the mucosal barrier. There are several synthetic medications available to treat ulcers. However, these medications Are costly and probably Key words:- presentation methods, Antiulcer Activity, medicinal plants, gastro intestinal
Combined Effects of Medicinal Plants on Induced Upper Gastrointestinal Tract Injury in Wistar Rats
Ethiopian Journal of Health Sciences, 2016
BACKGROUND: Herbal medicines are now recently used as treatment options. This study was conducted to determine the effect of the combination therapy of medicinal herbs in the treatment of induced gastrointestinal injury among albino wistar rats. METHODS: A total of 60 Albino Wistar rats of both sexes weighing between 130g-150g were used. The control groups which consisted of negative control groups received 1ml of normal saline while the positive control group was given 20mg/kg of indomethacin and sacrificed after 6 hours. Those in the test group were given 20mg/kg of indomethacin, treated in different doses of single and combined extracts of Allium sativum, Brassica oleracea and Aloe barbadensis at 100mg/kg, 200mg/kg and 300mg/kg body weights, twice daily for 8 days and sacrificed. RESULTS: There was no visible sign of ulceration or perforation observed on the stomach and duodenum when compared with the control. The combination of all three plant extracts at different concentrations ranging from 100-300mg/kg cleared all visible ulcers and perforations on the stomach of wistar rats. Similarly, all ulcers in the duodenum of indomethacin induced wistar rats were cleared by the combination of the three extracts. The sections of rat stomach and duodenum given 100mg/kg herbal cocktail and indomethacin showed normal mucosa. CONCLUSIONS: A mixture of the three herbs at 300mg/kg was better in healing gastric and duodenal ulcers. The mixture of the three plants extracts exhibit good anti-ulcer activity that warrants further studies.
2019
For the treatment of gastric ulcer and duodenal ulcer, a number of drugs is used with a wide range of effects anti-inflammatory, reparative, analgesic, hemostatic activities. Considering that most of them are synthetic with a significant number of side effects and a number of contraindications, the alternative is to search for new drugs, including plant origin. A well-known medicinal plant rosebay willow herb (Chamaenerion angustifolium L.), which contains a significant amount of phenolic compounds (tannins, flavonoids, hydroxycinnamic acids) is an object of interest. According to the literature, it is used in traditional medicine for treatment of gastric ulcer. It was experimentally established that lyophilized extract of rosebay willow at dose 20 mg/kg proved a significant gastroprotective effect in model of simulated erosive and haemorrhagic gastric mucosa damage caused by acetylsalicylic acid. In cases of administration of lyophilized extract of rosebay willow, the severity of i...