Spectroscopic, Structural and Antibacterial Activity of Mixed Ligand Complexes from Schiff Base with Anthranilic Acid Spectroscopic, Structural and Antibacterial Activity of Mixed Ligand Complexes from Schiff Base with Anthranilic Acid (original) (raw)
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Bidentate Schiff base ligand 3-(3,4-Dihydroxy-phenyl)-2-[(4-dimethylaminobenzylidene)-amino]-2-methyl-propionic acid was prepared and characterized by spectroscopic techniques studies and elemental analysis. The Cd(II), Ni(II), Cu(II), Co(II), Cr(III),and Fe(III) of mixed-ligand complexes were structural explicate through moler conductance , [FT-IR, UV-Vis & AAS], chloride contents, , and magnetic susceptibility measurements. Octahedral geometries have been suggested for all complexes. The Schiff base and its complexes were tested against various bacterial species, two of {gram(G+) and gram(G-)} were shown weak to good activity against all bacteria
2021
2,2’-((1Z-1’Z) (1,3-diphenylpropane-1,3-diylidene) bis (azanylylidene)) dibenzoic acid (H2L) Schiff base ligand, was obtained by condensation reaction between anthranilic acid and dibenzoyl methane in 2:1 ratio.A series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes was resulted from 1:1 (ligand: metal salt) reaction.The structural features of the synthesized ligand and its metal complexes was determined by elemental analyses, IR, 1H NMR, UV-Vis, ESR, mass spectra, conductivity and magnetic susceptibility measurements as well as thermal (TG/DTG) analyses. The analytical and spectroscopic tools showed that the complexes had composition of ML type with octahedral geometry. The IR results confirmed the tetradendate binding of the ligand involving two azomethine nitrogen atoms and two carboxylate oxygens. The Schiff base and its complexes have been screened for their antimicrobial activity against several bacterial organisms as (Streptococcus pneumoniae...
The Pharma Innovation Journal, 2016
The new bidentate Schiff base ligand namely [(E)-N 1-(4-methoxy benzylidene) benzene-1, 2-diamine] was prepared from condensation of 4-Methoxy benzaldehyde with O-Phenylene diamine at 1:1 molar ratio in ethanol as a solvent in presence of drops of 48% HBr. The structure of ligand (L) was characterized by, FT-IR, U.V-Vis., 1 H-, 13 C-NMR spectrophotometer, melting point and elemental microanalysis C.H.N. Metal complexes of the ligand (L) in general molecular formula [M(L)3], where M= Mn(II), Co(II), Ni(II),Cu(II) and Hg(II); L=(C14H14N2O) in ratio (1:3)(Metal:Ligand) were synthesized and characterized by Atomic absorption, FT-IR, U.V-Vis. spectra, molar conductivity, chloride content, melting point and magnetic susceptibility from the above data the geometrical formula was octahedral for all complexes. And in vitro tests for antibacterial activity showed that most of the prepared compounds display activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeruginosa).
2021
Schiff base ligands were synthesis via a condensation of the ligands in methanol in 1:1:1 molar ratio reactions. The transition metal(II) complexes were formed by the reaction of Co, Cu, Mn, Fe with the Schiff base and ampicillin and they were characterized via FTIR, electronic spectra, melting points, solubility and molar conductance. The invitro antibacterial activities of the complexes were tested using four bacterial strains; gramnegative; (Escherichiacoli, salmonellatyphi) and grampositive; (staphylococcus pyogenes and staphylococcus aureus). The complexes were formed in good yield and they have various shades of colors and sharp melting points. The IR spectrum of the HL (Table4) displays a new at (1651) cm-1 which is due to υ(HC=N) group of the azomethine stretching vibrations of the ligand, on complexation these band has been shifted to lower frequencies (1651), (1621), (1651), and (1627)cm-1 for complexes [Co(Ampi)(3AMPB)Cl], [Cu(Ampi)(3AMPB)], [Mn(Ampi)(3AMP)Cl] and [Fe(Amp...
In this research, new mixed ligand Schiff base complexes of Mn(II), Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) are formulated from the Schiff base (L) resulting from o-phathalaldehyde (o-PA) with p-nitroaniline (p-NA) as a primary ligand and anthranilic acid as a subordinate ligand. Diagnosis of prepared ligand and its complexes is done by spectral methods as mass spectrometer; 1 H-NMR for ligand Schiff base FTIR, UV-Vis, molar conductance, elemental microanalyses, atomic absoption and magnetic susceptibility. The analytical studies for the all new complexes have shown octahedral geometries. The study of organicperformance of ligand Schiff base and its complexes show various activity agansit four type of bactria two gram (+) and two gram (-) .
Metal complexes of Schiff base: Preparation, characterization and antibacterial activity
A total of five new metal complex derivatives of 2N-salicylidene-5-(p-nitro phenyl)-1,3,4thiadiazole, HL with the metal ions Vo(II), Co(II), Rh(III), Pd(II) and Au(III) have been successfully prepared in alcoholic medium. The complexes obtained are characterized quantitatively and qualitatively by using micro elemental analysis, FTIR spectroscopy, UV-Vis spectroscopy, mass spectroscopy, 1 H & 13 C NMR, magnetic susceptibility and conductivity measurements. From the spectral study, all the complexes obtained as monomeric structure and the metals center moieties are four-coordinated with square planar geometry except VO(II) and Co complexes which existed as a square pyramidal and tetrahedral geometry respectively. The preliminary in vitro antibacterial screening activity revealed that complexes 1-5 showed moderate activity against tested bacterial strains and slightly higher compared to the ligand, HL.
Medical Laboratory Journal, 2017
Background and objectives: Synthesis and characterization of several metal complexes (metal ions: Co 2+ , Ti 4+ and Ce 3+) of macroacyclic Schiff base ligand have been reported. The Schiff base ligand is prepared from the condensation reaction of 1, 4-di-(4fluoro-2-aminophenoxy) butane with salicylaldehyde in ethanol. In addition, antibacterial activity of metal ions, Schiff base ligand and their complexes have been investigated. Recent studies show that many Schiff base complexes have antibacterial activity against Grampositive and Gram-negative bacteria. Therefore, we aimed to synthesize new Schiff base complexes and evaluate their antibacterial activity against a number of Gram-positive and Gram-negative bacteria. Methods: Schiff base ligand and their complexes were characterized by mass spectrometry, FTIR, 1 H-NMR and 13 C-NMR spectroscopy. The invitro antibacterial activity of the Schiff base ligand, metal ions and their complexes were evaluated against some Grampositive and Gram-negative bacteria by disk diffusion method and determining minimum inhibitory concentration. Results: In this study, the Schiff base complexes had good antibacterial activity, but the Schiff base ligand and metal ions did not show any antibacterial effect. In some cases, the antibacterial effect of the complexes was higher than that of the standard antibiotics tetracycline and gentamycin. The titanium complex showed the highest antibacterial activity in both methods. This complex created the largest growth inhibition zone (diameter: 100mm) against Staphylococcus aureus, and had the lowest minimum inhibitory concentration against Bacillus subtilis (6.75 mg/mL). Conclusion: The compounds synthesized in our study have strong antibacterial activity.
SYNTHESIS, SPECTROSCOPIC STUDIES AND ANTIBACTERIAL ACTIVITY OF NOVEL SCHIFF BASE METAL COMPLEXES
Mononuclear Copper(II), Nickel(II) and Oxovanadium(IV) complexes of new tetradendate Schiff base ligand derived from the condensation of 5-Bromosalicylaldehyde, 4,5, dichloro o-phenylenediamine with pentane-2,4-dione have been synthesized and characterized by analytical, spectral and electrochemical methods. The complexes were found to have the general formula [M(L)]X (where M = (Cu(II), Ni(II), and VO(IV) X=ClO4-, (SO4) 2-L = mononucleating tetradendate ligand). The invitro antimicrobial activities of the synthesized compounds have been tested against the gram negative and gram positive bacteria. A comparative study of minimum inhibitory concentration (MIC) values of the Schiff base and its complexes indicate that the metal complexes exhibit higher antibacterial activity than the free ligand. © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 1521