Family of Escherichia coli Dr Adhesins: Decay‐Accelerating Factor Receptor Recognition and Invasiveness (original) (raw)

This research investigates the family of Dr adhesins in Escherichia coli, particularly focusing on their role in uropathogenic infections and diarrhea. The study highlights the predilection of certain demographics, such as children and pregnant women, to infections caused by Dr adhesin-expressing E. coli. Notably, the research identifies decay-accelerating factor (DAF) as the key receptor involved in the binding mechanisms of these adhesins, suggesting their contribution to the invasiveness of E. coli and potential links to recurrent urinary tract infections (UTIs). The significance of these findings is underscored by the frequent occurrence of Dr adhesins among pathogenic strains and their variability in virulence, warranting further epidemiological and molecular investigations.