Matrix Metalloproteinases 2 and 9 in Avocation of Multitudinal Complications in Explicitly to Carcinoma: Review (original) (raw)

ABSTRACTMatrix metalloproteinases (MMPs) are a large group of calcium-dependent zinc containing endopeptidases which are mainly concerned with theremodeling of tissue along with degradation of the extracellular matrix. At the present scenario, there is knowledge of about 26 MMPs which are foundto be highly regulated by the growth hormones, cytokines, etc., present within the body. At times of normal homeostasis, their levels within the bodyare low, and their number usually increases at times of pathological conditions. Its generation is known to occur from the pro-inflammatory cells andconnective tissues. They may even lead to the process of apoptosis by its interactions with surface receptors. In the clinical trials sectors, various MMPsalong with their inhibitors are examined to import the properties of being a high biomarker in the cancer diagnosis, antiangiogenic agents, variousother disorders such as chronic allograft nephropathy, diabetic nephropathy, cardiovascular diseases, ...