Dibenzocyclooctadiene Lignans from Schisandra lancifolia and Their Anti-human Immunodeficiency Virus-1 Activities (original) (raw)

2010, CHEMICAL & PHARMACEUTICAL BULLETIN

Previous studies of Schisandra species have reported lignans with various beneficial pharmacological effects such as antihepatitis, antitumor, and anti-human immunodeficiency virus (HIV) activities as typical of this genus. 1-4) Recent researches also showed that some triterpenoids isolated from this genus exhibited anti-HIV activities and inhibitory activities toward cholesterol biosynthesis. 5-9) Schisandra lancifolia, one of species of this genus, is a climbing plant mainly distributed in Mainland of China. 10) In our previous work, some new highly oxygenated nortriterpenoids were isolated from this plant. To search for more new bioactive compounds from this plant, we examined the leaves and stems of S. lancifolia, which led to the isolation of three new dibenzocyclooctadiene lignans, schilancifolignans A-C (1-3), along with thirteen known compounds. In addition, the anti-HIV-1 activities of new compounds 1-3 were evaluated. Described in this paper are their structure elucidation and biological activities.

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact