Intestinal absorption of bile acids in the rabbit: Different transport rates in jejunum and ileum (original) (raw)

Background & Aims: A direct comparison of jejunal and ileal absorption rates of bile acids has not been reported. The aim of this study was to compare the relative transport rates of different bile acids in the jejunum and ileum. Methods: Jejunal and ileal rabbit intestinal segments were perfused with bile acid solutions, and dose-response curves were obtained for taurocholate and other bile acids. The expression and activity of specific transporters were also characterized. Results: Differences in transport rates and mechanisms were identified between the jejunum and ileum, emphasizing the significance of the ileal transport system. Conclusion: Understanding these differences can enhance our knowledge of bile acid reabsorption and potential therapeutic targets for related disorders.