Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection (original) (raw)
Related papers
Intracytoplasmic sperm injection and advanced maternal age: Success or treatment failure?
Pakistan journal of pharmaceutical sciences, 2019
Infertility rate documented in Pakistan is 21.9% with only 25% success rate even after procedures like intracytoplasmic sperm injection (ICSI). This rate is further on the decline with enhancement of female age. We aimed to observe the effect of female age on oocyte parameters and reproductive outcome after ICSI. It was done by retrospective analysis of a quasi- experimental design carried out after approval from "Ethical review board of Islamabad clinic serving infertile couples" from July 2010 to August 2011. The response to ovarian stimulation in (282) females was assessed on the basis of groups, A, B, C and D with age ranges up to 25years; 25.1 to 30years; 30.1 to 35years and >35years, respectively. The outcome was assessed as non-pregnant, preclinical abortion and clinical pregnancy groups on the basis of beta hCG and cardiac activity by trans-vaginal scan. We observed that maximum number of pregnancies 32 (38%) occurred in C group, and least 10 (10%) in group A. T...
Paternal age and outcome of intracytoplasmic sperm injection
Reproductive Biomedicine Online, 2007
In a retrospective study, the outcome of intracytoplasmic sperm injection (ICSI) in two age groups of men was studied. Couples with male partners aged 50 years and over (group A) (n = 227) with mean age of 53 ± 5 years were compared with couples with younger age-group male partners (group B) (n = 227) with a mean age of 38.4 ± 5.8 years. The control group of younger men was selected so that the women's age matched between the two groups. There was no signifi cant difference in pregnancy rate between the two groups (37.9 versus 36.6%; OR = 1.06, 95% CI = 0.72−1.55). There was also no signifi cant difference in the pregnancy rate between men aged 60 years and over as compared with men aged 50 to 59 years (OR = 1.00, 95% CI 0.74−1.37). However, the long-term outcome of these pregnancies needs further investigation. Semen analysis showed signifi cantly lower motility in group A (37.4 ± 20.4) versus group B (46.4 ± 15.5; P < 0.0001). There was a signifi cantly higher fertilization rate in younger men (P < 0.0001; OR = 1.36, 95% CI = 1.19−1.55), but this did not affect the pregnancy rate. In conclusion, it appears that paternal age has no effect on the pregnancy rate after ICSI.
The effect of paternal age on intracytoplasmic sperm injection outcome in unexplained infertility
Arab Journal of Urology
Objective: : To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility Subjects and Methods: : This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining 'unexplained infertility'. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential). Results: : We found that final pregnancy outcomes including clinical pregnancy rate (P = 0.231), live-birth rate (P = 0.143), and miscarriage rates (P = 0.466) were not significantly different between the two age groups. Normal fertilisation (P = 0.01) and cleavage rate after ICSI (P = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (P = 0.041). Conclusions: : Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.
Intracytoplasmic sperm injection outcome of women over 39: an analysis of 668 cycles
Archives of Gynecology and Obstetrics, 2009
Purpose To evaluate intracytoplasmic sperm injection (ICSI) outcome of women over age 39 and to determine when to discourage such couples to undergo IVF using their own oocytes. Methods Four hundred ninety-Wve consecutive women (n = 668 cycles) over age 39 were evaluated by year-byyear age increments to discriminate the independent prognostic factors for the achievement of pregnancy. Results Although the ovarian hyperstimulation performance (COH) and embryological data were not too diverse, the clinical pregnancy rates per embryo transfer decreased from 26 to 13% from age 40 to 44. According to logistic regression, the female age seems to be the only variable in order to predict an ongoing pregnancy. The miscarriage rate increased with advancing female age. It was 33% at age 40 but increased to 100% by age 45. Conclusions The performance of COH and embryological data is not discouraging among women over 39 years in ICSI cycles. However, increased miscarriages as well as decreased implantation rate are mainly responsible for the poor performance of patients with advanced female age. Irrespective of the ovarian reserve testing, ICSI may be refused at age 45 and thereafter.
Impact of paternal age on intracytoplasmic sperm injection cycle results
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2015
Background: The purpose of this study is to compare the impacts of the paternal age of patients included in the intracytoplasmic sperm injection-embryo transfer cycle administered with long protocol. Methods: The patients administered with long agonist protocol, who were primary infertile and had normal over reserves, were divided into two groups based on their sperm concentration. The patients with sperm concentration of over 15 million/ml were defined as group 1, while those with sperm concentration below 15 million/ml were defined as group 2. Results: 602 patients, 302 of whom were in group 1 and 300 of whom were in group 2, enrolled in this study. With regard to treatment results, the implantation rates and clinical pregnancy rates were significantly higher in group 1. In an assessment made to determine if the advanced male age had any impact on the clinical pregnancy rates, it was determined that there was a significant decrease in the clinical pregnancy rates only in group 2. When the patients in group 2 were divided and compared into two patient subgroups, i.e. those below 37 years old and over 37 years old, higher number of mature oocytes, embryos was obtained at a lower dose of recombinant follicular stimulant hormone (r-FSH) in the younger patient subgroup, which significantly increased the clinical pregnancy rates with implementation rates. Conclusions: While the pregnancy and implantation rates significantly decreased by advanced paternal age in oligospermic patients administered with ICSI, the abortus rates increased.
Intracytoplasmic Sperm Injection Cycle Outcomes in Women Aged 40 Years and Over
Gynecology Obstetrics & Reproductive Medicine, 2022
Objective: The main detrimental factor in female fertility is maternal age. Clinical pregnancy and live birth rates decline gradually with age and this decline is dramatical over 40 years. In this study, we examined the in vitro fertilization/intracytoplasmic sperm injection cycle outcomes of women aged 40 years and over. Study Design: This retrospective study included 336 fresh in vitro fertilization/ICSI cycles of women aged ≥40 years. Six groups, stratified by one-year intervals were composed according to age: 40 years; 41 years; 42 years; 43 years; 44 years, and ≥45 years. The primary outcomes were the clinical pregnancy and live birth rates. Results: The clinical pregnancy rate was 18.6% in 40 years old women and it decreased to 4% in women aged ≥45 years. The live birth rates in women aged 40 and 41 years (10% and 6.1% respectively) were higher than the live birth rates in women aged 42 and 43 years (4.3% and 3.8% respectively). There was no live birth in women aged 44 and ove...
Fertility and Sterility, 2010
Objective: To evaluate the effect of male age on clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles, according to sperm concentration. Design: Retrospective, observational study. Setting: Assisted reproduction center. Patient(s): The study included 1,024 couples undergoing ICSI cycles with fresh spermatozoa. Intervention(s): The influence of paternal age on ICSI outcomes of oligozoospermic and normozoospermic patients was evaluated. Main Outcome Measure(s): Rates of high-quality embryos, pregnancy, implantation, and miscarriage were evaluated through linear logistic regression analyses. Result(s): When the sperm concentration was abnormal, paternal age influenced implantation (regression coefficient value ¼ À0.7009) and pregnancy rates (odds ratio ¼ 0.95, 95% confidence interval 0.91-0.99). However, in normozoospermic patients, no influence of paternal age was observed on implantation (regression coefficient value ¼ 0.0566) or pregnancy rates (odds ratio ¼ 1.00, 95% confidence interval 0.97-1.03). Conclusion(s): For couples in which the men are oligozoospermic, the implantation rate could be impaired by increased paternal age. In these couples, the chance of pregnancy decreased 5% for each year of paternal age. When men are normozoospermic, this effect is not observed.
Frontiers in Endocrinology
Background: We conducted a retrospective study on a cohort of couples attending the Department of Andrology and Reproductive Physiopathology at Sandro Pertini Hospital in Rome for Intracytoplasmatic Sperm Injection (ICSI)-assisted reproduction programs. Some of the couples included in the study underwent more than one ICSI cycle. Between January 2015 and April 2017. Objective: To evaluate whether the advancing of the paternal age may have effect on the seminal parameters, thus negatively affecting the embryo formation, development and quality, as well as the pregnancy rate. Materials and Methods: Five hundred and forty three ICSI cycles were performed on 439 couples undergoing Assisted Reproductive Technologies (ART). Patients were subdivided into three male and three female age groups having similar size: Men: ≤38 years (M I), 39-43 years (M II), ≥44 years (M III). Women: ≤35 years (F I), 36-40 years (F II),≥41 years (F III). Discussion and Conclusion: Male age groups did not reveal any statistical significant differences in any age-related semen parameters. We also confirmed a statistical significant increase in the pregnancy rate of couples with older partner age difference and younger female. We found that the advanced male age increases the probability of obtaining one or no type A embryo (N A ≤1), which was almost doubled in the M III group in comparison with M I , suggesting a negative effect of male age on the efficacy of the reproductive outcome in terms of a reduced number of type A embryos. Such an effect does not seem related to semen parameters and may deserve further investigations.
The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age
Human reproduction (Oxford, England), 2017
Does ICSI improve reproductive outcomes compared with conventional IVF when used for non-male factor infertility in women aged 40 years and over? There is no advantage of ICSI over conventional IVF in women aged 40 years and over when used for non-male factor infertility. The use of ICSI has increased dramatically in recent years and is being applied for indications other than male factor infertility. Currently, ICSI is used in 65% of IVF cycles in Europe and in 76% of cycles in the USA. Despite its increase use, there is no clear evidence of a benefit in using ICSI over conventional IVF. Older women undergoing infertility treatments are at an increased risk of having diminished ovarian reserve and lower oocyte quality, which could make ICSI the preferred insemination method in this group. However, studies that have examined the benefits of ICSI in this age group are lacking. A retrospective, single center study included women, aged 40-43 years, who underwent IVF treatments for non-...
Human Reproduction, 1997
In order to examine if the transfer of more than three embryos has any beneficial effect on the outcome of intracytoplasmic sperm injection (ICSI) cycles in women aged > 40 years, a retrospective analysis was made of all the ICSI cycles which were performed in this age group from 1 October 1991 to 31 December 1995. A total of 525 cycles was performed in 321 patients. In 413 cycles, at least one normally fertilized embryo was available for transfer. In 271 cycles, one to three embryos were replaced while in the remaining 142 cycles at least four embryos were replaced. There was no difference in implantation rate (number of gestational sacs/number of embryos transferred), after the transfer of one to three embryos (5.2%), compared with the transfer of at least four embryos (5.1%). The pregnancy rate/embryo transfer and the clinical pregnancy rate/embryo transfer were, however, higher when at least four embryos were replaced than was the case with one to three embryos (27.5 versus 11.8%, P < 0.0001 and 20.42 versus 9.96%, P < 0.005, respectively). There were no statistically significant differences in the delivery rates, multiple pregnancy rates or spontaneous abortion rates. The pregnancy rate and the clinical pregnancy rate after ICSI in women > or = 40 years of age are related to the number of embryos replaced.