An essential role of Pak1 phosphorylation of SHARP in Notch signaling (original) (raw)

This study identifies the critical role of Pak1-mediated phosphorylation of SHARP in the regulation of Notch signaling. Notch signaling is pivotal in various cellular processes such as fate determination, proliferation, and apoptosis. The research demonstrates that Pak1 enhances the repressor function of SHARP on Notch target genes and that phosphorylation of specific sites within SHARP is essential for this modulation. By utilizing a series of molecular assays, the authors illustrate how Pak1 facilitates the interaction between SHARP and RBP-Jk, thereby influencing Notch-mediated gene expression.