Magnesium Sulphate Treated Severely Asphyxiated Neonates, Their Characteristic and Outcome (original) (raw)

Asian Journal of Pediatric Research

Introduction: Perinatal asphyxia is a common neonatal problem and contributes significantly to neonatal morbidity and mortality. Encephalopathy occurs in 50% to 60% of patients with severe perinatal asphyxia. Moderate hypoxic ischaemic encephalopathy (HIE), 10% to 20% die and 30% to 40% develop neurodeficits, whereas 50% of those with severe HIE die and almost all survivors develop neurodeficits. The systematic administration of magnesium sulphate (MgSO4) after perinatal asphyxia has shown effective resolution of neuronal injury. We have conducted this study to validate the effect of MgSO4 in severely asphyxiated neonates, so as to utilize its benefits on ameliorating the outcome associated with severe perinatal asphyxia/HIE. Objective of the Study: To determine the characteristics and outcome of magnesium sulphate on neurological outcome in severe perinatal asphyxia Materials and Methods: A prospective interventional study of magnesium sulphate treatment of neonates with severe pe...

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