Serine proteases and their serpin inhibitors in Alzheimer's disease (original) (raw)

Interest in proteases and their inhibitors in the pathogenesis of Alzheimer's Disease (AD) has expanded recently. Proteases participate in numerous processes key to growth and development in the nervous system, and recent findings suggest an imbalance in these proteases and their inhibitors may contribute to the development of AD, particularly in relation to amyloid beta protein. This paper discusses various serine proteases and their serpin inhibitors, investigating their roles and interactions in the progression of Alzheimer's disease.