Straightforward entry to the pipecolic acid nucleus. Enantioselective synthesis of baikiain (original) (raw)

The enantioselective synthesis of baikiain, a natural product derived from pipecolic acid, is reported. Employing a novel strategy that involves regio- and stereoselective epoxide ring-opening followed by ring-closing metathesis and oxidation, the synthesis is accomplished in five steps with high overall yields and enantiomeric purity of up to 99%. This method provides a straightforward approach to accessing baikiain and pipecolic acid derivatives, paving the way for further applications in the synthesis of various heterocyclic compounds.