A novel procedure for dissociating the anatomical bases of the behavioral effects of amphetamine (original) (raw)

1987, Pharmacology Biochemistry and Behavior

TOWELL, A , P WILLNER AND R MUSCAT A novel procedure for dtssoctatmg the anatomtcal bases of the behaworal effects of arnphetamtne PHARMACOL BIOCHEM BEHAV 28(3)423-426, 1987 --A novel operative procedure is described in which the same cannula may be used to administer drugs e~ther to the caudate nucleus (CN) or to the nucleus accumbens (NAcc) of the rat M~croinject~ons of amphetamine (10 or 20/xg) into the CN produced a reliable and robust stereotyped response, when admlmstered to the NAcc of the same ammai the higher dose increased locomotor activity The stereotypy following peripheral administration of amphetamine (5 mg/kg) was antagonlsed by Infusions of halopendol (30/~g) into the CN but not into the NAcc Conversely, the locomotor activity following a lower dose of amphetamine (1 mg/kg) was antagomsed by tnfuslons of halopendol (5 gg) ~nto the NAcc but not into the CN The results confirm earlier reports that d~fferent anatomical structures mediate the behavioral effects of low and high doses of amphetamine Amphetamine Haloperldol Locomotor act~wty Stereotyped behavior Dopamme Caudate nucleus Nucleus accumbens Rat

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