Γ-Diketone Central Neuropathy: Quantitative Morphometric Analysis of Axons in Rat Spinal Cord White Matter Regions and Nerve Roots (original) (raw)

Toxicology and Applied Pharmacology, 2003

Abstract

A quantitative analytical method was used to measure myelinated axon morphometric parameters (e.g., axon area, ratio of axon area/fiber area, and index of circularity) in rat nervous tissue during intoxication with 2,5-hexanedione (HD). Parameters were assessed in nerve roots (dorsal and ventral) and in ascending (gracile fasciculus and spinocerebellar tract) and descending (corticospinal and rubrospinal tracts) spinal cord white matter

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