The Burden of Influenza-Associated Hospitalizations in Oman, January 2008-June 2013 (original) (raw)

Influenza Hospitalization Epidemiology from a Severe Acute Respiratory Infection Surveillance System in Jordan, January 2008-February 2014

Influenza and other respiratory viruses, 2015

Acute respiratory infections (ARIs) are a major cause of morbidity and mortality worldwide. Influenza typically contributes substantially to the burden of ARI, but only limited data are available on influenza activity and seasonality in Jordan. Syndromic case definitions were used to identify individuals with severe acute respiratory infections (SARI) admitted to four sentinel hospitals in Jordan. Demographic and clinical data were collected. Nasopharyngeal and oropharyngeal swabs were tested for influenza using real-time reverse transcription polymerase chain reaction and typed as influenza A or B, with influenza A further subtyped. From January 2008-February 2014, 2,891 SARI cases were tested for influenza, and 257 (9%) were positive. While 73% of all SARI cases were under five years old, only 57% of influenza-positive cases were under five years old. Eight (3%) influenza-positive cases died. An annual seasonal pattern of influenza activity was observed. The proportion of influenz...

Detection of Influenza Viruses Among Hospitalized Cases Suffering from Severe Acute Respiratory Illness (Sari) in Sana’A City, Yemen

Universal Journal of Pharmaceutical Research

Influenza is a major cause of morbidity and mortality around the world. So national influenza surveillance have been important for understanding the epidemiology of influenza over time. The aims of this study were to determine the prevalence rate of influenza viruses among hospitalized patients with severe acute respiratory illness (SARI), identify circulating types and subtypes of influenza viruses among them, and determine the risk factors associated with SARI. A total of 320 hospitalized patients suffering from SARI at Al Joumhouri University hospital in Sana’a city were enrolled; and their age was ranged from < 1 year to ≥ 56 years. Both nasopharyngeal and oro-pharyngeal swabs were collected from each patient and tested by using rRT-PCR technique for the detection of influenza A, influenza B and subtypes of influenza A viruses (A/H1N1(2009) and A/H3N2). The crude prevalent rate of influenza viruses among SARI patients was 10.9%;the female rate was 12.4%, and the male rate was...

Influenza circulating viruses, positivity rate and risk factors for influenza associated severe acute respiratory infection during 2018/2019 winter season, Yemen

BMC Infectious Diseases, 2022

Background The burden of seasonal influenza in conflict counties is exacerbated due to limited resource and collapse of health system. During 2018 /2019 season, two-fold increase in the incidence of influenza was reported in Yemen with 22% case fatality of severe acute respiratory infection (SARI). The aims are to analyze the influenza circulating viruses, positivity rate and risk factors for hospitalizing influenza associated-SARI. Methodology We used a retrospective analytical study based on surveillance data. All reported patients during 2018/2019 season, fulfilling the WHO cases definition for SARI or influenza like illness (ILI), and had laboratory result from the National Laboratory were included. Influenza positivity rate was calculated, all SARI and ILI patients with positive influenza were included for further analysis by univariate and multivariate binary logistic regression. Crude and adjusted Odds ratio (AOR), 95% confidence interval and P-value < 0.05 were used for s...

Severe Acute Respiratory Infections With Influenza and Noninfluenza Respiratory Viruses: Yemen, 2011-2016

INQUIRY: The Journal of Health Care Organization, Provision, and Financing, 2019

In 2010, Yemen started the surveillance for severe acute respiratory infections (SARIs) by establishing 2 sentinel sites in Sana’a and Aden city. This study aims to determine the proportions of influenza and noninfluenza viruses among SARI patients and to determine the severity of SARI and its associated factors. The data of SARI patients who were admitted to SARI surveillance sites at Al Johory hospital in Sana’a and Al Wahdah hospital in Aden city during the period 2011-2016 were analyzed. The proportions of positive influenza viruses (type A, B) and noninfluenza viruses (respiratory syncytial, adenovirus, human parainfluenza, and human metapneumovirus), intensive care unit (ICU) admission rate, and fatality rate among SARI patients were calculated. A total of 1811 of SARI patients were admitted during 2011-2016. Of those, 78% were <15 years old. A total of 89 (5%) patients had influenza viruses and 655 (36%) had noninfluenza viruses. The overall ICU admission rate was 40% and ...

Clinical Presentation and Outcome in Hospitalized Patients of 2009 Pandemic Influenza A (H1N1) viral infection in Oman

Objectives: In 2009, cases of human infection with a novel influenza A (H1N1) virus were detected and soon reached a pandemic level. Presenting clinical features of this disease in Oman were observed and an attempt was made to identify features predicting the high risk of mortality. Methods: The clinical and laboratory features at the time of presentation in adult patients admitted with flu-like illness or pneumonia were studied who were later diagnosed as H1N1 infection by PCR of nasopharyngeal and/or throat swabs. Results: H1N1 infection mostly affected younger individuals who presented with fever and cough. One-third of the patients had rhinorrhea and a few had vomiting and diarrhea. Chest crepitations were common. Most of the patients had normal or low cell counts. The chest X-ray was normal in 23 (41.8%) cases, while in other cases pneumonia was detected characteristically starting from base and extending up. Almost half of the patients were either in frank or impending respiratory failure. Nine (16.4%) patients died. Conclusion: It is difficult to identify H1N1 influenza cases from other patients with a flu-like illness, but it can be strongly suspected when a patient presents with basal pneumonia, particularly if bilateral, with lymphocytopenia, and is hypoxemic, in the presence of other H1N1 infected cases in the community. These features are also indicative of severe illness with high mortality risk.

Epidemiology of severe cases of influenza and other acute respiratory infections in the Eastern Mediterranean Region, July 2016 to June 2018

Journal of Infection and Public Health, 2019

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Characteristics of severe acute respiratory infection-associated hospitalization in Yemen, 2014/15

Eastern Mediterranean Health Journal, 2016

Yémen : caractéristiques des cas d'hospitalisation associés aux infections respiratoires aiguës sévères, 2014-2015 RÉSUMÉ Cette étude présente les agents étiologiques, les données démographiques des patients, la saisonnalité et les pathologies sous-jacentes chez des patients hospitalisés en raison d'infections respiratoires aiguës sévères (IRAS) au Yémen. Nous avons réalisé une analyse descriptive rétrospective des données portant sur les IRAS et couvrant la période de janvier 2014 à décembre 2015. Des sécrétions rhinopharyngées ont été prélevées par écouvillonnage pour chaque patient afin d'être testées en laboratoire. Un total de 1 346 échantillons diagnostiques ont été testés, parmi lesquels 733 (54 %) se sont avérés positifs aux virus de la grippe. Les virus de la grippe A(H3N2) (5 %) et A(H1N1)pdm09 (3 %) étaient prédominants. Le virus respiratoire syncytial (VRS) a été observé principalement chez les enfants (41 %). Les sujets de sexe masculin étaient plus touchés (61 %) que les sujets de sexe féminin. L'âge médian était d'un an (intervalle : 0,5-94). La durée médiane d'hospitalisation était de 6 jours. Les maladies cardio-vasculaires chroniques constituaient la pathologie la plus fréquemment rapportée ; 67 % ne présentaient aucune pathologie sous-jacente établie. Les cas d'hospitalisation étaient généralement associés à des virus respiratoires, en particulier au VRS, à l'adénovirus et à la grippe. ABSTRACT This study aims to describe etiological agents, demographic details of patients, seasonality and underlying conditions among patients hospitalized due to viral severe acute respiratory infection (SARI) in Yemen. We carried out a retrospective descriptive analysis of data from January 2014 to December 2015. Nasopharyngeal swabs were taken from each patient for laboratory testing. A total of 1346 diagnostic specimens were tested, of which 733 (54%) were positive for influenza viruses. Influenza A(H3) and A(H1N1) pdm09 predominated. Respiratory syncytial virus (RSV) was reported predominantly among children (41%). Males (61%) were more affected than females. The median age was 1 year (range 0.5-94.0). The median length of hospitalization was 6 days. Chronic cardiovascular disease was the most commonly reported underlying condition, but 67% had no documented underlying disease. Respiratory viruses, particularly RSV, adenovirus and influenza, were commonly associated with hospitalization for SARI.

Influenza-associated Severe Acute Respiratory Infections in Two Sentinel Sites in Lebanon - September 2015 to August 2016

Influenza and other respiratory viruses, 2017

Given the sparse information on burden of influenza in Lebanon, the Ministry of Public Health established a sentinel surveillance for Severe Acute Respiratory Infections (SARI) to identify the attribution of influenza to reported cases. We aim to highlight the proportion of influenza-associated SARI from September 1st 2015 to August 31st 2016 in two Lebanese hospitals. The study was conducted in two sentinel sites located in Beirut suburbs and Southern province of Lebanon. WHO's 2011 standardized SARI case definition was used. Data from 1 September 2015 to 31 August 2016 was reviewed and all-cause hospital admissions numbers were obtained. Nasopharyngeal swabs were collected and tested by RT-PCR. Descriptive and bivariate analyses were conducted using STATA 13. The two sentinel sites reported 746 SARI cases during the studied time frame; 467 from the Southern province site and 279 from the Beirut suburbs site. SARI reports peaked between January and March 2016. All, except four,...

Epidemiology of Influenza in Patients with Acute Lower Respiratory Tract Infection in South of Iran (2015-2016)

Acta Facultatis Medicae Naissensis

Summary Influenza is of particular importance because of the pace of epidemics, the extent and number of infected people, and the severity of the side effects. The aim of this study was to investigate the epidemiological and clinical aspects of this disease during the last epidemic in southern Iran. The present cross-sectional study was performed on the basis of secondary data analysis and information in medical records of patients with acute lower respiratory system infection in hospitals affiliated to Jahrom University of Medical Sciences. Data were analyzed by SPSS 18 using descriptive statistics, Chi-square test and logistic regression at 0.05 significance level. From 1st September 2015 to 20th March 2016, 108 patients with acute lower respiratory tract infection with a mean age of 42.92 ± 19.65 years were admitted to Jahrom hospitals, of which 43 were diagnosed with definite influenza, all of which (100%) had H1N1 type A influenza. There were eight deaths in all, of which five ...

Comparison of common acute respiratory infection case definitions for identification of hospitalized influenza cases at a population-based surveillance site in Egypt

PLoS ONE, 2021

Background Multiple case definitions are used to identify hospitalized patients with community-acquired acute respiratory infections (ARI). We evaluated several commonly used hospitalized ARI case definitions to identify influenza cases. Methods The study included all patients from a population-based surveillance site in Damanhour, Egypt hospitalized for a broad set of criteria consistent with community acquired ARIs. Naso- and oropharyngeal (NP/OP) swabs were tested for influenza using RT-PCR. Sensitivity, specificity and PPV for influenza identification was compared between the 2014 WHO Severe Acute Respiratory Infection (SARI) definition (fever ≥38°C and cough with onset within 10 days), the 2011 WHO SARI definition (fever ≥38°C and cough with onset within 7 days), the 2006 PAHO SARI definition, the International Emerging Infections Program (IEIP) pneumonia case definition, and the International Management of Childhood Illness (IMCI) case definitions for moderate and severe pneum...