An Increase in Basal Cell Carcinoma among the Young: an Epidemiological Study in a Middle-South Italian Population (original) (raw)
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A Clinical Study of Basal Cell Carcinoma
Medical Archives
Introduction: Basal cell carcinoma (BCC) is a non-melanocytic skin malignancy arising from basal cells of epidermis or follicular structures. Etiology of BCC is a multifactorial combination of genotype, phenotype, and environmental factors. There are several clinical variants of BCC including nodular, cystic, superficial, morphoeic, keratotic, pigmented and micronodular. Aim: The aim of our study was to analyze the recent clinical trends of basal cell carcinoma by reviewing a single institution's experience. Methods: Total number of 422 patients clinically diagnosed with basal cell carcinoma were included in the study. Data on age, gender, skin type, personal and family history, duration of disease, localization of lesions, clinical type of lesions, and recurrence rate were collected and analyzed. The data were statistically evaluated. Results: More than 80% of all BCC's were located on sun-exposed skin areas (p<0.05).The male /female ratio was 1:0.92. The nodular BCC was the most frequent type (59.2%), followed by the superficial (16.1%), pigmented (15.2%) and morphoeic (9.5%) types. The nodular and pigmented types were predominant located on the head and neck, whereas the trunk was the most common location for the superficial type (p<0.05). The tumor is commonly found in concomitance with skin lesion related to chronic sun exposure, such as actinic keratoses, solar lentigines and facial telangiectasia. During this study period, 41 cases showed recurrence of the cancer as the overall recurrence rate was 9.7%. There were no cases with metastasis or fatal outcome. Conclusions: The factors related to the development of BCC were older age and exposure to ultraviolet rays both in recreational and in occupational form. The prevention of BCC is based on the knowledge of risk factors, early diagnosis and treatment, particularly in susceptible populations.
A local perspective on basal cell carcinoma : frequency of subsequent skin tumours
2017
Malta Medical School Gazette Volume 01 Issue 04 2017 Abstract Background: Basal cell carcinoma (BCC) is the commonest skin malignancy with a significant risk of recurrence and new primaries. The major risk factor is ultraviolet (UV) radiation, which is relevant to Malta, where the UV index is frequently high. Objective: The aim of this study was to follow up patients diagnosed with BCC, analyse the occurrence of subsequent malignant and pre-malignant skin tumours and assess whether variables like age and gender modify risk. This will aid local screening methods and follow-up protocols. Method: Patients registered with BCC in the Malta National Cancer Registry in 2007 were included in our study. Histology results belonging to these patients were followed up until the end of 2014. Risk of developing further lesions when accounting for age and gender was calculated using the Chi^2 test for Independence and hazard ratios. Results: A total of 382 patients were diagnosed with BCC in 2007....
Dermatopathology
Background and Objectives: Basal carcinoma of the skin (BCC) is part of the nonmelanoma skin cancer (NMSC) family and is the most frequently occurring type of skin cancer in humans. A combination of clinical and histopathological approaches is necessary in order to establish the best treatment regime for patients who have been diagnosed with this type of cancer. The objective of the present study was to establish the statistical value of prediction for certain sociodemographic characteristics (age category and environment of origin) and histopathological parameters of the subjects that could be related to the incidence of diagnosis with certain histopathological subtypes of BCC. Materials and Methods: In order to verify the veracity of the established research hypotheses, we conducted a retrospective study based on the histopathological reports of 216 patients who were treated at the Pathology Department of Mureș Clinical County Hospital. Results: Cystic BCC is higher in patients wh...
Basal cell carcinoma: an updated epidemiological and therapeutically profile of an urban population
Acta Cirurgica Brasileira, 2006
Purpose: To describe the epidemiological profile of basal cell carcinoma patients at a private hospital in São Paulo and to evaluate the treatment adopted. Methods:A prospective study of 202 patients, on which 253 lesions were diagnosed for histopathological exam as basal cell carcinoma within the period of January 2001 to September 2003, in the Plastic Surgery Residency Program at the Hospital Jaraguá. The susceptibility factor of the host, the environment variables, the characteristics of the lesions and the efficacy of the treatment were examined. The data were statistically evaluated. Results:The incidence of basal cell carcinoma was 126 cases per 100,000 patients in a period of 32 months (36 cases per 100,000 patients/year). The patients were evenly distributed in terms of sex: 48% male and 52% female. The greater incidence was in patients between the ages of 60 and 80 years and the average was 64 years. The survey revealed susceptibility factors such as white race and phototypes I and II in 95.5% of the patients. Exposition to ultraviolet radiation was reported by 77% of the patients and the most frequent location of tumors was on the face (71.2% of the cases). Actinic keratosis and a history of skin cancer were reported in 43.6% and in 25% of the cases, respectively. The adopted treatment was surgery in 99.4% of the cases and only one patient was treated with radiotherapy. Twenty lesions (8%) had incomplete excision.The recurrence rate was 2% (5 cases). There were no cases with metastasis or fatal outcome. Conclusions: The factors related to the development of basal cell cancer which were significantly present in the population surveyed were: older age, white individuals, phototypes I and II, presence of actinic keratosis, previous history of non-melanoma skin cancer and exposure to ultra-violet rays both in recreational and in occupational form.The surgical treatment employed was effective with a rate of incomplete excision and recurrence similar to those found in the literature. RESUMO Objetivo:Traçar o perfil epidemiológico dos portadores de carcinoma basocelular e , avaliar o tratamento instituído no Serviço de Residência de Cirurgia Plástica do Hospital Jaraguá. Métodos: Foi realizado um estudo prospectivo de 202 pacientes, nos quais foram diagnosticados 253 lesões por exame anátomo-patológico como carcinoma basocelular no período de janeiro de 2001 a setembro de 2003, no Serviço de Residência de Cirurgia Plástica do Hospital Jaraguá. Foram abordados fatores de susceptibilidade do hospedeiro, fatores ambientais, características das lesões, o tratamento instituído e sua eficácia.
Basal cell carcinomas - clinical-evolutional and histopahotologic aspects
Current health sciences journal, 2009
Basal cell carcinoma (BCC) is the most frequent cutaneous tumour. Having as aim the identification of the clinical-evolutional and histopathologic aspects of the basal cell carcinomas, we have undertaken a retrospective study for a period of 5 years, from 1st January 2004 to 31st December 2008, on 706 patients interned in the Dermatology Clinic of Craiova, whom indicated 738 tumours. A clinical data was drawn for the patients, containing the identification data, environment, profession, cancer localisation and history of the disease, clinical and histopathologic diagnosis. Results. In our lot, the most numerous cases were of pearly BCC (33.6%), nodular BCC (22.2%), respectively scar plane BCC (13.1%).Regarding the histopathologic type, the repartition was as it follows: solid BCC (33.7%), polymorph (19.2%), adenoid (13.1%), keratinised (11.8%), superficial (7.0%), cystic (3.8%), pigmented (3.8%), scleroderma form (2.2%), in situ (1.4%).
Epidemiological study of basal cell carcinoma in a community hospital
Th e term non-melanoma skin cancer (NMSC) is commonly used with reference to basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC is the most frequent malignant neoplasm in the Caucasian population and accounts for 80-85 percent of all skin cancers. Risk factors for the development of this pathology include those related to the host, and those related to environmental factors. In the last few decades, BCC, more than SCC, has undergone a sustained increase of incidence, 1,2 including young populations. 3 Among other factors, this is due to changes in the sun exposure habits of certain population groups, and to depletion of the atmospheric ozone level. Since BCC incidence increases with age, greater life expectancy, along with a majority of elderly people in the population, are yet other factors involved in the growing number of cases, which shall continue to increase in the next few decades. In spite of this worldwide increase in cases, true incidence of BCC is diffi cult to establish, because no exact regional and glo-Abstract Introduction. Even though basal cell carcinoma (BCC) is the most frequent human neoplasm, there are no precise statistics on this entity. In order to learn about the epidemiologic characteristics of our population we conducted a prospective, descriptive and transversal study. Objective. To determine clinical, histopathological and demographic characteristics, and known risk factors of BCC in our population. Materials and methods. Complete clinical history and histopathologic confi rmation were performed for all patients with BCC that consulted the Hospital Aleman Dermatology Department between June 2007 and May 2008. Results. The sample size consisted of 125 patients and 222 lesions. Sixty eight percent had only one lesion. The ages ranged from 32 to 103 years of age, with an average of 66 years. Forty one percent were females and 59 percent were males, with a male:female ratio 1.4:1. Ninety three percent of patients had phototypes II and III, with intense recreational sun exposure and severe photodamage. Thirty four percent had personal history of skin cancer. The distribution of lesions was as follows: 46 percent in head and neck, 27 percent in trunk, and 17 percent in limbs. The superfi cial form was the most frequent clinical type seen in trunk and limbs. The infi ltrative growth histopathological variant prevailed in head, neck and limbs (41 percent), and the superfi cial variant prevailed in trunk (54 percent). Conclusion. In the studied population, the more aff ected age range was 60 to 69 years, with higher prevalence in male patients, except for those younger than 40 years. A high percentage of patients had a personal history of skin cancer, and showed multiple simultaneous lesions. Most patients were of phototypes II and III, with a high degree of photodamage and of intense intermittent sun exposure (73 percent). Nevertheless, only 20 percent used sun exposure protection measures. Unlike what has been published, we found a lower percentage of head and neck involvement (46 percent), and a higher number of aggressive clinical and histopathological forms. Finally, we stressed the importance of carrying out epidemiological studies as the one hereby presented, which provide relevant data about our population, taking into account that no prospective studies have been recently published (Dermatol Argent 2009; 15(1):37-43).
Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti, 2012
Basal cell carcinoma (BCC) recurrences are relatively frequent event in a routine dermatologic practice. One of the most important factor which impacts risk of their development is a histomorphological appearance of tumor. The purpose of our study was to compare histological types of primary and corresponding relapsing BCCs of the skin. The study included 36 cases of BCC recurrences from 34 patients, 17 women and 17 men. The patients ranged in age from 32 to 97 years, with a mean age of 67.1 years at the time of (the first) recurrence. Both tumor groups generally exhibited the same proportion of indolent and aggressive histological phenotype. In 21 cases (58.4%), we found an identical histological BCC type in primary and subsequent relapsing lesion. In 3 cases (8.3%), primary lesion showed indolent histological features without aggressive--growth component, while recurrent tumor already manifested it. Conversely, in next 3 cases (8.3%) primary tumor exhibited focal infiltrative-grow...
Age and Site Prevalence Oe Histologic Subtypes Oe Basal Cell Carcinomas
International journal of …, 1995
Background. Basal cell carcinomas (BCC) are the most frequently diagnosed skin cancers. The relationships between some clinical parameters, such as sex, age, and location of the tumor, and the histologic patterns play an important role as factors predictive of recurrence and treatment implications. Methods. A total of 693 patients with BCC, divided according to sex, age, and location of the tumor were studied. The histologic patterns considered were nodular, superficial, and morpheiform BCC and fibroepithelioma. The correlation between clinical and histologic parameters was analyzed. Results. All histologic patterns considered were most commonly represented in the 7th and 8th decades. There were no sex differences. A prevalence of a superficial pattern for sununexposed areas and of a nodular pattern for sun-exposed areas was observed. The morpheiform pattern showed no correlation with any body site. The fibroepithelioma showed an absolute prevalence for the lumbosacral region.
in a Population Younger Than 40 Years Incidence of Basal Cell and Squamous Cell Carcinomas
2009
Context The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives To estimate the sex-and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample. Design Population-based retrospective incidence case review. Setting Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project. Participants Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003. Main Outcome Measures Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time. Results During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the ageadjusted incidence of basal cell carcinoma per 100 000 persons was 25.9 (95% confidence interval [CI], 22.6-29.2) for women and 20.9 (95% CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (PϽ.001) but not men (P=.19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0% of tumors were solely nodular basal cell carcinoma and 11.0% had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age-and sex-adjusted incidence per 100 000 persons of 3.9 (95% CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P=.01) and men (P=.04). Conclusions This population-based study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.
Journal of Babol University of Medical Sciences, 2023
Background and Objective: Basal cell carcinoma is the most common human malignancy that has been increasing in recent years. The aim of this study is to determine the demographic and histopathological pattern of this malignancy in the pathology departments of state hospitals in Babol from 2013 to 2020. Methods: In this retrospective study, after reviewing the existing files with the final diagnosis of basal cell carcinoma from 2013 to 2020, the patients' information including age, gender, lesion location and microscopic subgroup were recorded and analyzed. Findings: In this study, 367 cases were obtained from Shahid Beheshti and Shahid Yahyanejad Hospitals in Babol with the diagnosis of basal cell carcinoma. The mean age of people in both genders was 67±10.89 years. 69% of the samples were men and 31% were women (p<0.001). The highest frequency was from the scalp area (134 samples) and the lowest frequency was related to the chest (3 samples). The most common histopathology subtype was nodular type and the rarest types were metatypical and clear cell carcinoma. A statistically significant relationship was observed between the location of the sample and gender (p=0.023); the cheek in men and the nose in women were more common than the other gender. The highest incidence was seen in 2017 with 83 cases, which was a significant increase compared to the previous year. Conclusion: Based on the results of this study, the high incidence of basal cell carcinoma in the head and face area of elderly people, especially men, reveals the need to inform high-risk communities and to be more familiar with therapists, especially dentists who are in close eye contact with the face.