Clinical, Metabolic and Hormonal Profiles of Bangladeshi Adolescents with Polycystic Ovary Syndrome. European Endocrinology (original) (raw)
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Clinical, Metabolic and Hormonal Profiles of Bangladeshi Adolescents with Polycystic Ovary Syndrome
European Endocrinology, 2021
Aalpona and Shahjada Selim have no financial or non-financial relationships or activities to declare in relation to this article. Review Process: Double-blind peer review. Compliance with Ethics: All procedures were followed in accordance with the responsible committee on human experimentation and with the Helsinki Declaration of 1975 and subsequent revisions, and informed consent was received from the patients involved in this study.
Correlation of Clinical Characteristics and Selective Biochemical Marker in Adolescent PCOS
Background: It is fundamental to comprehend the incidence of polycystic ovarian syndrome (PCOS) worldwide because geographic and ethnic variations might significantly affect the clinical state. This study aims to measure the correlation between clinical characteristics and specific biochemical markers in adolescents with PCOS. Methods: A cross-sectional study was conducted in the Department of Obstetrics & Gynaecology, Institute of Child and Mother Health, Matuail, Dhaka, from January 2015 to December 2015. Ninety-five suspected cases of adolescent PCOS patients were selected using purposive sampling. Results: More than one-third (35.8%) of the patients belonged to the age group of 17-18 years; most of them were unmarried (92.6%) with normal BMI (52.6%). Among them, 70.5% had oligomenorrhoea, and 40% had hirsutism; the mean value of FSH, LH, and testosterone was 4.04±1.42, 9.92±5.57 (IU/liter), and 1.92±0.48 (nmol/L) respectively. About 65% of adolescents had normal fasting glucose/insulin ratio, but insulin resistance was found in 35% of the participants. Serum FSH was not significant (p=0.756) among the categories of menstrual abnormality, but serum LH (P=0.010) and LH/FSH ratios (P=0.014) had significant association among the patients with amenorrhoea and oligomenorrhoea. FSH 0.756, LH 0.010* LH/FSH 0.014* Conclusion: The study found that adolescents' serum LH and LH/FSH ratios were significantly higher with amenorrhoea and oligomenorrhoea. Among the participants, no statistically significant difference was noted in fasting insulin levels. However, the fasting glucose/insulin ratio was higher in individuals with neuropathic hemorrhagic compared to those with amenorrhea and oligomenorrhea.
Indian Journal of Obstetrics and Gynecology Research
One of the most prevalent metabolic disorders among women of reproductive age is polycystic ovarian syndrome (PCOS).Menstrual dysfunction and androgen excess symptoms, such as hirsutism and acne, are common in women with PCOS. Additionally, there may be an increased risk of other morbidities such as obesity, insulin resistance, type 2 diabetes mellitus, cardiovascular diseases, infertility, cancer, and psychological disorders.This study is an attempt to summarise the prevalence of polycystic ovarian syndrome(PCOS) in adolescent girls and young women residing in the National Capital Region belonging to the age group of 11-30 years.The study was questionnaire-based and carried out for a duration of 6 months with 267 participants. The BMI of the participants was calculated using the formula: BMI= weight in kgs/ height in m2. PCOS was diagnosed using a questionnaire with Rotterdam’s criteria.The prevalence of PCOS was found to be 77.1%. The mean age group at which maximum number of part...
The incidence of metabolic syndrome in adolescents with different phenotypes of PCOS
Ginekologia Polska
Objectives: To evaluate the incidence of metabolic syndrome in Turkish adolescents with different phenotypes of polycystic ovary syndrome (PCOS). Material and methods: This cross-sectional study was performed on the Youth Center clinic of a tertiary referral hospital in Turkey. Adolescents with PCOS (n = 144) were classified into four phenotype groups according to the presence of oligo/anovulation (O), hyperandrogenism (H), and polycystic ovarian morphology (P) as follows: Phenotype A (O + H + P), Phenotype B (H + O), Phenotype C (H + P), Phenotype D (O + P). The adolescents gave early follicular phase blood samples for endocrine and metabolic tests. The incidence and the presence of parameters of metabolic syndrome were assessed among the four groups. Results: In total, 54.9% of the adolescents with PCOS were overweight and 25.7% had metabolic syndrome. The incidence of metabolic syndrome in Phenotypes AD were as follows: 39.5%, 20.5%, 26.5%, and 15.2%, respectively. Although body mass index was higher in the Phenotype A group, insulin resistance was similar in all of the phenotype groups. The most common dyslipidemia was low HDL-C levels and this was present in more than half of the adolescents with PCOS. Both body mass index and total testosterone levels were significantly higher in adolescents with metabolic syndrome in comparison to those without metabolic syndrome. Conclusions: Although low HDL-C levels and insulin resistance are common PCOS findings in adolescents, the metabolic profile seems to be worse in Phenotype A than the other phenotypes. Therefore, screening programs should evaluate patients based on the known risk factors and phenotypes for adolescents with PCOS.
Journal of Reproduction & Infertility
Background: PCOS is a common endocrine disorder of reproductive age with high morbidity that its prevalence ranging from 5.6% to 26%. The aim of this study was to evaluate the prevalence of PCOS in Iranian adolescent girls aged 14-19 years based on adults and adolescents’ criteria. Methods: This cross-sectional study was carried out with 650 high school adolescent girls in Mashhad city, north-east of Iran. PCOS was defined as the presence of three or two of the three features including oligo/amenorrhea, clinical or biochemical hyperandrogenism, and polycystic ovaries. Descriptive statistics, chi-square, and t-test were used to analyze the data through SPSS vs 22 (SPSS Inc., USA) and the significance level was set at p≤0.05. Results: The mean age of adolescent girls was 16.73±3.4 years. The prevalence of PCOS using Rotterdam, National Institutes of Health (NIH), Androgen Excess– PCOS Society (AES), European Society of Human Reproduction and Embryology (ESHRE)/American Society for Rep...
Exploring the Prevalence of PCOS: Addressing Challenges and Impact on Adolescent
International Journal of Science and Research (IJSR), 2024
Polycystic ovarian syndrome-A multifactorial reproductive, metabolic and hormonal disorder affecting an increasing number of Adolescent girls and women in reproductive-age. It's first observed by 'stein-Leventhal' so known as 'stein-Leventhal syndrome. commonly caused by multiple factors like irregular periods which further may leads to infertility and complications during pregnancy. Excess male hormone Androgen, in severe cases leads to hirsutism. Along with some metabolic complications like insulin resistance 7 % leads to diabetes type 2. all above issues impacts the quality of Social and Psychological Wellbeing, increase biopsychosocial influence and social gauche. The main cause is modified lifestyle and genetics. This study delves into the intricate landscape of PCOS and its prevalence among adolescent girls in Yavatmal city of Maharashtra (India). Through a comprehensive review of existing literature, community surveys, This study aims to elucidate the burgeoning ratio, phenotypic variations, and sociodemographic factors influencing PCOS.
IP innovative publication pvt. ltd, 2019
Polycystic ovary syndrome is a common female endocrine disorder, complex for managing clinicians and a scientific challenge for researchers. It is a multifaceted disease arising from hereditary, non-hereditary intra and extra uterine environmental influences. The exact pathophysiology of PCOS is complex and remains unclear. The objective of this study is to find the prevalence of PCOS and also the risk factors associated with it among women aged 17-24 years of age so as to identify young women at a risk of developing PCOS. This cross -sectional study was conducted in a medical college in Nerul, Navi Mumbai situated in Maharashtra among 456 medical, dental, physiotherapy students in the age group of 17-24 years. A prevalence rate of 21.05 % was identified. Among those with PCOS, the mean age was 21.18 years. 22.22% of the subjects were at high risk and 77.77% were at low risk for PCOS. Most of the ones diagnosed with PCOS had a waist to hip ratio greater than 0.8 (P<0.05) and were either obese or overweight (BMI>25 kg/m2) (P<0.01), suffered from menstrual irregularities (P<0.05), hirsutism (P<0.05) and emotional problems like feeling moody and easy fatigability (P<0.05). The study reveals that PCOS is a common problem among young women that demands lifestyle modification, better awareness and early diagnosis among the masses to prevent further complications.
Extent of metabolic risk in adolescent girls with features of polycystic ovary syndrome
Fertility and Sterility, 2011
Objective: To determine prevalence of metabolic syndrome in adolescents with polycystic ovary syndrome (PCOS) and derive features suggestive of propensity for development of metabolic syndrome. Design: Prospective cohort study. Setting: Population-based cohort of adolescents in Western Australia. Participant(s): Metabolic data from 1,377 children aged 14 years, features of PCOS obtained from 244 girls aged 14 to 17 years. Intervention(s): Assessment for features of PCOS and subsequent fasting blood samples. Main Outcome Measure(s): Relationship between features of PCOS and features of metabolic syndrome.