Elastography : Novel Development in Ultrasound for the Differential Diagnosis of Thyroid Nodules (original) (raw)
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Role of Elastography in Ultrasound Evaluation of Thyroid Nodules
2017
Background: Ultrasound is the modality of choice for evaluation of thyroid nodules. Elastography plays a complimentary role in characterizing the thyroid nodules. Objectives: This study is undertaken to evaluate the role of Elastography in evaluation and characterization of the thyroid nodules. Materials and methods: Fifty cases of thyroid nodules who underwent ultrasound evaluation during March 2016 to march 2017 were included in the study. Elastography was performed during the same sitting. Ultrasound guided FNAC was performed for cytological correlation. Results: Out of the 50 patients 80% were females and 20% were males. Forty two cases were benign on FNAC and 35 of these were seen in females. Eight cases were malignant nodules. Out of the eight cases which were diagnosed as malignant, marked hypo-echogenicity, micro-calcification, intrinsic vascularity and elastography features were found to be useful in differentiating benign from malignant lesions. The sensitivity and specifi...
Ultrasound elastography in the evaluation of thyroid pathology. Current status
European Journal of Radiology, 2014
Thyroid pathology including thyroid nodules and diffuse thyroid diseases represents often a diagnosing challenge for clinicians. US, although highly accurate in identifying thyroid nodules and diffuse thyroid diseases, is still not sufficiently accurate to evaluate them. US-elastography has been introduced in order to further increase US accuracy in many fields and eventually for thyroid disease. The aim of the present paper it to provide an update of the literature on different available techniques and the results reported both for thyroid nodules differentiation and for diffuse thyroid disease evaluation. Advantages and limitations of elastography are also discussed.
Elastography in the Differential Diagnosis of Thyroid Nodules
Ultrasonic Imaging, 2014
Despite the publication of a recent meta-analysis of elastography in thyroid nodules, further work is necessary on this issue in different populations. In this study, we aimed to evaluate the clinical value of elastography on nodular goiters in mild iodine-deficient regions without excluding patients according to nodule characteristics. This prospective study was conducted between April 2010 and December 2011 in Yıldırım Beyazıt Dıskapı Research Hospital Endocrinology outpatient clinic. Five hundred twenty-eight nodular goiter patients who underwent thyroid fine-needle aspiration biopsy were included in our study. Elastography scores and indexes were measured with real-time ultrasound elastography (Hitachi® EUB 7000 HV machine with 13 MHz linear transducer). There were 471 females and 57 males and their ages ranged from 45 years to 78 years. A total of 601 nodules were evaluated in these patients. The area under the curve (AUC) for the elasto score was 0.91 ( p < 0.0001) and AUC ...
The efficiency of US elastography in the differential diagnosis of thyroid nodules
Journal of the Belgian Society of Radiology, 2015
To evaluate the efficiency of ultrasound elastography (Use) in the differential diagnosis of thyroid nodules. Methods: one hundred thyroid nodules in 100 patients (79 females, 21 males, age range 18-78; mean age = 45.6 years) were evaluated with real-time freehand Use, using hitachi eUB 7500 equipment and elasticity scores were obtained. The elasticity was scored as follows: score 1, elasticity in the entire nodule; score 2, mainly elastic nodule with the presence of inelastic areas not constant during real time examination; score 3, constant inelastic areas prevalently arranged at the periphery of the nodule; score 4, constant inelastic areas prevalently arranged at the center of the nodule; score 5, no elasticity in the nodule. also mean strain ratio values were calculated for all nodules. Results: eighty-four (86%) of cases were benign and sixteen (16%) were malignant. elasticity score 3 and higher and strain ratio higher than 2.485 had statistically significant relation with malignancy (p < 0.05). Conclusions: Use including strain ratio calculations besides subjective evaluation of elasticity scores is an efficient imaging method which may contribute to the differential diagnosis of thyroid nodules.
Real Time Ultrasound Elastography for the Differentiation of Benign and Malignant Thyroid Nodules
Open Journal of Medical Imaging, 2014
The purpose of this study was to evaluate the predictive value of real-time ultrasound elastography (RUE) in differentiating benign from malignant thyroid nodules, with fine needle aspiration cytology analysis as the reference standard. A total of 78 consecutive patients with thyroid nodules who were selected for fine needle aspiration biopsies were examined in this prospective study. 78 nodules in these patients were examined by conventional ultrasound, and ultrasound elastography. The final diagnosis was obtained from cytological findings. Tissue stiffness on ultrasound elastography was scored from 1 (low stiffness over the entire nodule) to 5 (high stiffness over the entire nodule and surrounding tissue). On real-time ultrasound elastography, 47 of 62 benign nodules (76%) had a score of 1 or 2, whereas 15 of 16 malignant nodules had a score of 3 to 5, with sensitivity of 93.7%, specificity of 90%, a positive predictive value of 71%, and a negative predictive value of 98%. Real-time ultrasound elastography is a promising imaging technique that is useful in the differential diagnosis of thyroid cancer. Utilization of ultrasound elastography could reduce the rate of thyroid biopsies because of its high elasticity being highly associated with benign cytology.
Pakistan Journal of Medical and Health Sciences, 2022
Background: Elastography is a method recently being used in the evaluation of thyroid nodules by comparing tissue elasticity. The aim of this study was to determine the diagnostic accuracy of elastography in differentiation between benign and malignant thyroid nodules, taking histopathology as gold standard. Methods: Total of 50 patients with palpable thyroid nodule of any size of age 20-60 years of either gender were included. elastography was performed in every patient by using a high resolution unit with a linear array probe centered at 7.5 MHz, elastography was performed in every patient by a consultant radiologist benign or malignant thyroid nodules was noted. Elastography findings were compared with histopathology report Results: All the patients were subjected to strain ultrasound elastography. USG supported the diagnosis of malignant thyroid nodules in all 50 patients. Histopathology confirmed malignant thyroid nodules in 46 (true positive) cases where as 4 (false positive) had no malignant lesion on histopathology. In USG negative patients, 47 were true negative while 2 were false negative. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of strain ultrasound elastography in differentiation between benign and malignant thyroid nodules, taking histopathology as gold standard is 90.0%, 90.30%, 92.31%, 94.77% and 93.18% respectively Conclusion: According to this study, strain ultrasound elastography is the non-invasive modality of choice with high diagnostic accuracy in diagnosing malignant thyroid nodules.
https://www.ijhsr.org/IJHSR\_Vol.7\_Issue.6\_June2017/IJHSR\_Abstract.06.html, 2017
Our study aimed to compare between ultrasound elastography (UE) and fine needle aspiration cytology (FNAC) in prediction of malignancy in thyroid nodules based on histopathology results. A total of 60 patients with thyroid nodules, who had an indication of thyroidectomy, were involved in this study after approval was obtained. They were selected for ultrasound elastography (UE) and fine needle aspiration before surgery. Then followed by FNA, and further with histopathology after surgery. 19 cases in elastography examination which diagnosed as benign nodules and confirmed histologically were classified as score 1and 2. The sensitivity of the elastography was 87.5% and specificity 85.7% whereas FNA showed 87.5 %, and % 96.4 for sensitivity, specificity respectively. ROC analysis showed the area under the elastography curve was 0.88 (95% confidence interval, 0.712 to 1.02) while 0.92 (95% confidence interval, 0.779 to 1.06) for FNA curve. FNA is still more reliable than ultrasound elastography, but UE is an easy, non-invasive and fast imaging technique that can help in thyroid scans to identify cases for FNA, reducing the number of unnecessary biopsies, and thus reducing risks and costs. However, future developments are needed for this promising diagnostic technique.
Role of Ultrasound Elastography in Prediction of Malignancy in Thyroid Nodules
Endocrine Research, 2012
Background. Ultrasonography is considered useful to distinguish between solid and cystic thyroid nodules and to stratify a nodule's risk of cancer as low, medium, or high. Ultrasound (US) elastography has been applied to study the hardness/elasticity of nodules to differentiate malignant from benign lesions. Elastography possibly can solve the dilemma in reaching an accurate diagnosis for the cytologically known as indeterminate nodules. Aim. To evaluate the sensitivity and specificity of US elastography in the diagnosis of thyroid cancer. Patients and methods. This prospective study included 40 patients. The total number of nodules was 46, they were all euthyroid. Laboratory investigations were done including FT 3 , FT 4 , and TSH to exclude hot nodules. Neck US, US elastography, and fine-needle aspiration were done to all patients, and US elastography scoring system from 1 to 4 was used. Results. Four out of the 46 studied nodules were malignant. The ROC curve for elastography score (E-score) showed high sensitivity, specificity for the diagnosis of malignant thyroid nodules with a cut-off value of E-score 4 and high significance (p < 0.001), the area under curve was 0.92. The sensitivity was 75.0% and specificity was 100%. For E-score more than 2, the sensitivity was 100% and specificity was 85.37%. Conclusion. US elastography can be used to increase both the sensitivity and the specificity of US for the detection of malignant thyroid nodules, and so it seems to have great potential as a new tool for the diagnosis of thyroid cancer.
American Journal of Roentgenology, 2012
Fine-needle aspiration biopsy of thyroid lesion is the preoperative screening method of choice worldwide, because it distinguishes benign and malignant lesions with high accuracy [6-8]. Because of its simplicity, low cost, and absence of major complications, it is the initial investigative technique in the management of thyroid diseases [6-8]. Real-time sonographic elastography is a newly developed dynamic imaging technique that displays tissue elasticity by measuring the degree of distortion under the application of an external force. Like palpation, sonographic elastography uses tissue deformation or strain that is caused by external compression and is based on the precompression and compression. Ultrasonographic elastography has been used to examine such organs as the breast [9, 10], thyroid [11], prostate [12], cervix [13], and liver [14]. This technique is a promising imaging technique that can be used for the differentiation of benign and malignant thyroid nodules. Howev
IIUM Medical Journal Malaysia
INTRODUCTION: Ultrasound has been widely used to assess thyroid nodules. Although ultrasound elastography has been developed to improve detection of thyroid malignancy, it has received mixed responses. This study aimed to determine the efficacy of ultrasound elastography in detecting malignant thyroid nodules. MATERIALS AND METHODS: Patients with thyroid nodules were assessed using conventional ultrasound and elastography followed by fine-needle aspiration and or hemithyroidectomy. The ultrasound findings were compared with the cytology or histopathology for statistical analysis. RESULTS: Out of 156 nodules from 92 patients included in the study, 12 (7.7%) were malignant and 144 (88.8%) were benign. The elastography was found to be an independent predictor of malignancy (OR 10.35, 95% CI [1.31, 81.6], p = 0.03). Other independent predictors were taller shape and central Doppler pattern obtained using conventional ultrasound. A combination of the three independent predictors was show...