Synthesis, Characterization and In Vitro Antitubercular and Antimicrobial Activities of new Aminothiophene Schiff Bases and Their Co(II), Ni(II), Cu(II) and Zn(II) Metal Complexes (original) (raw)

A series of di-and triorganotin 3,6-dioxaheptanoates and 3,6,9-trioxadecanoates were synthesized and characterized by IH, 13C and l7Sn NMR, electrospray mass and l9mSn M6ssbauer spectroscopy, as well as elemental analysis. Their in vitro antitumour activity against seven tumoural cell lines of human origin, two breast cancers (MCF-7, EVSA-T), a colon carcinoma (WiDr), an ovarian cancer (IGROV), a melanoma (M19 MEL), a renal cancer (A 498) and a non small cell lung cancer (H 226), is reported. They are characterized by similar inhibition doses IDs0 as the analogous di-and triorganotin derivatives of 4-carboxybenzo-15-crown-5 and-18-crown-6 and in some cases by much lower IDs0 values than clinically used reference compounds such as doxorubicine and methotrexate.