Pathways to Aggression in Schizophrenia Affect Results of Treatment (original) (raw)
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Aggression in the treatment of inpatients with schizophrenia, using the overt aggression scale
Biological Psychiatry, 1995
To investigate the relationship between aggression, clinical symptoms and biological parameters in schizophrenic patients, a retrospective chart review of 48 inpatients on a research ward was conducted. Overt Aggression Scale (OAS) ratings, BPRS ratings, plasma cholesterol, body weight, and CSF monoamine levels were collected during three treatment condi-tions~fluphenazine, placebo, and clozapine. Results include: 25 of 48 patients (52%) exhibited aggressive behavior; there were significant decreases in episodes of aggression between placebo (81 episodes), fluphenazine (19 episodes), and clozapine (3 episodes). OAS scores also declined with clozapine treatment (PBO = 11.2 _+ 13.7, FLU = 2.9 _+ 5.7, CLZ-0.36 _+ 1.0, p < 0.01); BPRS thought disorder (TD) subscale scores correlated with a number of aggressive episodes and higher OAS scores during fluphenazine and placebo condition (p < 0.0l); however, no correlation existed during clozapine treatment; patients with "high aggression" (episodes > 3, or OAS scores > 10) (n = 13), compared to patients with "low aggression" (n = 35), demonstrated younger age, lower body weight, and significant increases in CSF 5-hydroxyindoleacetic acid (5-HIAA) from fluphenazine to placebo. These data identify several predictors of aggression in schizophrenia, indicating that clozapine may have a selective effect on aggression and suggesting that aggression in schizophrenia may be mediated by different mechanisms than in other psychiatric disorders.
Background and objective: This review article aims to discuss and evaluate the risk factors for the development of violence and homicidal behaviour and the effectiveness and outcomes of the preferred atypical antipsychotics in patients diagnosed with schizophrenia. Method: For this purpose, the psychiatry literature was comprehensively reviewed. A screening of the articles in the international databases covering the period between 1970 and 2010 was performed. Results: Although the risk of homicidal behaviours is higher in patients with schizophrenia compared to the overall population, little is known about the relevant conditions triggering acts of violence among the patients with schizophrenia. The available results suggest that certain factors including some sociodemographic characteristics, young age, alcoholism, substance abuse, noncompliance with treatment, fulfillment of the criteria for antisocial personality disorder and paranoid subtype, history of suicidal ideation and attempts and history of frequent hospitalization increase the potential for violent episodes. Available data show clozapine to be the most rational therapeutic choice in preventing violent behaviour in patients with schizophrenia. There is evidence from randomized controlled trials in support of the specific anti-aggressive effect of clozapine. Conclusion: In clinical practice, patients with a risk of committing homicide should be detected and monitored closely. There are many trials showing the efficacy of clozapine on violent and aggressive behaviour.
Psychopharmacology of Aggression in Schizophrenia
Schizophrenia Bulletin, 2011
The management of aggression in patients with schizophrenia is a complex and challenging clinical dilemma. It also is greatly influenced by prevailing societal and medicolegal considerations regarding the perceived associations between violence and mental illness. This article provides a succinct account of a complex area and offers evidence for available treatments to reduce the occurrence of violent behavior among patients with schizophrenia.
Preventing Violence in Patients with Schizophrenia
Current Treatment Options in Psychiatry, 2015
Violence in patients with schizophrenia has garnered substantial public attention in the lay press. Although schizophrenia is associated with a modestly elevated risk for violent behavior, which is further increased by comorbid substance use disorders, most patients with schizophrenia are not violent and most violent individuals do not have schizophrenia. At present, primary prevention efforts are of theoretical interest and include attention being placed on childhood maltreatment. Research into secondary prevention, defined as the prevention of occurrence of violent behavior in persons already diagnosed with schizophrenia, has identified several risk factors including substance use and nonadherence to medication treatment. A specific antiaggressive effect of clozapine has been identified and should be considered as a treatment option for persons with schizophrenia and persistent aggressive behavior. A potential alternative to clozapine is olanzapine, based on a randomized controlled trial where although olanzapine was less efficacious than clozapine in aggression outcomes, olanzapine was more efficacious than haloperidol, and the choice of olanzapine is further supported by evidence from two large effectiveness studies, the Clinical Antipsychotic Trials of Intervention Effectiveness and the European First-Episode Schizophrenia study. Tertiary prevention, defined as the acute management of agitated and aggressive behavior, is accomplished with the use of psychological and behavioral interventions such as verbal de-escalation techniques, in combination with pharmacological agents. For persons with schizophrenia, antipsychotics are preferred. Although rapidly acting intramuscular formulations have been the mainstay for this type of treatment, oral agents such as inhaled loxapine and sublingual asenapine can be considered.
Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia
The British Journal of Psychiatry, 2008
Background Violence is an uncommon but significant problem associated with schizophrenia Aims To compare antipsychotic medications in reducing violence among patients with schizophrenia over 6 months, identify prospective predictors of violence and examine the impact of medication adherence on reduced violence Method Participants (n=1445) were randomly assigned to double-blinded treatment with one of five antipsychotic medications. Analyses are presented for the intention-to-treat sample and for patients completing 6 months on assigned medication Results Violence declined from 16% to 9% in the retained sample and from 19% to 14% in the intention-to-treat sample. No difference by medication group was found, except that perphenazine showed greater violence reduction than quetiapine in the retained sample. Medication adherence reduced violence, but not in patients with a history of childhood antisocial conduct. Prospective predictors of violence included childhood conduct problems, sub...
ABSTRACT Schizophrenia, violence and homicidal act: assessing the risks, preventive measures and place of clozapine in the treatment Objective: This review is designed to analyze the potential risk factors and preventive measures involved in homicidal behaviors in schizophrenic individuals and investigate the efficacy of clozapine in preventing these violence behaviors and evaluate the results. Method: For this purpose, the psychiatry literature was comprehensively reviewed. A screening of the articles in the international and national databases, covering the period between 1979 and 2010 was performed. Trials that have contributed to this field were also utilized. Results: Although the risk of homicidal behaviors is higher in the schizophrenic individuals compared to the overall population, little is known about the relevant conditions triggering this act of violence among criminals. The available results suggest that certain factors, including some socio-demographic characteristics, male gender, young age, alcoholism, substance abuse, incompliance with the treatment, fulfillment of the criteria for antisocial personality disorder and paranoid subtype, history of suicidal ideation and attempts, and history of frequent hospitalization increase the probability for occurrence of violent episodes. Conclusion: In the clinical practice, the patients with a risk of committing homicide should be detected and monitored closely. The available data show clozapine to be the most rational therapeutic choice in preventing the acts of violence in schizophrenics. Key words: Schizophrenia, violence, homicide, risk factors, preventive measures, clozapine
Reality or Myth? Considerations Regarding the Aggressiveness of Patients with Schizophrenia
Postmodern Openings, 2014
Schizophrenia is one of the most invalidating mental disorders due to its onset at an early age, the long term evolution, and the negative impact on the social, professional and relational life. The correlation between schizophrenia and violence is very complex and only partially predicted by symptomatology, an important role being played by family and social factors.
Factors Affecting Aggressive Behavior among Patients with Schizophrenia
Egyptian Journal of Health Care, 2022
Background: Acts of violence and aggression committed by patients with schizophrenia is a major public health concern affecting patients, their families, treating clinicians as well as the community at large. The aim of the study: was to assess factors affecting aggressive behavior among patients with schizophrenia. Descriptive design was used to achieve the aim of this study. Setting: El-Abbasia Mental Health Hospital. Subject: A convenience sample of 135 patients who were hospitalized at above mentioned setting. Tools: Data were collected using structured interview questionnaire tools, first tool was consisted of two parts to assess socio-demographic, clinical characteristics and second tool was to assess factors affecting aggressive behavior among patients with schizophrenia. Results: Majority of studied patients experience aggressive behavior inside the hospital, verbal aggression was the most common form of aggression inside the hospital, less than three fifth of patients with aggressive behavior was affected by moderate risk of static factors, less than three fifth of studied patients was affected by moderate risk of clinical and dynamic factors. Two third of patients with aggressive behavior was affected by mild risk of health team related factors and moderate risk of unit and environmental related factors. Conclusion: All the patients with schizophrenia understudy engaged in aggressive behaviors in the hospital at least twice and the most common type of aggressive behavior among them was verbal aggression .There are several factors that can affect and contribute to aggressive behavior among patients with schizophrenia including static factors, clinical and dynamic factors, health team related factors, unit and environmental related factors. Recommendations: This study recommended that the necessity for training staff nurse to deal with aggressive behaviors and to know when and how the use of coercive interventions, which might reduce recourse to seclusion and restraints.
The pharmacological management of violence in schizophrenia: a structured review
Expert Review of Neurotherapeutics, 2011
Although the increased risk of violent behavior in individuals with schizophrenia is now wellestablished, there is considerable uncertainty in pharmacological strategies to reduce this risk. In this review, we performed a systematic search of three electronic databases from January 2000 to March 2010 of treatment research on the management of violence in schizophrenia. We identified eight randomized controlled trials. The main findings included the association of nonadherence to antipsychotic medication to violent outcomes, a specific anti-aggressive effect of clozapine and short-term benefits of adjunctive b-blockers. There was little evidence on the efficacy of adjunctive mood stabilizers, depot medication or electroconvulsive therapy. Future research should use validated outcomes, longer follow-up periods and investigate patients with comorbid substance misuse.
CNS Spectrums, 2014
ObjectiveA number of studies have demonstrated the anti-aggressive properties of clozapine in schizophrenia and its positive effect in borderline personality disorder. There is no published literature on the treatment of antisocial personality disorder (ASPD) with clozapine. We present a case series of 7 patients with primary ASPD and high psychopathic traits treated with clozapine, having a significant history of serious violence and currently detained in a UK based high-security hospital.MethodsA retrospective review of case notes was carried out to formulate Clinical Global Impression (CGI) scores and record incidents of violence and aggression. Effect on specific symptom domains (cognitive-perceptual, impulsive-behavioural dyscontrol, affective dysregulation) was also noted. Metabolic parameters and serum clozapine levels were also sampled.ResultsAll 7 patients showed significant improvement on clozapine. It was shown to benefit all symptom domains, especially impulsive behavior...