RasGRP is essential for mouse thymocyte differentiation and TCR signaling (original) (raw)

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

Nature Immunology

Abstract

The Ras signaling pathway plays a critical role in thymopoiesis and T cell activation, but the mechanism of Ras regulation is controversial. At least one mode of Ras regulation in T cells involves the messenger diacylglycerol (DAG). RasGRP, a Ras activator with a DAG-binding C1 ...

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