Coronary artery calcium evaluation by electron beam computed tomography and its relation to new cardiovascular events (original) (raw)
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Cardiovascular Radiation Medicine, 2004
Objective: The objective of this study was to determine the clinical and angiographic profile of patients with extremely high coronary artery calcium scores (CACS; z1000) by electron beam computed tomography (EBCT). Methods: All patients at Rush University Medical Center who had a calcium score z1000 and a coronary angiogram performed from 1997 to 2002 were identified using a prospectively collected database. The baseline demographics, symptom status, and degree of coronary stenosis by angiography and subsequent rate of coronary intervention were compared with that of patients with calcium scores b1000. Results: The clinical and angiographic profile of patients with severe coronary calcification, detected by EBCT, revealed that patients with scores z1000 had a significantly higher prevalence of coronary stenosis z50% compared with patients with scores b1000 (97% vs. 57%, P b.001). The group with CACS z1000 was more likely to be male (90% vs. 75%, P = .027) and was older (64F8 vs. 59F10, P = .001) compared with the group with less severe calcification. Although there was a significantly higher rate of luminal stenosis detected by coronary angiography in the cohort with CACS z1000, there was no difference in subsequent percutaneous coronary intervention (PCI) and utilization of intracoronary stents between the two groups. Conclusions: A markedly elevated coronary calcium score ( z1000) is correlated with increasing age and is associated with an increased likelihood of coronary stenosis z50%. However, the decision to perform coronary angiography in patients with severe coronary calcification should not be based solely on these findings, but should remain primarily dependent on the degree of ischemia detected by clinical and functional assessment. D 2004 Elsevier Inc. All rights reserved.
Predictors of aortic and coronary artery calcium on a screening electron beam tomographic scan
The American Journal of Cardiology, 2003
E lectron beam tomography offers an opportunity to noninvasively identify atherosclerotic disease via visualization of calcified plaques and facilitates the study of the relation between various risk factors and the development of atherosclerosis. Additionally, the utility of coronary calcium as a risk stratification tool is receiving marked attention. In the present study, we performed electron beam tomographic (EBT) scans of the coronary arteries and the entire aorta in 245 subjects who were asymptomatic for coronary artery disease. We intended to analyze the contribution of several risk factors to the development of medium-and large-size vessel atherosclerosis and study the relation of disease in these 2 territories.
Coronary artery calcium volume scores on electron beam tomography in 12,936 asymptomatic adults
The American Journal of Cardiology, 2004
We developed age-and gender-specific normative tables of calcium volume scores by using data from 12,936 asymptomatic patients who underwent electron beam tomographic scanning and compared the volume with the Agatston scores obtained in the same subjects. The 2 scores increased as the number of atherosclerotic risk factors increased. The volume scores were statistically smaller than the Agatston scores at the upper quartile level.
Radiology, 1998
To assess the variability and reproducibility of a volumetric calcium score calculated with electron-bean computed tomographic (CT) scans of coronary arteries. Two sets of electron-beam CT scans were obtained in patients with coronary calcification (group A) or known risk factors for coronary arterial disease (group B). The second set or scans was obtained after a brief interval (group A, n = 52) or after 1 year with no risk modification (group B, n = 27). Traditional (plaque area and attenuation) and volumetric calcium scores were calculated for each patient and lesion. The median percentage change for individual lesions in group A was 13% for the volumetric and 19% for the traditional score. The overall reduction in error with the volumetric score was 40% (P < .001). The median percentage change for group A patient totals was 9% for the volumetric and 15% for the traditional score (P < .001). In group B patients, the median volumetric score increased by 44% after 1 year. The...
The American Journal of Cardiology, 2004
This angiographically correlated study reports on, for the first time, age-and gender-based distribution of the volumetric calcium score in a large group of patients with suspected coronary artery disease. Volumetric calcium data predicted significant coronary artery disease (>50% lumen diameter stenosis) as well as the traditional Agatston score. Exclusion of any calcium was highly accurate in ruling out obstructive disease in symptomatic subjects >50 years of age. ᮊ2004 by Excerpta Medica, Inc.
Coronary Artery Calcium Score: A Review
Iranian Red Crescent Medical Journal, 2013
Context: Coronary artery disease (CAD) is the foremost cause of death in many countries and hence, its early diagnosis is usually concerned as a major healthcare priority. Coronary artery calcium scoring (CACS) using either electron beam computed tomography (EBCT) or multislice computed tomography (MSCT) has been applied for more than 20 years to provide an early CAD diagnosis in clinical routine practice. Moreover, its association with other body organs has been a matter of vast research. Evidence Acquisition: In this review article, techniques of CACS using EBCT and MSCT scanners as well as clinical and research indications of CACS are searched from PubMed, ISI Web of Science, Google Scholar and Scopus databases in a time period between late 1970s through July 2013 and following appropriate selection, dealt with. Moreover, the previous and ongoing research subjects and their results are discussed. Results: The CACS is vastly applied in early detection of CAD and in many other research fields. Conclusions: CACS has remarkably changed the screening techniques to detect CAD earlier than before and is generally accepted as a standard of reference for determination of risk of further cardiac events.