Keratocystic Odontogenic Tumour: Current concepts, theory and presentation of 2 contrasting cases (original) (raw)
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A Narrative Review on the Most Important Management of Keratocystic Odontogenic Tumor
2021
The term odontogenic keratocyst' (OKC) was first described by Philipsen in 1956 [1]. The World Health Organization (WHO) used the term keratocystic odontogenic tumor (KCOT) as benign but aggressive tumor of odontogenic origin in 2005. Histologically, KOT is characterized by a thin parakeratinized stratified epithelium. KCOT is a benign neoplasm with a keratinized epithelial outline with a high recurrence rate [2]. KOT is a relatively common developmental odontogenic cyst and represents approximately 10-14% of all jaw cysts [3]. The reason for the high recurrence rate in KCOT is due to its neoplastic characteristics including high proliferation rate, angiogenesis, presence of daughter cysts and epithelial islands [4, 5]. Incomplete resection of epithelial structure of KCOT due to the fragility of the tumor tissue is another reason for recurrence [4, 6]. In radiographic imaging, KCOT is seen as aunilocular or multilocular well-circumscribed radiolucent lesion with scalloped and co...
Keratocystic Odontogenic Tumour : A Review of Literature
2014
Keratocystic odontogenic tumors (KCOTs) comprise a unique pathological entity characterized by aggressive/destructive behavior and propensity to recurrence. There are many types of tumours of the jaws, but what makes the kcot unusual are its characteristic histopathological and clinical features, including potentially aggressive behaviour, high recurrence rate, and an association with the nevoid basal cell carcinoma syndrome. Keratocystic odontogenic tumour is a locally aggressive tumour affecting the maxilla and mandible. The purpose of this paper is to review the features and behaviour of the odontogenic keratocyst, now officially
Diagnostic and treatment features of keratocystic odontogenic tumors
Stomatos, 2013
Keratocystic odontogenic tumors (KCOT) comprise a unique pathological entity characterized by aggressive/destructive behavior and propensity to recurrence. This study describes the diagnostic and treatment features of a KCOT lesion. A 22-year old man was referred for surgical treatment of pericoronitis on tooth no. 37. Panoramic radiography revealed a unilocular, large radiolucent area extending from tooth no. 36 to the left mandibular ramus. Aspiration and incisional biopsy were performed, and the tissue sample was sent for microscopic evaluation. Microscopically, a cystic lesion was observed, lined by keratinized squamous epithelium and fi lled with keratin lamellae, confi rming the diagnosis of KCOT. Surgery was performed in an outpatient setting and involved osteotomy, detachment of the cystic lesion, and removal of teeth no. 36, 37, and 38. The patient was clinically and radiographically followed for 12 months, and no evidence of recurrence was observed. KCOTs should be considered in the differential diagnosis of lesions affecting the posterior region of the mandible. Accurate clinical, radiographic, and microscopic examinations are essential to establish the defi nitive diagnosis and choose the most effective therapy.
A review on the most important management of keratocystic odontogenic tumor
Klinicka onkologie, 2022
Background: Keratocystic odontogenic tumor (KCOT) is a recurrent benign tumor with a keratinized epithelial shape. The treatment methods in KCOT are still debated. The aim of all treatment methods is to eradicate the cyst and to reduce recurrence and surgical complications. This review article was conducted to assess the findings of studies on the dia gnosis, management and recurrence of KCOT. Methods: Information were gathered by searching keywords such as management, treatment, pharmacology, surgery and keratocystic odontogenic tumor in international databases such as Web of Science, PubMed and Scopus. The search period was between 2010-2020. Results: Techniques used for the treatment include decompression, marsupialization, enucleation with or without adjunct, Caldwell-Luc surgery and resection. Of the 40 studies, recurrence was observed in 13 studies and the recurrence ranged from 0 to 48% in different treatment methods. Conclusion: Due to the high recurrence of this disease, it is suggested that long term follow-up be considered after treatment to reduce recurrence. Decision on the treatment should be made considering age, tumor size, and the site of involvement in order to reduce the economic and psychological burden of the disease.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015
Keratocystic odontogenic tumour (KCOT)/ Odontogenic keratocyst (OKC) is a clinicopathologically distinct form of odontogenic cyst, known for its pathognomic microscopic features, aggressiveness and high recurrence rate [1]. The frequency of OKC has been reported to vary from 3% to 11% of odontogenic cysts [2]. OKC is one of the most aggressive odontogenic cysts owing to its relatively high recurrence rate and tendency to invade adjacent tissues [3]. This lesion is now categorized as an odontogenic tumour according to latest WHO recommendations because of its aggressiveness, infiltrative nature and mitotic activity of the epithelial cells which is greater than that of other odontogenic jaw cysts [4].
Keratocystic odontogenic tumour -An unusual presentation
IP Innovative Publication Pvt. Ltd., 2017
Keratocystic Odontogenic Tumour (KCOT) is one of the most controversial odontogenic tumor which remains an enigma to the world of dentistry, because of its varied biological behaviour. Initially, it was considered as a cyst but in 2005, WHO reclassified it as keratocystic odontogenic tumor because of its aggressive & recurrent behaviour & placed it in the categories of odontogenic tumors. Histopathologically it has pathognomonic appearance, but in some cases, it may show unusual histopathological presentation & can be confused with other cystic odontogenic tumors. Hard tissue formation in KCOT capsule & presence of Rushton bodies are an uncommon findings. Herewith, we report a case of 26 year old male patient with an unusual histopathologic presentation of KCOT mimicking unicystic ameloblastoma (UAB) at places & also showing Rushton bodies, areas of calcification & darkly stained cells within the capsule.
Keratocystic Odontogenic Tumor ( KCOT ) in Maxillary Sinus arising from an Infected Dentigerous Cyst
2017
Keratocystic odontogenic tumor (KCOT) is one of the most aggressive odontogenic pathology, which is now being considered more as a benign tumor rather than it's previously known name Odontogenic Keratocyst (OKC). It's aggressive nature is attributed to its high recurrence rate. Its typical feature shows a thin, friable wall, which is often difficult to enucleate from the bone in one piece as many times it has multiple adhesions known as small satellite cysts within the fibrous wall. At times, it is also associated with bifid-rib basal cell nevus syndrome (Gorlin syndrome). Multiple surgical approaches were introduced including decompression, marsupilization, enucleation with or without adjunct (Carnoy's solution, enucleation), wide local resection followed by reconstruction. Many treatment modalities have been advocated for its management, but still its specific management is debatable. Considering its unpredictable and higher recurrence rate, WHO in 2005 categorized it ...
A recurrence case of keratocystic odontogenic tumor
International Journal of Medical and Dental Case Reports
Keratocystic odontogenic tumor is a rare, benign, intraosseous tumor of odontogenic origin with a potential of aggressive and infiltrative behavior. It shows specific histopathological features, and follow-up is characterized by a high rate of recurrence. Moreover, therefore, to reduce the chances of recurrences, along with the surgical modalities like enucleation, chemical and thermal cauterization may be used to deal with the problem of satellite microcysts. We present a case of odontogenic keratocyst with recurrence in a 60-year-old male who reported with the chief complaint of pain in left mandible.