{"content"=>"Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl--substituted amino- and 5-benzoyl--sulfonylamino-4-alkylsulfanyl-2-pyridones.", "i"=>[{"content"=>"N"}, {"content"=>"N"}]} (original) (raw)

2017, Drug design, development and therapy

The present research describes the synthesis of novel 5-benzoyl--substituted-amino- and 5-benzoyl--sulfonylamino-4-alkylsulfanyl-2-pyridones-and-via the reaction of 2-benzoyl-3,3-bis(alkylthio)acrylonitriles-with-cyanoacetohydrazideand cyanoaceto--phenylsulfonylhydrazide, respectively. Also, the reactivity of the compounds-toward hydrazine hydrate to give product 1-pyrazolo[4,3-]pyridine derivativewas studied. In addition, the reactivity of the-toward 1-cyanoacetyl-4 arylidenesemicarbazides-afforded 3,5-dihydro[1,2,4]triazolo[1,5-]pyridine-6-carbonitrile derivatives (-)-, which reacted with hydrazine hydrate to give 3-pyrazolo[4,3-][1,2,4]triazolo[1,5-]pyridine-6-carbonitrile derivatives-. The structures of the new products were characterized based onH nuclear magnetic resonance,C nuclear magnetic resonance, infrared, mass-spectroscopy, and elemental analyses. The products were screened in vitro for their antibacterial and antifungal activity properties.