Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines (original) (raw)

Organic & Biomolecular Chemistry, 2002

Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved …

Org. Biomol. Chem …, 2002

Oxetane modified antisense oligonucleotides promote RNase H cleavage of the complementary RNA strand in the hybrid duplex as efficiently as the native, and offer improved endonuclease resistance

Journal of the Chemical Society, Perkin Transactions 2, 2001

Mixed backbone antisense oligonucleotides: design, biochemical and biological properties of oligonucleotides containing 24-54-ribo- and 34-54-deoxyribonucleotide segments

adrienne manning

Comparison of the RNase H Cleavage Kinetics and Blood Serum Stability of the North -Conformationally Constrained and 2‘Alkoxy Modified Oligonucleotides

oommen varghese

Biochemistry, 2007

Chemically modified oligonucleotides with efficient RNase H response

Patrick Hrdlicka

Bioorganic & Medicinal Chemistry Letters, 2008

2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo

Nucleic Acids Research, 2004

5'-,3'-Inverted Thymidine-modified Antisense Oligodeoxynucleotide Targeting Midkine. ITS DESIGN AND APPLICATION FOR CANCER THERAPY

Hiroshi Itoh

Journal of Biological Chemistry, 2002

Zwitterionic oligonucleotides with 2′-O-[3-(N,N-dimethylamino)propyl]-RNA modification: synthesis and properties

Tetrahedron Letters, 2000

Conformationally Constrained 2‘- N ,4‘- C -Ethylene-Bridged Thymidine (Aza-ENA-T): Synthesis, Structure, Physical, and Biochemical Studies of Aza-ENA-T-Modified Oligonucleotides

Oommen Varghese

Journal of the American Chemical Society, 2006

RNase H-independent antisense activity of oligonucleotide N34P54 phosphoramidates

Sergei Gryaznov

Nucleic Acids Research - NAR

Synthesis of Oligodeoxynucleotides Containing 2-Substituted Guanine Derivatives Using 2-Fluoro-2'-Deoxyinosine as Common Nucleoside Precursor

Ramon Eritja

Nucleos Nucleot Nucleic Acids, 1997

Studies of a Chemically Modified Oligodeoxynucleotide Containing a 5-ATOM Amide Backbone Which Exhibits Improved Binding to Rna

George Minasov

Nucleosides, Nucleotides and Nucleic Acids, 2001

Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-( N Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′- O ,4′- C -Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Chris Black

Journal of Medicinal Chemistry, 2010

Remarkable enhancement of binding affinity of Heterocycle-modified DNA to DNA and RNA. Synthesis, characterization and biophysical evaluation of N2-imidazolylpropylguanine and N2-imidazolylpropyl-2-aminoadenine modified oligonucleotides

Dan Cook

Tetrahedron Letters, 1994

An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers

John Bisi

Nucleic Acids Research, 1995

Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules

Cezary Swider

Nucleic Acids Research, 2004

2‘- O -[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2‘- O -[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA †

Biochemistry, 2002

Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl (2′-O-AOE) modified oligonucleotides

Tetrahedron Letters, 1999

Endowing RNase H-Inactive Antisense with Catalytic Activity: 2-5A-Morphants ⊥

IJETM Journal

Bioconjugate Chemistry, 2005

The evaluation of 2′- and 6′-substituted carbocyclic nucleosides as building blocks for antisense oligonucleotides

Marc-olivier Bévièrre, Alain Mesmaeker

Bioorganic & Medicinal Chemistry Letters, 1995

Synthesis, Hybridization, and Nuclease Resistance Properties of 2'-O-AMINOOXYETHYL Modified Oligonucleotides

Nucleos Nucleot Nucleic Acids, 1999

A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H

Journal of Biochemical and Biophysical Methods, 2001

Synthesis and RNA-selective hybridization of α-l-ribo- and β-d-lyxo-configured oligonucleotides

Torsten Bryld

Tetrahedron, 2006

Design, biochemical, biophysical and biological properties of cooperative antisense oligonucleotides

adrienne manning

Nucleic Acids Research, 1995

Synthesis and Properties of RNA Analogues Having Amides as Interuridine Linkages at Selected Positions

Erika Bizdena

Journal of the American Chemical Society, 2003

Targeting RNA for Degradation with a (2', 5')-Oligoadenylate Antisense Chimera

Aimin Zhou

Nucleosides, Nucleotides and Nucleic Acids, 1995

Functionalization of the 3′-Ends of DNA and RNA Strands with N-ethyl-N-coupled Nucleosides: A Promising Approach To Avoid 3′-Exonuclease-Catalyzed Hydrolysis of Therapeutic Oligonucleotides

Montserrat Terrazas, Ignacio Faustino, Ramon Eritja, Modesto Orozco

ChemBioChem, 2013

Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides

Erich Koller

ACS Chemical Biology, 2015

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties

Valentin Vlasov

Proceedings of the National Academy of Sciences of the United States of America, 2019

Antisense Recognition of the HER-2 mRNA: Effects of Phosphorothioate Substitution and Polyamines on DNA·RNA, RNA·RNA, and DNA·DNA Duplex Stability †

veena vijayanathan

Biochemistry, 2005