Physiological Dysregulation Predicted Poorer Health and Lower Survival in a Survey of the Older Population (original) (raw)

Abstract

Objective: We investigate whether a multi-system measure of physiological dysregulation based on 16 biological measures is associated with deterioration in physical and mental health over a three-year period.

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References (20)

  1. Seplaki CL, Goldman N, Glei D, Weinstein M. A comparative analysis of measurement approaches for physiological dysregulation in an older population. Exp Gerontol 2005;40(5):438-449.
  2. Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS. Price of adaptation--allostatic load and its health consequences. MacArthur Studies of Successful Aging. Arch Intern Med 1997;157(19):2259-2268.
  3. Seplaki CL, Goldman N, Weinstein M, Lin YH. How are biomarkers related to physical and mental well-being? J Gerontol A Biol Sci Med Sci 2004;59(3):201-217.
  4. Vanitallie TB. Stress: a risk factor for serious illness. Metab Clin Exp 2002;51(6 Suppl 122035838):40-5.
  5. Karlamangla AS, Singer BH, McEwen BS, Rowe JW, Seeman TE. Allostatic load as a predictor of functional decline. J Clin Epidemiol 2002;55(7):696-710.
  6. Seeman TE, McEwen BS, Rowe JW, Singer BH. Allostatic load as a marker of cumulative biological risk: MacArthur Studies of Successful Aging. Proc Natl Acad Sci U S A 2001;98(8):4770-4775.
  7. Singer B, Ryff CD, Seeman T. Operationalizing allostatic load. In: Schulkin J, editor.
  8. Allostatis, Homeostasis, and the Costs of Physiological Adaption. Cambridge, UK: Cambridge University Press; 2005:113-149.
  9. Goldman N, Lin IF, Weinstein M, Lin YH. Evaluating the quality of self-reports of hypertension and diabetes. J Clin Epidemiol 2003;56(2):148-154.
  10. Seeman T, Glei D, Goldman N, Weinstein M, Singer B, Lin YH. Social relationships and allostatic load in Taiwanese elderly and near elderly. Soc Sci Med 2004;59(11):2245-2257.
  11. Goldman N, Glei DA, Seplaki C, Liu IW, Weinstein M. Perceived stress and physiological dysregulation in older adults. Stress 2005;8(2):95-105.
  12. Boey KW. Cross-validation of a short form of the CES-D in Chinese elderly. Int J Geriatr Psychiatry 1999;14(8):608-617.
  13. Pfeiffer E. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. Journal of the American Geriatric Society 1975;23(10):433-441.
  14. Lezak MD. Neuropsychological Assessment, 2nd Edition. New York: Oxford University Press; 1983.
  15. Wechsler D. WAIS-R Manual. New York: Psychological Corporation; 1981.
  16. Turra CM, Goldman N, Seplaki CL, Glei DA, Lin YH, Weinstein M. Determinants of mortality at older ages: The role of biological markers of chronic disease. Population and Development Review 2005;31(4):677-701.
  17. StataCorp. Stata Statistical Software: Release 8.0. College Station, TX: StataCrop LP; 2003.
  18. Long JS, Freese J. Regression Models for Categorical Dependent Variables using Stata. College Station, TX: Stata Press; 2006.
  19. McEwen BS, Seeman T. Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load. Ann N Y Acad Sci 1999;896:30-47.
  20. McEwen BS. Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging 2002;23(5):921-939.