Systems biology and cancer (original) (raw)

The paper discusses the systems biology approach to cancer, emphasizing the inadequacies of reductionist methods in understanding multifactorial diseases. It critiques traditional views on genetic regulation and proposes alternative models, such as the probabilistic functional gene network (PFGN) and cell regulation frameworks, to better account for the complexity of cancer. The work highlights the need for reassessing fundamental biological concepts and suggests that a systems-level perspective could provide insights into the mechanisms underlying cancer development and other complex traits.