Probable metastatic carcinoma with lymphoadenopathy and acquired Horner’s Syndrome portrayed in a 3rd Century CE Roman bust (original) (raw)
Related papers
A probable case of metastatic carcinoma in the medieval Netherlands
International journal of paleopathology, 2018
Despite recent considerable gains, our knowledge of cancer in antiquity is still limited. This paper discusses an adult individual from a Dutch medieval hospital site who demonstrates osteoblastic and osteolytic lesions on the ribs, scapula, clavicle, and vertebrae. The morphology, radiographic appearance, and distribution of the skeletal lesions suggest that this individual was affected by metastatic carcinoma. This case increases the number of publications that present an osteoblastic and osteolytic response to cancer and contributes to the body of evidence for archaeological neoplastic disease. For the Netherlands, this individual presents the first published case of probable metastatic carcinoma with mixed skeletal lesions.
A Case of Lytic Metastases of a Carcinoma from the Ossuary at Hallstatt (Upper Austria)
Anthropologie, 2018
A cranium of a mature male (45-55 years) from a charnel house in Hallstatt, Upper Austria (set up in the 12 th century and in use until modern times) exhibits multiple perforations that were most probably caused by a malignant tumour. The lesions vary between 44 and 4 millimetres in diameter and concern nearly all parts of the cranium (frontal, parietal, and occipital bone, maxilla), hereby pertaining to all cranial layers to a different degree. Osteolytic changes accompanied by some sclerotic bone formations are indicative of an active as well as chronic process at the time of death of the individual. Differential diagnosis was carried out by macroscopic inspection, the use of conventional radiography, computed tomography and scanning electron microscopy in the secondary electron-and backscattered electron-mode. Pathology-mimicking effects, diagenetic, and taphonomic damage as causative processes can be excluded. The same applies for various infectious diseases (mycotic, bacterial, tuberculous conditions) as well as several tumorous forms (Langerhans-cell histiocytosis, bone angioma, medullary plasmocytoma). The palaeopathological and clinical diagnostical criteria used suggest a secondary carcinoma. KEY WORDS: Metastatic carcinoma-Cranium-Hallstatt charnel house-Austria-Modern times-Differential diagnosis by CT and SEM PROLOGUE It is well known that Eugen Strouhal, physician and expert in a very broad variety of medical historical, archaeological, egyptological and anthropological, palaeopathological studies, was particularly interested in the history and paleopathology of neoplastic diseases. According to Zink (2012) "his deep interest in this topic was already apparent in his early publications on different neoplasms in ancient Egyptian remains" (Strouhal 1976, 1978a, b).
Medieval example of metastatic carcinoma: A dry bone, radiological, and SEM study
American Journal of Physical Anthropology, 1992
A n elderly male skeleton from medieval Canterbury displayed evidence of DISH and metastatic carcinoma. The dry bone findings, SEM, and radiography suggest a primary focus in the prostate. A review of the palaeopathological literature has shown that such a finding is extremely rare in archaeological remains. This is the first reported case of prostatic carcinoma from medieval England. Q
Skeletal Metastatic Carcinomas from the Roman Period (1st to 5th Century AD) in Hungary
Pathobiology, 2014
sex and age of the individuals, the most probable diagnostic option is prostate carcinoma with skeletal metastases. Conclusions: In view of the scarcity of cancer metastases that have been diagnosed in archeological specimens in general, identification of all examples of cancer in antiquity represents an important contribution both to paleopathology and to modern medicine.
Cancer, one of the world's leading causes of death today, remains almost absent relative to other pathological conditions, in the archaeological record, giving rise to the conclusion that the disease is mainly a product of modern living and increased longevity. This paper presents a male, young-adult individual from the archaeological site of Amara West in northern Sudan (c. 1200BC) displaying multiple, mainly osteolytic, lesions on the vertebrae, ribs, sternum, clavicles, scapulae, pelvis, and humeral and femoral heads. Following radiographic, microscopic and scanning electron microscopic (SEM) imaging of the lesions, and a consideration of differential diagnoses, a diagnosis of metastatic carcinoma secondary to an unknown soft tissue cancer is suggested. This represents the earliest complete example in the world of a human who suffered metastatic cancer to date. The study further draws its strength from modern analytical techniques applied to differential diagnoses and the fact that it is firmly rooted within a well-documented archaeological and historical context, thus providing new insights into the history and antiquity of the disease as well as its underlying causes and progression.
PLoS ONE, 2014
Cancer, one of the world's leading causes of death today, remains almost absent relative to other pathological conditions, in the archaeological record, giving rise to the conclusion that the disease is mainly a product of modern living and increased longevity. This paper presents a male, young-adult individual from the archaeological site of Amara West in northern Sudan (c. 1200BC) displaying multiple, mainly osteolytic, lesions on the vertebrae, ribs, sternum, clavicles, scapulae, pelvis, and humeral and femoral heads. Following radiographic, microscopic and scanning electron microscopic (SEM) imaging of the lesions, and a consideration of differential diagnoses, a diagnosis of metastatic carcinoma secondary to an unknown soft tissue cancer is suggested. This represents the earliest complete example in the world of a human who suffered metastatic cancer to date. The study further draws its strength from modern analytical techniques applied to differential diagnoses and the fact that it is firmly rooted within a well-documented archaeological and historical context, thus providing new insights into the history and antiquity of the disease as well as its underlying causes and progression.
Cancer, one of the world's leading causes of death today, remains almost absent relative to other pathological conditions, in the archaeological record, giving rise to the conclusion that the disease is mainly a product of modern living and increased longevity. This paper presents a male, young-adult individual from the archaeological site of Amara West in northern Sudan (c. 1200BC) displaying multiple, mainly osteolytic, lesions on the vertebrae, ribs, sternum, clavicles, scapulae, pelvis, and humeral and femoral heads. Following radiographic, microscopic and scanning electron microscopic (SEM) imaging of the lesions, and a consideration of differential diagnoses, a diagnosis of metastatic carcinoma secondary to an unknown soft tissue cancer is suggested. This represents the earliest complete example in the world of a human who suffered metastatic cancer to date. The study further draws its strength from modern analytical techniques applied to differential diagnoses and the fact that it is firmly rooted within a well-documented archaeological and historical context, thus providing new insights into the history and antiquity of the disease as well as its underlying causes and progression.
Case of metastatic carcinoma from end of the 8th–early 9th century Slovakia
American journal of …, 2001
The first case of metastatic carcinoma ever detected in Slovakia comes from a Slavonic cemetery at Borovce, in the district of Piešt'any, which is dated from the end of the 8th to the middle of the 12th century AD. The disease afflicted a 50 -60-year-old male, buried in a grave from the older phase of inhumation (8th-early 9th century AD). A number of osteolytic metastases were found in all bones of the skull and postcranial skeleton except for the forearms, hands, lower legs, and feet. They were studied macroscopically by standard X-rays, and by scanning electron microscopy and laser scanning confocal microscopy. Analogous finds from Central European countries were also obtained. They are discussed in relation to their chronology, which shows a tendency of increasing occurrence culminating in the Middle Ages. Some demographic and paleopathological characteristics of the burials in the Borovce cemetery are also provided. Am J Phys Anthropol 116: 216 -229, 2001.