Comparative Evaluation of the Binding Properties of Two Species of Khaya Gum Polymer in a Paracetamol Tablet Formulation (original) (raw)

2008, Pharmaceutical Development and Technology

A study was made of the comparative effects of polymers obtained from two species of khaya tree -Khaya senegalensis and Khaya grandifoliola -as binding agents in a paracetamol tablet formulation. The mechanical properties of the tablets were assessed using the tensile strength (T), brittle fracture index (BFI) and friability (F) of the tablets while the drug release properties of the tablets were assessed using disintegration and dissolution times. The tensile strength, disintegration and the dissolution times of tablets increased with the increase in binder concentration while F and BFI decreased. K. senegalensis gum produced tablets with stronger mechanical properties with less tendency to laminate, and longer disintegration and dissolution times than K. grandifoliola gum. The results suggest that the polymer gum from K. senegalensis will be more appropriate as a binding agent than the gum from K. grandifoliola when higher mechanical strength and slower release profiles of tablets are desired.

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