Structure, transmission, diagnostic symptoms, host and entry mechanism of covid-19: A review (original) (raw)

Coronaviruses

Abstract

:: In Wuhan, China, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported and caused coronavirus disease 19 (COVID-19). The infection of coronavirus is pathogenic and highly transmittable which spread quickly around the world by human to human contact. Through genomic analysis it has been revealed that primary reservoir of SARSCoV-2 are bats due to having severe acute respiratory syndrome-like (SARS-like) viruses phylogenetically. The viral infection rapidly transmitted by human to human contact but the intermediate source of their origin and transfer is not known. Till date, any clinically approved vaccine or antiviral drug is not prepared against COVID-19. However, researchers and scientist have been evaluated some broad-spectrum of antiviral drugs against COVID-19 through clinical trials and found satisfactory clinical recovery. This review summarise the comparative analysis of the emergence and pathogenicity of COVID-19, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). This review also focused to development of effective vaccines or antidrug and also focused on an approach to practice therapeutic combinations to fight with this viral outbreak.

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