In vitro Antimicrobial Activity of the Chemical Ingredients of Ranunculus hirtellus (original) (raw)
The phytochemical study on the n-butanol fraction of Ranunculus hirtellus led to the first time isolation of four known constituents (1-4).The antimicrobial and enzyme inhibition activities of these four constituents isolated from Ranunculus hirtellus are presented in this study. These constituents were screened against two human Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus) and four Gram-negative ones (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella Pneumoniae) by using Agar well diffusion method for both antibacterial and antifungal activities. MIC was determined by Agar well dilution method. MBC was performed by viable cell count method. Compound (1) showed maximum antimicrobial activity while the other compounds showed least antimicrobial activities. In addition these four isolated compounds were screened for their Acetyl cholinesterase (AChE) and Butyryl cholinesterase (BChE) inhibitory activities. Moreover, the IC (50% inhibitory...
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