Gastric bulging confirmed as a pancreatic solid pseudopapillary tumor by endoscopic ultrasound-guided fine needle aspiration (original) (raw)
Related papers
Acta cytologica
Solid pseudopapillary tumor of the pancreas (SPTP) is an exceedingly rare pancreatic tumor. We present the clinical, endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) cytologic features and immunohistochemical findings performed on cell blocks of 3 SPTPs. Three females (17-32 years old) were admitted to our hospital due to unexplained episodic abdominal pain. EUS confirmed the presence of a mass in the body and tail of the pancreas (2 cases) and in the head (1 case), with distinct borders and occassional dilation of the peripheral part of the pancreatic duct. EUS-FNA cytology specimens consisted of single cells and aggregates of uniform polyhedral cells, forming branching papillary clusters with delicate fibrovascular cores and nuclear overlapping (2 cases) and glandlike structures (1 case). Variable hyaline, myxoid stromal elements and naked capillaries were also seen. The cells had bland nuclear features, small nucleoli, nuclear grooves in some of them and focally cy...
Journal of Surgical Oncology, 2012
Objectve: To study clinically pathological features and origin of solid-pseudopapillary tumor of pancreas (SPT). Patients and Methods: Clinical and pathological data of 82 cases with SPT were retrospectively studied. SAS6.12 statistics package was used for analysis. P < 0.05 was regarded as statistically significant difference. Results: The SPT patients included 70 females and 12 males, with a median age of 31 years old. The mean tumor size was 6.71 AE 4.42 cm. Vascular or organs was invaded in nine cases. The clinical and pathological characteristics show no significant difference between male and female patients. In the non-encapsulate group (22 cases), the tumor was larger (P ¼ 0.0015), exogenous growth pattern (P ¼ 0.0194), and would probably involve major vascular or organs (P ¼ 1.697EÀ06). The typical features of SPT include pseudopapillary pattern with fibro vascular stalks by uniform poorly cohesive polygonal cells. The tumor cell expresses a variety of immune markers in heterogeneity. Under electron microscope, there are some electron dense granules, about 8-1.2 mm in diameter, with membrane similar to the zymogen granules in SPT cell cytoplasm. Conclusions: SPT with incomplete capsule often presents malignant behaviors. SPT shows multi-heterogeneity, which is caused by the disorder in the development of pancreatic stem cell.
Diagnostic Cytopathology, 2002
The solid-pseudopapillary tumor of the pancreas (SPTP) is an unusual low-grade malignant epithelial tumor affecting predominantly adolescent girls and young women. Although approximately 500 cases of SPTP have been described in the last 40 yr, its pathogenesis remains uncertain. However, the clinical features of this neoplasm are very characteristic and SPTP must be suspected in any young woman with a cystic or partially cystic pancreatic mass. In this report, we describe the cytologic features of seven cases of SPTP investigated by preoperative fine-needle aspirates. The analysis of the cytologic features in these cases and in 43 cases collected from the literature reveals that they are highly characteristic and quite distinct from those of other cystic or solid tumors of the pancreas. On this basis, a cytologic diagnosis of SPTP may be rendered with great confidence, not only in clinically typical examples, but also in unusual presentations, such as in older patients, in males, in ectopic locations, and in metastatic sites.
Solid Pseudopapillary Tumor of Pancreas in a 15-year-old Female: A Case Report
North American journal of medicine & science, 2019
Solid pseudopapillary tumor (SPT) is a very rare tumor accounting for only 1% of all pancreatic exocrine tumors. In this case, patient is a 15-year-old female with history of obesity and oligomenorrhea. She was admitted with a six-day history of severe upper abdominal pain, non-bloody vomiting and occasional diarrhea with no history of fever or sick contact. MRI abdominal examination with contrast showed a cystic 3.4 x 2.2 x 2.0 cm mass in the tail of the pancreas. Patient then underwent the distal pancreatectomy and splenectomy. Grossly, the tumor mass is well-circumscribed and has a tan/yellow cystic cut surface. Microscopically, most of the tumor tissue is necrotic. Sheets of cells demonstrate pseudopapillary arrangement in the preserved area. The nuclei are uniform without apparent mitotic figures and cytoplasm is moderate and eosinophilic. Immunohistochemistry study revealed that tumor cells are positive for CD10, progesterone receptor, synaptophysin and nuclear beta-catenin staining. Diagnosis of this case is challenging because extensive necrosis of the tumor tissue, however, the small areas of residual tumor still retain the pseudopapillary architecture and nested pattern. Individual tumor cells have monotonous low grade character. Immunoprofile also supports the diagnosis of solid pseudopapillary tumor.
Endoscopic Ultrasound in Solid Pseudopapillary Tumor of the Pancreas: About two Clinical Cases
Saudi journal of pathology and microbiology, 2022
Background: Solid pseudopapillary tumor of the pancreas (SPPT) or Frantz's tumor is a rare exocrine pancreatic tumor, it generally occurs among females within the second or third decade of life. The clinical symptomatology is non-specific, frequently presenting as a slowly growing abdominal mass without any biological abnormalities. The imaging usually shows a well-limited mass with little vascularity. Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) helps the diagnosis. The treatment of these tumors is surgical, and the prognosis is excellent after complete resection. We report two new cases of Frantz tumor, detailing the clinicopathological features of this rare neoplasm. Case presentation: Case 1: A 19-year-old woman presented with middle upper abdominal pain. Computed tomography (CT) scan showed a solitary encapsulated mass in the pancreatic body. Endoscopic ultrasound showed a regular, well-defined, heterogenous lesion, measuring 50 × 46 cm, in the pancreatic body. endoscopic ultrasound fine-needle aspiration was then performed with cytopathological analysis compatible with SPPT. Body computed tomography confirmed the absence of metastases and she underwent a central pancreatectomy. 12 months after the diagnosis, she remains asymptomatic, continuing regular follow-up. Case 2: A 22-year-old woman presented with epigastric pain and weight loss. CT scan revealed a single 5 cm well defined mass in the pancreatic head. EUS showed a well-defined heterogenous hypoechoic encapsulated mass in the pancreatic head, measuring 64 × 44 mm; EUS-FNA was performed and cytopathological analysis was suggestive of SPPT. She underwent conventional cephalic duodenopancreatectomy. She presented septic postoperative complications, with a favorable outcome after medical and surgical therapy. she remains asymptomatic, after 6 months follow-up. Conclusion: Solid pseudo papillary pancreatic tumor is a rare exocrine low-grade neoplasm. EUS is a sensitive tool in the diagnosis of SPPT, identifying and characterizing the pathologic lesions, and allowing EUS-FNA with cytomorphological recognition, making it an invaluable tool for establishing diagnosis, helping clinical management and surgical planning.
Solid pseudopapillary neoplasm, a rare pancreatic tumor-case report
International Surgery Journal
The uncommon cystic exocrine pancreatic tumor known as solid pseudopapillary epithelial neoplasm (SPEN) most frequently affects young females. We provide a case study of a 17-year-old female who experienced intermittent vomiting and epigastric pain. Her laboratory results were within normal ranges, and a clinical abdominal exam revealed pain in the region of epigastrium. A 40×3×31 mm iso-hyperdense minimally enhancing solid mass with well-defined borders was detected on her CECT scan. Nothing calcified. neither localized lymphadenopathy nor fat stranding. It was just next to the splenic vein, which was completely opaque. Her histopathology revealed a solid pseudopapillary pancreatic tumor after she underwent a spleen preserving distal pancreatectomy. Beta-catenin and vimentin IHC assays were significantly positive, confirming the diagnosis and she was on a regular follow-up. As of now, the patient is asymptomatic and has not experienced a recurrence. In contrast to other forms of pa...