EFFECT OF FRESH RAW QUAIL EGGS ON THE LIPID PROFILE AND BLOOD SUGAR LEVEL OF DIABETES-INDUCED ALBINO RATS -A REVIEW (original) (raw)
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Metabolic effects of quail eggs in diabetes-induced rats: comparison with chicken eggs
Food & Nutrition Research, 2016
Background: Quail eggs as a food item have recently been introduced into the diet of some Cameroonians. These eggs are being sold in local markets, but with many unfounded health claims. One claim is that quail eggs can reduce blood glucose levels in diabetics. It was therefore necessary to evaluate the effect of consuming quail eggs on blood glucose levels, lipid profiles, and oxidative stress parameters in diabetes-induced rats. Methods: Twenty Wistar rats weighing, on average, 250 g were divided into four groups of five rats each. Group 1 consisted of rats with normal blood glucose, and the other three groups (2, 3, and 4) consisted of diabetes-induced rats achieved by intravenous injection of streptozotocin. During 16 days, rats in groups 1 and 2 received distilled water; and rats in groups 3 and 4 received quail and chicken eggs, respectively, with gastroesophageal probe at a dose of 1 mL/200 g body weight. Fasting blood glucose levels were determined in all the groups on the 1st, 7th, 14th, and 17th days after induction of diabetes. On the 17th day, the fasting rats were sacrificed, and blood and liver samples were collected for biochemical analyses. Results: In 17 days, the consumption of quail and chicken eggs had no effect on blood glucose levels of diabetic rats. Total cholesterol levels were higher in groups 3 (75.59 mg/dL) and 4 (59.41 mg/dL) compared to group 2 (55.67 mg/dl), although these differences were not significant (all p !0.05). Triglyceride levels were significantly higher (p B 0.05) in groups 3 (106.52 mg/dL) and 4 (109.65 mg/dL) compared to group 2 (65.82 mg/dL). Quail eggs had no effect on oxidative stress parameters (malondialdehyde, hydroperoxides, and catalase). Conclusions: The consumption of quail eggs by diabetic rats at the tested dose had no effect on blood glucose level and oxidative stress parameters and may have a negative effect on lipid profile.
Biomedical Research, 2018
Quail eggs have been found useful in folk medicine in treatment of some diseases, but its consumption is not as common as chicken eggs amongst humans. This study was aimed at determining the dietary effects of quail eggs on blood sugar and lipid profile of alloxan induced diabetic rats. Quail egg samples were analysed for its various nutritional compositions using the Association of Official Analytic Chemistry (AOAC) methods. Quail eggs were administered to thirty six (36) alloxan induced diabetic rats, which were divided into nine (9) different groups of four (4) rats each per group at varied doses for a duration of seven (7), fourteen (14) and twenty one (21) days. Their blood sugar and lipid profile were determined using standard methods. Proximate analysis showed that quail egg could be a good source of protein, lipid and has high moisture content while it has minimal ash and carbohydrate contents. Rats treated with two (2) raw quail eggs showed the highest blood glucose lowering capacity and weight gain when compared with the insulin treated rats. Evaluation of the blood glucose at intervals (d 7, d 14, and d 21) showed that quail eggs could serve for mid-term and long term treatment of diabetes, but did not have any significant effects on the serum lipid profile of diabetic rats. It could be concluded that intake of quail egg diets either alone or as part of a therapeutic regime, could have beneficial effect in the prevention and management of diabetes mellitus.
Evaluation of the Possible Hypolipidemic Properties of Quail Egg on Alloxan-Induced Diabetic Rats
This study evaluated the pancreatic histomorphometry and possible hypolipidemic effects of graded concentrations of quail egg administration on alloxan-induced diabetic rats. Thirty adult male albino rats were assigned to 5 groups of 6 rats per group. Diabetes was induced in the rats of groups 2-5 by single intraperitoneal injection of alloxan monohydrate at the dose of 160 mg/kg. Group 1 rats were not injected with alloxan monohydrate. Rats with fasting blood glucose levels above 126 mg/dl were considered diabetic. Upon establishment of diabetes, rats in groups 2-4 were treated with 30, 15 and 7.5 mg/ml of quail egg solution respectively. Rats in groups 1 and 5 were administered with 10 ml/kg distilled water. At the end of the 21 days treatment, blood samples were collected for lipid profile analyses. The rats were euthanized using chloroform anaesthesia and the pancreases were then collected for histomorphometric assessment. Results of the study revealed that rats treated with 30 mg/ml of quail egg solution showed significant (P<0.05) reductions in the serum levels of total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein when compared with the negative control group while high density lipoprotein was not significantly increased compared to the negative control. The pancreas of diabetic untreated rats showed immense cytoplasmic vacuolation of the islet cells while the groups treated with quail egg solution especially those treated at the 30 mg/ml showed mild degeneration of the islet cells. In conclusion, administration of quail egg solution to alloxanized rats demonstrated hypolipidemia and ameliorated lesions in the pancreas.
Journal of Advances in Medical and Pharmaceutical Sciences, 2016
This study evaluated the effects of different concentrations of quail egg solution on glycemia and some antioxidant markers in alloxan-induced diabetic rats. Thirty adult male albino rats were assigned to 5 groups of 6 rats per group. Groups 2, 3, 4 and 5 were made diabetic by single intraperitoneal injection of 160 mg/kg alloxan monohydrate. Upon establishment of diabetes (fasting blood glucose levels above 126 mg/dl), the rats in groups 2, 3 and 4 were respectively administered with 30, 15 and 7.5 mg/ml orally daily for 21 days. Groups 1 and 5 were administered with distillled water. Fasting blood glucose (FBG) levels of the rats were assessed 1 h, 6 h, 24 h and 21 days post treatment. On the 21 st day, blood samples were collected for malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (RSH) assays. Results indicate that administration of quail egg solution at the concentration of 30 mg/ml to the diabetic rats significantly (p< 0.05) reduced the FBG from 343.80 to 87.20 mg/dl on day 21 post treatment. There was significant (p< 0.05) reduction in the mean MDA values of the 30 mg/ml-treated groups compared to Original Research Article
Comparative Clinical Pathology, 2015
This study was designed to investigate the effect of quail egg on the haematological parameters and the histopathology changes of the pancreas and liver of alloxan-induced diabetic Wistar albino male rats. Thirty albino rats with a mean weight of 160±15 g were randomly selected into five groups, each with six rats. Groups 2, 3, 4 and 5 were induced with diabetes by intraperitoneal injection of alloxan at a dose of 160 mg/kg. Upon confirmation of diabetes (fasting blood sugar (FBS) >126 mg/dl), rats in groups 2, 3 and 4 were orally administered with 30, 15 and 7.5 mg/ml of quail egg. Group 1 and 5 rats were administered with distilled water to serve as positive and negative controls, respectively. The treatment lasted for 21 days, and blood samples for haematology [red blood cell (RBC), white blood cell (WBC), haemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC)] analyses were collected on days 7, 14 and 21. On the 21st day, two rats per group were humanely sacrificed and the vital organs (pancreas and liver) were collected for histopathology. Haematologic results obtained showed marked reduction (p<0.05) in RBC count, PCV, Hb and MCHC, a significant increase (p<0.05) in MCV and no significant difference (p>0.05) in the WBC of the induced animals when compared with the positive control. However, on administration of the quail egg at 30 mg/ml, there was a significant increase (p<0.05) in the RBC on days 7 and 14; PCV on days 7, 14 and 21; and Hb on days 7, 14 and 21 when compared with the negative control. There was also a significant decrease (p<0.05) in the MCHC at a concentration of 7.5 mg/ml on day 21 when compared to the negative control, while MCV showed no significant difference (p>0.05). The histopathology of the pancreas of the untreated induced rats showed immense cytoplasmic vacuolation, while those treated with 30 mg/ml of quail egg showed mild cytoplasmic vacuolation. The liver histopathology of the untreated induced rats showed mononuclear leucocyte and multifocal areas of coagulative necrosis, while the rats treated with 30 mg/ml of quail egg showed no visible lesion. It can be concluded that quail egg possesses hepatoprotective property and also can improve haematologic profile of diabetic rats.
Effect of Quail Egg Administration on Some Liver Function Related Parameters
Notulae Scientia Biologicae, 2017
There are a lot of testimonies on the therapeutic efficacies of quail egg on diabetics and on liver disorders. This study investigated synthetic and conjugatory states of the liver in diabetic rats administered varying concentrations of quail egg solution. Thirty (30) adult male albino Wistar rats were assigned to 5 groups of 6 rats each. Groups 2-5 of rats were injected with alloxan monohydrate intraperitoneally at the dose of 160 mg/kg, while rats in group 1 served as normal control. Upon establishment of fasting blood glucose level above 126 mg/dl, the rats in groups 2-4 were administered 30, 15 and 7.5 mg/ml of quail egg solution respectively for 7 days. Rats in groups 1 and 5 received distilled water (10 ml/kg) each. All treatments were through the oral route. At the end of the 7 days duration of the study, blood samples for serum protein and bilirubin assays were collected. Results indicated that the quail egg administration to alloxanized rats did not alter total serum protei...
Notulae Scientia Biologicae
The present study evaluated the effect of whole egg consumption on the liver, testes, cauda epididymal sperm reserve and lipid profile of male rats. These evaluations were carried out on adult twenty (20) male albino rats, which were randomly selected into four groups of 5 rats each, designated groups A, B, C and D. Group A was the control group and received only equivalent volume of distilled water, while groups B, C and D received 0.25mg/kg, 0.5mg/kg; and 1.0mg/kg body weight of the quail egg respectively. Standard procedures were carried out in the tissue processing, cauda epididymal sperm reserve and in lipid profile determinations. On days 35 and 49, the mean serum total cholesterol value of group D was significantly lower than that of the control group. On day 35, the mean serum low density lipoprotein and high density lipoprotein (LDL and HDL cholesterol) values of all the treatment groups were significantly lower and higher than that of the control group, respectively. Howev...
Biochemistry Research International, 2016
Cold and immobilization stressors can generate oxidative stress as well as skeletal muscle fatigue. Free radicals cause oxidative degradation of lipids, proteins, nucleic acids, and carbohydrates molecules, thereby compromising cell integrity and function. Quail egg had been described as being very functional biochemically, due to the essential biomolecules it contains in very regulated quantity. This study was aimed for evaluating the dietary effect of the egg on lipid profile parameters on selected tissues. The antilipidemic properties of the egg yolk and albumen and poultry (layers) feed were determined in selected tissues in male albino rats assaulted with cold immobilization stress induced on them at 4°C for 2 hours, while diazepam was used as standard antistress drug. Antilipidemic activities were evaluated by lipid profile modulation (HDL, LDL, TRIG., and T-CHOL.). Quantitative and qualitative analyses of fatty acids profile of the yolk hexane-extract were determined by Gas C...
Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021), 2022
Induction by high-fat diet (HFD) is frequently performed for research on hypercholesterolemia in experimental animals. In general, HFD is obtained by combining various components, but only few studies have investigated the potential of each component to induce hypercholesterolemia in experimental animals. This study aimed to identify the potential of a number of HFD components found on a day-today basis in society for induction of hypercholesterolemia in animal models. The research involved a posttest only group design conducted on 30 Rattus norvegicus rats for 28 days. In addition to receiving standard ad-libitum feed, the rats were given appropriate treatment according to the group, each at a dose of 1ml/100gBW for P1 = distilled water, P2 = chicken egg yolk, P3 = quail egg yolk, P4 = duck egg yolk, P5 = liquid butter, and P6 = liquid margarine. The lipid profile (total cholesterol, LDL, HDL, triglycerides) was examined at the end of the study. The obtained blood serum was examined using a spectrophotometry to yield the lipid profile data. The atherogenic index (AI) was measured by dividing LDL by HDL. The data were analyzed using a one-way ANOVA. This study showed that induction by duck egg yolk for 28 days resulted in the highest levels of total cholesterol, LDL, HDL, and AI (P4; total cholesterol = 85.00 ± 22.86, LDL = 23.20 ± 9.05, HDL = 37.16 ± 12.21, AI = 0.63 ± 0.12). The induction by liquid margarine was able to result in the highest increase in the triglyceride level compared to the healthy group and other induction of hypercholesterolemia, but there was no difference in the levels of total cholesterol (p = 0.362), LDL (p = 0.112), HDL (p = 0.631), triglycerides (p = 0.427), and AI (0.094). This study shows that duck egg yolk has the potential to be used in induction of hypercholesterolemia in experimental animals..
Effect of Modified-Hen-Egg-Yolk-Lipid-Composition Diet on Plasma Lipids in Rats
Macedonian veterinary review, 2023
This study aimed to investigate the effects of dietary supplementation with modified-hen-egg-yolk on plasma lipids and lipoprotein profiles in rats. During the four-week-experiment, 64 Wistar rats were divided into four groups of 16 (eight of both sexes), and fed commercial rat food (group C); food containing 70% commercial rat mixture and 30% freshly cooked egg yolk originating from laying hen eggs fed with 3% fish oil (group F); 3% palm olein (group P), or 3% lard (group L). The cooked egg yolk in the rat diet affected the concentrations of plasma total and LDL-cholesterol in males of the P and L groups. Cholesterol and total fat in the diet did not have a hypercholesterolemic effect on their own, but when in combination with fatty acid composition, they could contribute to an increase in plasma total and LDL cholesterol concentrations in rats. HDL-cholesterol was the most resilient plasma lipoprotein of rats to dietary treatments in our experiment. Compared to the control group, the addition of hen egg yolk to the rat diet regardless of its quality, adversely affected the values of HDL-C/TC and HDL-C/LDL-C in both males and females.