Variants in the nicotinic receptors alter the risk for nicotine dependence (original) (raw)
2008, The American journal …
ObjectiveA recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the α5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study is to replicate these findings in an independent dataset and more thoroughly investigate the role of genetic variation in the cluster of physically linked nicotinic receptors, CHRNA5-CHRNA3-CHRNB4, and the risk of smoking.MethodsIndividuals from 219 European American families (N=2,284) were genotyped across this gene cluster to test the genetic association with smoking. The frequency of the amino acid variant (rs16969968) was studied in 995 individuals from diverse ethnic populations. In vitro studies were performed to directly test whether the amino acid variant in the CHRNA5 influenced receptor function.ResultsA genetic variant marking an amino acid change showed association with the smoking phenotype (p=0.007)....
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.