Biomimetics Integrated Nanoscience in Dental Tissue Regeneration : A Review (original) (raw)
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Nanobiotechnology in Regenerative Dental Medicine
Nanomaterials in Dental Medicine- SpringerLink Nature, 2023
Nanotechnology harnesses the phenomenal atomic and molecular behaviour of materials at a nanoscale size (1–100 nm) to provide solutions to a vast array of scientific applications. Although nanomaterials are commonly classified as carbon-based, organic-based, inorganic-based and composite-based, there are several other classification systems (based on chemical composition, shape, origin, dimensionality and crystallinity). The use of nanobiomaterials finds crucial use in all domains of regenerative tissue engineering, including cellular therapies (mostly stem cells), hybrid biomimetic organic–inorganic materials, as well as artificial/purely inorganic prosthetic devices. Although the field of regenerative nanomedicine has gained significant popularity, regenerative nanodentistry and its potential manifold applications in the era of precision medicine still needs to be promoted, to bring much desired advancement to the field of individualized/precision dentistry. Dental tissues like the rest of human tissues are made up of molecules, and the application of nanotechnology to molecular science will foster remarkable progress in regenerative nano-dental science problem management, leveraging molecular knowledge to improve and maintain “molecular-scale” dental health. Despite the invaluable promise of regenerative nanodentistry, ethicolegal, regulatory, privacy, metaphysical, equity, safety, social security and public acceptance issues, viz-a-viz its use, persists. Hence, this review focuses on discussing the current and potential applications of note in the field of nanobiotechnology in regenerative dental medicine.
Advanced Nanomaterials: Promises for Improved Dental Tissue Regeneration
Nanotechnology in Endodontics, 2015
Nanotechnology is emerging as an interdisciplinary fi eld that is undergoing rapid development and has become a powerful tool for various biomedical applications such as tissue regeneration, drug delivery, biosensors, gene transfection, and imaging. Nanomaterial-based design is able to mimic some of the mechanical and structural properties of native tissue and can promote biointegration. Ceramic-, metal-, and carbon-based nanoparticles possess unique physical, chemical, and biological characteristics due to the high surface-to-volume ratio. A range of synthetic nanoparticles such as hydroxyapatite, bioglass, titanium, zirconia, and silver nanoparticles are proposed for dental restoration due to their unique bioactive characteristic. This review focuses on the most recent development in the fi eld of nanomaterials with emphasis on dental tissue engineering that provides an inspiration for the development of such advanced biomaterials. In particular, we discuss synthesis and fabrication of bioactive nanomaterials, examine their current limitations, and conclude with future directions in designing more advanced nanomaterials.
Nanomaterials for Tissue Engineering In Dentistry
Nanomaterials, 2016
The tissue engineering (TE) of dental oral tissue is facing significant changes in clinical treatments in dentistry. TE is based on a stem cell, signaling molecule, and scaffold triad that must be known and calibrated with attention to specific sectors in dentistry. This review article shows a summary of micro-and nanomorphological characteristics of dental tissues, of stem cells available in the oral region, of signaling molecules usable in TE, and of scaffolds available to guide partial or total reconstruction of hard, soft, periodontal, and bone tissues. Some scaffoldless techniques used in TE are also presented. Then actual and future roles of nanotechnologies about TE in dentistry are presented.
Progress in Polymer Science, 2013
Tissue engineering approach focuses on the regeneration of deficient or damaged tissues of the body. Regeneration of dental tissues is considered as a promising therapeutic approach in dental tissue engineering. Engineering the environment for developing tissues comprises of biomaterials, growth factors, stem cells and regulation of physiological conditions in a spatial and temporal manner. To enhance the structural stability and bioactivity of polymers, a wide variety of nanomaterials are being utilized in dental regenerative medicine. Nanostructured biopolymers in the form of scaffolds, hydrogels, nanofibers, dendrimers, films, etc. and nanostructured bioceramics such as hydroxyapatite, bioactive glass ceramic/bioglass, etc. in the form of nanoparticles, nanocrystals, nanorods, paste, etc. are being exploited in the simultaneous regeneration of hard and soft tissues of the human body. In the dental area, these different forms closely mimic the natural constituents and framework of the dental tissues, namely enamel, dentin and periodontium. Overall this review essentially focuses on the role of polymeric and ceramic nanomaterials in the area of dental tissue engineering, highlighting their specific applications in enamel, dentin and periodontal regeneration.
Nanotechnology in Periodontal Regeneration: A Review
Indian Journal of Forensic Medicine & Toxicology, 2020
Periodontitis involves destruction of the periodontal ligament and supporting structures. It ranges from a simple inflammation of gums to major damage resulting in loss of bone. Multiple conditions like trauma, periodontal disease, reconstructive surgery, ageing, osteoporosis and neoplastic pathology, have a common characteristic feature being loss of bone and tissue. The regenerative procedures that are currently practiced aim to regenerate the lost tissue via means of grafting, placement of membranes and many more, but have been accompanied with a set of limitations and major disadvantage being graft rejection. Periodontal regeneration still endures to be a partially unsolved algorithm. In dentistry, a new arena of development is being exploited to set a new approach for regeneration that is Nanotechnology. This branch involves tissue engineering which aims to regenerate the lost tissues via manufacturing scaffolds which transport signaling cells and molecules. These scaffolds possess magnificent physical as well as chemical properties and biomimetic features that act as a substitute of the highest standard offering innumerable benefits for promoting cell growth and tissue regeneration via tissue engineering.Nanomaterials because of their refined physiochemical characteristics and biomimetic attributes serve as a scope worthy substitute that offers several advancements for stimulation of cell growth and tissue regeneration. This review provides an insight to basic information about nanotechnology, the various nano particles having application in periodontal regeneration, the advanced regenerative procedures fabricated on the principles of nanotechnology, their applications, the clinical studies highlighting the achievements so far, supremacy over the conventional method and limitations.
Nanobio-technology is a term that refers to the junction of Nanotechnology and Biology. There has been considerable research interest in study of functionalized nanostructures in nanobio-medical applications in recent years. There are extensive applications of nanobiotechnology in biomedical engineering such as implant and tissue engineering, diagnosis and therapy. The unique size-dependent properties of nanobio-materials make these materials superior and essential in many areas of tissue engineering. This brief mini-review tries to summarize the most recent advances in the field of applied nanobio-technology, in particular their application in dental tissue engineering.
Explore the most recent developments and upcoming outlooks in the field of dental nanomaterials
Background The rapid evolution of nanotechnology has fundamentally transformed both medical and dental fields. By harnessing nanomaterials, researchers have unlocked the ability to replicate natural tissue structures and properties, significantly enhancing integration processes. Notably, nanostructures have emerged as pivotal elements in oral medicine, particularly in combating dental caries and enhancing outcomes in dental implants and maxillofacial surgeries. Main body of the abstract Nanostructures play multifaceted roles in oral health, promoting osseointegration and expediting healing processes in dental procedures. The impact of these materials extends to improving the adhesive strength and overall properties of dental composites. This review critically evaluates the influence of nanointerfaces on the longevity of dental restorations, exploring innovative nanotechnological interventions aimed at augmenting restoration durability. Furthermore, recent strides in nanodentistry are discussed, highlighting breakthroughs in oral health diagnostics, preventative strategies, and treatment modalities essential for achieving and sustaining optimal oral health. Short conclusion Incorporating nanotechnology into dental practice presents exciting prospects for advancing oral healthcare. From enhancing restoration durability to revolutionizing diagnostics and treatments, nanotechnology offers transformative solutions that hold significant promise for the future of oral health management.
Role of nanotechnology in regeneration of pulpo-dentinal complex
International journal of health sciences
Nanotechnology has completely revolutionized the field of Dentistry with enormous applications and opened up ample research opportunities in the field. Most research activities in Endodontics are performed in pursuit of regeneration of pulpo-dentinal complex. As in other fields, nanotechnology has ameliorated regenerative Endodontics and has brought about considerable promise to the field. Application of nanotechnology could even increase thesuccess rate of regeneration owing to biomimetic modifications in stem cells and scaffolds, which may soon be translated to clinical practice. This review highlights the important research activities in regeneration of dental pulp in collaboration with nanotechnology.