Alph 1 microglobulin protein as a reliable marker for early diagnosis of renal tubular injury (original) (raw)

Abstract

Twenty five patients with renal tubular damage and ten age-matched healthy control subjects were included in this study. Urinary α1 microglobulin (ά 1M) and ß2 microglobulin (ß2M) were measured and the results were expressed as a ratio to urinary creatinine to avoid variation in urine flow rate. There was a highly significant increase of urinary ά1M/ creatinine ratio and ß2M/ creatinine ratio in patients as compared to healthy control groups. Also, there was a highly significant correlation between ά1M and ß2M (r=0.8, P<0.001). Stability studies revealed that, ά1M was stable in acidic and alkaline urine (P>0.05). On the other hand, ß2M showed marked deterioration in acidic urine (P<0.001). Analysis of receiver operating characteristics (ROC) curve revealed that the diagnostic performance of ά1M was superior to ß2M. The best cut off level of ά1M (13mg/g creatinine) had a diagnostic sensitivity of 95%, specificity 97% and efficacy 96.7%. As regard to ß2M, the best cut off lev...

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