Identification of lignans and related compounds in Anthriscus sylvestris by LC–ESI-MS/MS and LC-SPE–NMR (original) (raw)

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The study investigates the potential of Anthriscus sylvestris as an alternative source of podophyllotoxin, a critical compound used in anticancer drugs. By employing LC–ESI-MS/MS and LC-SPE–NMR techniques, fourteen compounds were identified in the root extracts of A. sylvestris, including deoxypodophyllotoxin as the primary lignan. The research includes an exploration of the metabolite concentration variations during different developmental stages of the plant, as well as successful genetic transformation of A. sylvestris to potentially increase podophyllotoxin production, suggesting avenues for enhanced pharmaceutical applications.

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