Physiological factors influencing radioantibody uptake: A study of four human colonic carcinomas (original) (raw)

1992, International Journal of Cancer

We evaluated the accretion of '3'l-labeled NP-4 anticarcinoembryonic antigen (CEA) into 4 size-matched human colonic carcinomas grown S.C. in nude mice. Antibody uptake for LS I74T and GW-39 tumors was relatively high (I 9 to 23% ID/g on day 3), whereas moderate uptake was seen in the Moser tumor (7.5% on day 3) and low uptake was detected in the GS-2 tumor (I .8% on day 3). Blood clearance of radioanti-'To whom correspondence and reprint requests should be addressed. Abbreviufions: BF, blood flow rate; CEA, carcinoembryonic antigen; ICH, immunocytochemistry; IDig, injected dose per gram; MAb. monoclonal antibody; MAR, microautoradiography; VP, vascular permeability; W, vascular volume.

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