melatonin predicts mood improvement (original) (raw)

This research investigates the relationship between melatonin levels and mood improvement post-administration of clomipramine, an antidepressant. In a study with healthy participants, 32 subjects were monitored for urinary excretion of 6-sulfatoxymelatonin (aMT6s) before treatment and on the first and twenty-first days after treatment. Results indicated a significant increase in aMT6s in responders on day one, suggesting that enhanced melatonin output may predict emotional improvement, while no significant changes were observed in non-responders. The findings imply a complex interplay between norepinephrine uptake, melatonin secretion, and mood enhancement.