Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors (original) (raw)
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Bone Mineral Density and Trabecular Bone Score in Ukrainian Men with Obesity
Journal of Clinical Densitometry, 2018
Osteoporosis and obesity are widespread diseases in people over 50 years associated with changes in structure and body composition. Нigher body mass index (BMI) values are associated with greater bone mineral density (BMD). However, trabecular bone score (TBS) indirectly explores bone quality, independently of BMD. The aim of our study was to evaluate the relationship between the BMD and TBS parameters in Ukrainian men suffering from obesity. We examined 396 men aged 40-89 years. Depending on their BMI all the subjects were divided into two groups: Group I-patients with obesity whose BMI was ≥ 30 kg/m 2 (n=129) and Group II-patients without obesity and BMI of < 30 kg/m 2 (n=267). The BMD of total body, lumbar spine L 1-L 4 , femoral neck and forearm were measured by DXA (Prodigy, GEHC Lunar, Madison, WI, USA). The TBS of L 1-L 4 was assessed by means of TBS iNsight® software installed on DXA machine (product of Med-Imaps, Pessac, France). In general, obese men had a significantly higher BMD of lumbar spine L 1-L 4 , femoral neck, total body and ultradistal forearm (p < 0.001) in comparison with men without obesity. The TBS of L 1-L 4 was significantly lower in obese men compared to non-obese ones (p < 0.001). BMD of lumbar spine L 1-L 4 , femoral neck and total body significantly differ in men aged 40-49, 50-59, 60-69, and 80-89 years (p < 0.05). At the same time, in men aged 70-79 years, BMD of lumbar spine L 1-L 4 (p=0.46), femoral neck (p=0.18), total body (p=0.21), ultra-distal forearm (p=0.13), and TBS (p=0.07) did not significantly differ. A significant positive correlation between the fat mass and the BMD at different sites was observed. However, the correlation between the fat mass and TBS of L 1-L 4 was also significant, though negative.
Trabecular Bone Score in Overweight and Normal-Weight Young Women
2018
The aim of this study was to compare Trabecular Bone Score (TBS) in overweight and normal-weight young women. This study included 14 overweight (BMI > 25 kg/m2) and 42 normal-weight (BMI < 25 kg/m2) young Lebanese women whose ages range from 18 to 32 years. Body composition, Bone Mineral Content (BMC), Bone Mineral Density (BMD), and lumbar spine (L1–L4) TBS were assessed by dual-energy X-ray asborptiometry (DXA). The DXA measurements were completed for the whole body (WB), the lumbar spine (L1–L4), the total hip (TH) and the femoral neck (FN). Physical activity, daily calcium intake, daily protein intake and sleep quality index were evaluated using validated questionnaires. Maximal oxygen consumption (VO2 max in l/mn) was measured whilst exercising on a bicycle ergometer using a specialized device. Weight, height, BMI, lean mass, fat mass, WB BMC, WB BMD, TH BMD and FN BMD were significantly higher in overweight women compared to normal-weight women. Trabecular Bone Score (TB...
Trabecular bone score in healthy ageing
Journal of Orthopaedic Translation, 2014
The main aim of this work was to report on trabecular bone score (TBS) by dual-energy X-ray absorptiometry (DXA) of healthy Italian subjects to be used as a reference standard for future study in clinical and research settings. The secondary aim was to investigate the link between TBS and conventional parameters of bone and body composition by DXA. Methods: 250 individuals of 5 age bands (spanning from 18 to 70 years of age, equally distributed for both age and sex) were prospectively recruited. A lumbar spine (LS) DXA scan (Lunar iDXA™; GE Healthcare, Madison, WI) was acquired for each subject and then analysed with the latest version of TBS iNsight v. 2.1 (Med-Imaps, Pessac, France) software. LS bone mineral density (LS BMD), Z-score, T-score and TBS values were collected. Pearson's test was used to investigate the correlations between TBS and LS BMD and the influence of age, body mass index (BMI) and body composition on these parameters. Results: A significant decrease of TBS and LS BMD was observed with ageing in both males (TBS mean values from 1.486 to 1.374; LS BMD mean values from 1.219 to 1.187) and females (TBS mean values from 1.464 to 1.306; LS BMD mean values from 1.154 to 1.116). No statistically significant difference was achieved among males and females of the same age group for both TBS and LS BMD, with the exception of the fifth age group. A significant correlation was found between LS BMD and TBS values in both sexes (r 5 0.555-0.655, p , 0.0001). BMI influenced LS BMD but not TBS. TBS values were inversely correlated with some fat mass parameters, in particular with visceral adipose tissue (in males: r 5 20.332, p , 0.001; in females: r 5 20.348, p , 0.0001). No significant correlation was found between TBS and total lean mass, opposite to LS BMD (in males: r 5 0.418; p , 0.0001; in females: r 5 20.235; p , 0.001). Conclusion: This report is an attempt to start building a database for healthy Italian people providing age-and sexspecific reference curves for TBS. This could help clinicians to improve patient management in the detection of impaired bone mineral status and to monitor bone changes. Advances in knowledge: The study reports TBS values of a selectively enrolled Italian healthy population, ranging from younger to older ages and including males as a reference standard. Moreover, links between body composition and TBS are explored.
CO06. Fat mass, insulin resistance and vitamin D impact on trabecular bone score in men
Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, 2016
The lean and fat masses, bone mineral density (BMD) were measured by the DXA method (Prodigy, GEHC Lunar, Madison, WI, USA). Appendicular skeletal mass (ASM) was measured at all the four limbs with DXA. We've also calculated the appendicular skeletal mass index (ASMI) according to the formula: ASM/height (kg/m 2). Results: We observed a significant decrease of ASM with age (20-29 yrs-16.5 ± 0.4 kg, 30-39 yrs-16.4 ± 0.3 kg, 40-49 yrs-17.0 ± 0.5 kg, 50-59 yrs-16.9 ± 0.3 kg; 60-69 yrs-16.5 ± 0.2; 70-79 yrs-15.8 ± 0.3; 80-87 yrs-15.3 ± 0.3; F = 2.7; p = 0.01). The ASMI values corresponding to a cutoff of low muscle mass by the definitions used were as follows: < 5.5 kg/m 2 (European guideline), < 5.7 kg/m 2 (< 20 th percentile of sex specific population), < 4.8 kg/m 2 (two SD below the mean of young Ukrainian females aged 20-39 yrs). The prevalence of low muscle mass in women aged 65 yrs and older based on the above three criteria was 12%, 16% and 1.7%, respectively. ASM was positively correlated with total fat mass (r = 0.20, p = 0.0006) and BMD at all sites (BMD of spine (r = 0.22, p = 0.0002), BMD of femoral neck (r = 0.29, p < 0.0001)). Conclusions: The cutoff value of ASMI (< 4.8 kg/m 2) was lower in our study compared with Rosetta Study (< 5.5 kg/m 2) and similar to Health ABC study (< 5.67 kg/m 2).
Immunopathologia Persa, 2022
Introduction: Bone mineral density (BMD) and trabecular bone score (TBS) are recognized as two indexes for diagnosis of osteoporosis. Objectives: The present study assesses the TBS performance as an alternative test for BMD. Patients and Methods: A retrospective descriptive study conducted on 2,106 patients were referred to two central hospitals; Resalat and Loghman in Tehran, Iran. Necessary data have been collected for the analysis process, including age, gender, body mass index, and L1-L4 TBS. Results: Four-hundred eligible patients were considered for our analysis process. Among these patients, about 13.8 and 86.3% were men and women with mean ages of 54.04 ± 10.92 and 53.83 ± 10.16 years, respectively (P = 0.88). Our study showed a statistically significant difference between the mean TBS of all regions in patients (P = 0.001), while this value was dependent on the gender and age of patients. The mean TBS of all regions in women younger than 50 years was significantly higher than those older than 50 years (P < 0.001). Moreover, a statistically significant difference was observed between the means of the best regional TBS in all study groups (P < 0.001). This study showed the lumbar spine TBS had a negative correlation with body mass index in women, while this correlation was not significant in men. Conclusion: Trabecular bone score can be conducted as a complementary index along with BMD, it can be employed independently as an appropriate indicator for osteoporosis.
Bone Variables in Active Overweight/Obese Men and Sedentary Overweight/Obese Men
Journal of Clinical Densitometry, 2017
The aim of this study was to compare bone variables in active overweight/obese men and sedentary overweight/ obese men. Thirty-seven active overweight/obese men and 45 sedentary overweight/obese men participated in this study. Weight and height were measured, and body mass index was calculated. Body composition and bone variables (bone mineral content [BMC], bone mineral density [BMD], geometric indices of hip bone strength, and trabecular bone score) were measured by DXA. Physical activity level, daily calcium intake, daily protein intake, and sleep duration were measured by validated questionnaires. Maximum oxygen consumption (VO2 max) was determined by direct measurement while exercising on a medical treadmill. Onerepetition-maximum half-squat of the lower limbs was measured using a validated protocol. Body weight and body mass index were higher in sedentary overweight/obese men than in active overweight/obese men. In the whole population (n = 82), VO2 max (in liter per minute), lean mass, and one-repetition-maximum halfsquat were positively correlated to BMC, BMD, and geometric indices of hip bone strength (cross-sectional area and section modulus [Z] of the femoral neck [FN]). After adjusting for body weight using a 1-way analysis of covariance, active overweight/obese men displayed higher whole-body BMC, lumbar spine BMD, total hip BMD, FN BMD, FN cross-sectional area, and FN Z values than sedentary overweight/obese men. In conclusion, the current study suggests that physical activity level positively affects bone variables in overweight/ obese men. Optimizing lean mass and muscular strength of the lower limbs can help to prevent osteoporosis in overweight and obese men.
Trabecular Bone Score in Men and Women with Impaired Fasting Glucose and Diabetes
Calcified tissue international, 2017
Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are necessary to more accurately determine fracture risk in individuals with diabetes. Therefore, we aimed to describe the relationship between trabecular bone score (TBS) and normoglycaemia, impaired fasting glucose (IFG) and diabetes and determine whether TBS-adjusted FRAX (Aus) score differed between these groups. This study included 555 men (68.7 ± 12.2 years) and 514 women (62.0 ± 12.0 years), enrolled in the observational Geelong Osteoporosis Study. IFG was considered as fasting plasma glucose (FPG) ≥ 5.5 mmol/L and diabetes as FPG ≥ 7.0 mmol/L, with the use of antihyperglycaemic medication and/or self-report. Using multivariable regression, the relationship between groups and TBS was determined. Men and women (all ages) with diabetes had lower mean TBS compared to those with normoglycaemia, in models adjusted for age, height and weight/waist circumference ...
International Journal of Clinical Practice, 2010
Background: Obese individuals often present comorbidities while they appear protected against the development of osteoporosis. However, few and contradictory data are now available on skeletal modifications in obese patients. The aim of this study was to characterise bone mineral density (BMD) in overweight (BMI > 25 < 29.9) and obese (BMI > 30) patients.Methods: We selected 398 patients (291 women, 107 men, age 44.1 + 14.2 years, BMI 35.8 + 5.9 kg/m2) who underwent clinical examination, blood tests and examination of body composition. Subjects with chronic conditions or taking medications interfering with bone metabolism, hormonal and nutritional status and recent weight loss were excluded.Results: Interestingly, 37% (n = 146) of this population showed a significantly lower than expected lumbar BMD: 33% (n = 98) of women showed a T-score −1.84 ± 0.71, and 45% (n = 48) of men showed a T-score −1.88 ± 0.64. When the population was divided into subgroups based on different BMI, it was noted that overweight (BMI > 25 < 29.9) was neutral or protective for BMD, whereas obesity (BMI > 30) was associated with a low bone mass, compatible with a diagnosis of osteoporosis. No differences were observed in hormones and lipid profiles among subgroups.Conclusions: Our results indicate that a subpopulation of obese patients has a significant low lumbar BMD than expected for age. Thus, a careful characterisation of skeletal metabolism might be useful in all obese individuals to avoid fragility fractures later in life.
Medical Sciences
Obesity has long been considered to have a protective effect on bone, but specific complications in those with morbid obesity are known to have a detrimental impact on bone architecture. We aimed to study the bone microarchitecture (TBS—trabecular bone score) and bone mineral density (BMD) in postmenopausal women with morbid obesity compared to obese and non-obese age-matched women. Eighty-five consecutive postmenopausal women with morbid obesity (body mass index (BMI) ≥ 35 kg/m2) were enrolled and compared to age-matched obese (n = 80) and non-obese postmenopausal controls (n = 85). The BMD and TBS were assessed in all subjects using a Hologic-QDR 4500-W Discovery-A DXA scanner. The mean BMD (gm/cm2) at the femoral neck in women with morbid obesity was found to be significantly lower as compared to the age-matched postmenopausal obese controls (0.723 versus 0.762, p-value = 0.002). The BMD at the lumbar spine and hip showed similar trends but were not statistically significant. The...
Obesity and Bone: A Complex Relationship
International Journal of Molecular Sciences
There is a large literature on the relationship between obesity and bone. What we can conclude from this review is that the increase in body weight causes an increase in BMD, both for a mechanical effect and for the greater amount of estrogens present in the adipose tissue. Nevertheless, despite an apparent strengthening of the bone witnessed by the increased BMD, the risk of fracture is higher. The greater risk of fracture in the obese subject is due to various factors, which are carefully analyzed by the Authors. These factors can be divided into metabolic factors and increased risk of falls. Fractures have an atypical distribution in the obese, with a lower incidence of typical osteoporotic fractures, such as those of hip, spine and wrist, and an increase in fractures of the ankle, upper leg, and humerus. In children, the distribution is different, but it is not the same in obese and normal-weight children. Specifically, the fractures of the lower limb are much more frequent in o...