Synthetic, spectroscopic, magnetic and thermal aspects of drug based metal complexes derived from 1st row transition metal ions (original) (raw)
Related papers
British journal of pharmacology and toxicology, 2011
In Iraq like most third world countries, attempts to discovered a new antibiotic drugs derived from coumarin and its metal complexes moreover develop the branch of applied in organic chemistry. Novel transition metal(II) complexes, [M(L 1) 2 Cl 2 ] and [M(L 2) 2 Cl 2 ], were synthesized from the reaction of MCl 2 .nH 2 O (M = Co, Ni, Cu) with (Z)-1-(1-(1H-indol-3-yl)ethylideneamino)quinolin-2(1H)-one (L 1) or (E)-1-(2hydroxybenzylideneamino)quinolin-2(1H)-one (L 2). The ligands were obtained from coumarin. N-amino quinoline-2-one (2) has been synthesized by the reflux of coumarin (1) with hydrazine hydrate in ethanol for 12 h. The azomethines (L 1 , L 2) were prepared from the corresponding aryl carbonyls. The synthesized compounds were and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, and FT-IR) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for all complexes. The free ligands and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.
IOSR Journal of Applied Chemistry, 2017
The series of Co (II), Ni (II) and Cu(II) metal complexes quinolin-8-yl (1,3-benzoxazol-2ylsulfanyl)acetate (BZ) have been synthesized. All the complexes thoroughly characterized by different physicochemical and spectroscopic techniques (UV-Vis, IR, NMR and ESI-Mass). The powder XRD indicates the crystalline state and morphology of Ni (II) and Cu (II) metal complexes, the thermal stability of the metal complexes as been performed. In the current study, the synthesized compounds were evaluated for their antioxidant activity by using DPPH assay, Cu (II) metal complex exhibited higher antioxidant activity almost close to the standard BHT. In addition, antioxidant activity is correlated with docking interactions of human antioxidant enzyme receptor with the competitive inhibitor DTT (PDB: 3MNG), which showed greater binding interactions with metal complexes. The antimicrobial studies has been carried out against different bacterial and fungal strains and the results showed that metal complexes be more active than the ligand BZ.
Arabian Journal of Chemistry, 2014
Four d-orbital metal complexes with mixed ligands derived from 8-hydroxyquinoline (HQ) and amino acids (AA): L-alanine and methionine have been synthesized through a mild reflux in alkaline solution and characterized by elemental analyses, infrared, electronic transition, and temperature dependant magnetic susceptibility. The IR spectroscopy revealed that iron and copper ions coordinated through carbonyl (C‚O), hydroxyl group (OAH) of the amino acids, N-pyridine ring of hydroxyquinoline. The elemental analysis measurement with other obtained data suggested an octahedral geometry for the iron(III) complexes and tetrahedral geometry for the copper(II) complexes. From the molar magnetic susceptibility measurement, the iron(III) system (S = 5/2) d 5 (non-degenerate 6 A 1 ) with v m T = 0.38 cm 3 Kmol À1 showed an antiferromagnetic while Cu 2+ ions system (S =½) ( 2 T 2g ) has v m T = 4.77 cm 3 Kmol À1 described as paramagnetic behaviour. In vitro antimicrobial investigations of the metal complexes against standard bacteria species gave significant inhibition with, copper complex showing highest inhibitions against Pseudomonas
2020
A Schiff base of 3-[(2-Hydroxy-phenylimino)-methyl]-6-methoxy -quinolin-2- ol was synthesized by a 1:1 molar condensation of 2-Hydroxy-6-methoxy-3-quinolinecarboxaldehyde and 2-aminophenol. The metal (II) complexes were synthesized by refluxing the ethanolic solutions of the Schiff base and the chloride salts of the metals. Melting point, decomposition temperature, solubility, elemental analysis, fourier transform infrared spectroscopy, magnetic susceptibility and molar conductivity measurements were used to characterized the Schiff base and its metal complexes. The Schiff base is yellow and it has a melting point of 251 <sup>O</sup>C. The decomposition temperature of the Cd (II) and Cu (II) complexes were 282 and 270 <sup>O</sup>C respectively. The elemental analysis of the complexes established the formation of 1:1 metal - ligand ratio. The non-electrolytic natures of the complexes were revealed by the molar conductivity values. The behavior of the Schiff b...
Journal of Molecular Structure, 2015
A novel Schiff base ligand N-(4-phenylthiazol-2yl)-2- ((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide (L) obtained by the condensation of N-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR, 1 H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand (L) behaves as tridentate ONS donor and forms the complexes of type [ML(Cl) 2 ] with square pyramidal geometry. The Schiff base ligand (L) and its metal complexes have been screened in vitro for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study the in vitro cytotoxicity properties for the ligand and its metal complexes against Artemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation. complexes, their characterization by various spectroscopic techniques, and their antimicrobial, DNA cleavage, and in vitro cytotoxicity property.
Bioinorganic Chemistry and Applications, 2007
The synthesis and characterization of title complexes of the ligand Quinolino[3,2-b]benzodiazepine (QBD) and Quinolino[3,2b]benzoxazepine (QBO) are reported. The complexes have been characterized by elemental analysis, molar conductance, magnetic studies, IR, 1 H NMR, and UV-visible studies. They have the stoichiometry [ML 2 C1 2 ], where M=Co(II)/Ni(II), L=QBD/QBO, and [MLC1 2 ], where M=Zn(II)/Cd(II), L=QBD/QBO. The antibacterial and antifungal activity of the metal complexes has been investigated. The complexes were found to have higher antimicrobial activity than the parent ligand.
Journal of Molecular Structure, 2021
6-Ethyl-4-hydroxy-2,5-dioxo-5,6-dihydro-2 H-pyrano[3,2-c ]quinoline-3-carboxaldehyde (HL) was synthesized as a ligand and subject to chelate with Cu(II) ion of different anions (AcO-, NO 3-, SO 4 2-ClO 4-, Cland Br-) in presence and absence of auxiliary ligands (L); N,O-donor; or N,N-donor such as 8hydroxyquinoline, 1,10-phenanthroline and 2,2-bipyridyl. The obtained results revealed that the ligand behaves as a neutral/monoanionic bidentate, forming chelates with molar ratio 1:1, (M:L). The metal complexes were fully characterized by analytical and spectral techniques in addition to thermal, magnetic susceptibility and conductivity measurements. The metal complexes displayed square planar and octahedral geometrical arrangements depending on the nature of the anion. The ligand and its complexes were screened for their antimicrobial activity against Gram-positive bacteria which are Staphylococcus aureus and Bacillus subtilis , Gram-negative bacteria which are E. coli and S. typhimurium , yeast (Candida albicans) and fungus (Aspergillus fumigatus). The antitumor activity of the HL ligand and its Cu(II) complexes were examined against Ehrlich Ascites Carcinoma cell line (EAC) from ascetic fluid of the female Swiss albino mice. To explore the most probable structure and the nature of bonding of HL ligand to metal ions; semiemperical (PM3) calculations were achieved in gas phase. All theoretically possible structural data of the free ligand (HL) and its complexes have been correlated with the experimental data to explore the most probable structure.
Chinese Chemical Letters, 2011
Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl} quinolin-8-ol and its metal complexes Abstract A novel 5-((4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)methyl)quinolin-8-ol (HTPSMQol) was synthesized by optimized reaction of 4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)aniline with 5-chloromethyl-8-hydroxy quinoline hydrochloride (CMHQ). Also complexes of HTPSMQol were prepared by using various M (II) metal salts. All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms. The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin. The chemistry of 8HQs has drawn considerable attention due to the biological properties [1] like antiamoebic [2], antimalarial [3], anticancer [4], antileishmanial [5] and antifungal efficiency [6]
Frontiers in Chemistry, 2022
Interest is increasingly focused on the use of transition metal complexes as biochemical, medical, analytical, pharmaceutical, agronomic, anticancer, and antibacterial agents. In this study, three complexes of [Zn(H 2 L)Cl] (1), [Cu(H 2 L)(H 2 O)(NO 3)] (2) and [Ni(H 2 L)(NO 3)].2H 2 O (3) were synthesized from a 2-chloroquinoline-3-carbaldehyde derived ligand [H 3 L = ((E)-2-(((2-((2hydroxyethyl)amino)quinolin-3-yl)methylene)amino)ethanol. The compounds were characterized using physicochemical and spectroscopic methods. The results demonstrate that the free ligand behaves as a tridentate ligand with one oxygen and two nitrogen (ONN) donor atoms in 1:1 metal:ligand ratio. The formation constants of the complexes were found to be (K Zn(II) = 2.3 × 10 6 , K Cu(II) = 2.9 × 10 6 , and K Ni(II) = 3.8 × 10 5). The thermodynamic parameters indicated that the reactions were spontaneous with exothermic nature of metal-ligand interaction energies. Based on the analyses of the experimental (EDX, FTIR, PXRD, MS and TGA) and DFT results, a distorted tetrahedral, a distorted square pyramidal and square planar geometry for Zn(II), Cu(II) and Ni(II) complexes, respectively, were proposed. The B3LYP calculated IR frequencies and TD-B3LYP calculated absorption spectra were found to be in good agreement with the corresponding experimental results. The powder XRD data confirmed that the Zn(II), Cu(II) and Ni(II) complexes have polycrystalline nature with average crystallite sizes of 27.86, 33.54, 37.40 Å, respectively. In vitro antibacterial activity analyses of the complexes were studied with disk diffusion method, in which the complexes showed better activity than the precursor ligand. Particularly the Cu(II) complex showed higher percent activity index (62, 90%), than both Zn(II) (54, 82%) and Ni(II) (41, 68%) complexes against both E. coli and P. aeruginosa, respectively. Using the DPPH assay, the complexes were further assessed for their antioxidant capacities. All metal complexes showed improved antioxidant activity than the free ligand. Zn(II) and Cu(II) complexes, which had IC 50 values of 10.46 and 8.62 μg/ml, respectively, showed the best antioxidant activity. The calculated results of