Tissue Exposures to Free and Glucuronidated Monobutylyphthalate in the Pregnant and Fetal Rat following Exposure to Di-n-butylphthalate: Evaluation with a PBPK Model (original) (raw)
2008, Toxicological Sciences
AI-generated Abstract
This study evaluates tissue exposures of free and glucuronidated monobutylyphthalate (MBP) in pregnant and fetal rats after exposure to di-n-butylphthalate (DBP) through a physiologically based pharmacokinetic (PBPK) modeling approach. It highlights the developmental toxicity of DBP and explores the metabolic pathways of MBP, illustrating how maternal exposure impacts fetal tissue levels. The findings aim to improve understanding of phthalate exposure effects during pregnancy and inform future risk assessments.
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