Development of a new PET biomarker for synaptic function (original) (raw)

Alzheimer's disease is characterized by synaptic failure, prompting the search for a marker indicating synaptic integrity. This study presents [18F]UCB-H, a new PET biomarker derived from SV2A ligands, which has demonstrated high brain uptake and safety in human trials. The findings indicate that this biomarker can improve the classification accuracy of patients with mild cognitive impairment, positioning it as a valuable tool for understanding the early physiopathology of Alzheimer's disease and enhancing diagnostic processes.