Primary bone tumours in Kashmir valley a retrospective histopathological study (original) (raw)
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Pattern of malignant bone tumour in northern areas of Pakistan
JPMA. The Journal of the Pakistan Medical Association, 1994
A review of 280 primary malignant bone tumours diagnosed during 1984-1988 is presented. These constituted 3.14% of all malignant tumours. Male to female ratio was 2.3:1. Majority of these patients presented with rapidly growing mass, pain and deformity. Histologically, osteosarcoma was the most frequent (36.4%) primary malignant tumour. Male to female ratio was 3.31:1. More than 49% of these cases were in their second decade of life. In females the greatest frequency was in 10-15 years and in males 16-20 years age groups. Femur was the most frequent site. Other common malignant bone tumours included chondrosarcoma (22.1%), plasma cell myeloma (15.0%) and Ewings's sarcoma (8.6%). Miscellaneous cases of fibrosarcoma, chrodoma, adamentinoma and ameloblastoma were also seen. This study outlines the frequency, symptomatology and histological pattern of various malignant bone tumours in northern areas of Pakistan.
IP Innovative Publication Pvt. Ltd., 2018
Introduction: The wide spectrum of bone tumours, their diverse origin and the tendency of these tumors to produce overlapping anatomic patterns, make osseous neoplasms a complicated but highly challenging area from the point of view of morphological diagnosis. Objectives: To know the pattern of tumour and tumour-like lesions of bone including their incidence, age, sex and anatomical distribution, histo-morphological features in a tertiary care hospital of South India. Materials and Methods: Biopsies and specimens received at the department of Pathology, Karnataka Institute of Medical Sciences, Hubli from July 2006 to June 2011 (5 year period) are included in the study. Results: A total of 115 cases were included in the study of which 104 (90.4%) were tumors of bone and 11 (9.6%) were tumor-like lesions. Primary bone tumors were seen in 101 (97.1%) cases and secondary tumors were seen in 3 cases (2.9%). Out of all lesions studied, malignant bone tumours were 31 (26.9%), benign bone tumours 71 (61.73%) and tumour like lesions 13 (11.3%). Osteochondroma (50.7%) was most common benign tumor followed by osteoclastoma (40.8%). Osteosarcoma was commonest malignant tumor (58%) followed by Ewing’s sarcoma (16.2%). There were 3 cases of secondary tumors- one of renal cell carcinoma and the other two were adenocarcinomas of unknown primary. Conclusion: This study showed that benign tumours accounted for most of the primary bone tumours. Osteochondroma and osteosarcoma are the most common benign and primary malignant bone tumors, respectively. Keywords: Bone tumours, Giant cell tumour, Histopathology, Osteosarcoma, Osteochondroma.
Incidence and outcome of benign bone tumor experience from tertiary care institute in central India
International Journal of Orthopaedics Sciences
Nonmalignant bone tumors represent a wide variety of different entities but maintain many common features. They usually affect young patients, and most can be diagnosed through imaging exams. Often asymptomatic, they can be discovered incidentally. Due to their similarities, these tumors may be challenging to diagnose and differentiate between each other, thus the need for a complete and clear description of their main characteristics. The advances in in clinical and careful treatment modalities have brought about a major change in the prognosis of such benign harmful bone growths. The aim of this review is to give a picture of the benign bone tumors that clinicians can encounter more frequently in their everyday work and the management for the same. Method: The study is Observational done in Sri Aurobindo Medical College and PG Institute, Indore using REST score to differentiate between benign and malignant tumours on radiograph. Result: The Radiological Assessment Score for Bone Cancers (REST) is an organized revealing and objective technique for the evaluation of radiographs in patients with suspected bone growths. This strategy is a solid and accommodating instrument for clinicians in their outside understanding division to separate a radiograph of a speculated harmless growth from a dangerous bone cancer. Implications: The study will prove useful to clinicians in their outpatient facility where using REST they will be able to differentiate between a speculated harmless growth from a malignant lesion.
A histopathological study of bone lesions in a tertiary care hospital in Kolhapur
International journal of clinical and diagnostic pathology, 2019
Introduction: Bone lesions are relatively uncommon in comparison to other lesions. For the correct diagnosis of bone lesions, charting out treatment plan and estimating prognosis, interpretation of biopsy material proves to be absolutely necessary. This present histopathological study helps us to understand the variety of bone lesions and gives an idea of their relative frequencies, age, sex distributions and site of occurrence. Materials and Methods: This study consists of 83 cases collected over a period of 2 years from October 2017 to October 2019 from patients admitted at Dr. D. Y Patil Hospital, Kolhapur a tertiary care centre with radiologically apparent bone lesions. Hematoxylin and Eosin sections were examined. Detailed microscopic study was done and findings and diagnosis were noted and compared to other studies. Results: Out of the 83 cases studied over the period of 2 years, 41 lesions were non-neoplastic (49.4%), and 42 lesions were neoplastic (50.6%), out of which 33 cases are benign (39.7%) and 9 cases are malignant (10.8%). Males were affected more commonly than females, with a male: female ratio of 1.37:1. Bone lesions were more common in between the age group of 25 to 50 years. Amongst nonneoplastic lesions, Chronic osteomyelitis were the most common (21 cases, 51.3%), followed by avascular necrosis (10 cases, 24.4%).Amongst the benign neoplastic lesions, Giant cell tumor (Osteoclastoma) was the most common (10 cases, 30.3%), Osteochondroma (Exostosis) was the second most common (8 cases, 24.3%).The most common malignant lesion was Chondrosarcoma (3 cases, 33.33%), followed by metastasis to bone (3 cases, 33.33%). Most of the lesions were found in the femur (24 cases, 28.9%). Conclusion: Histopathological study of bone lesions includes variety of non-neoplastic and neoplastic lesions. Although benign and malignant lesions of bone are distinct and well studied, there are some benign lesions that often mimic cancer-causing diagnostic dilemma. Therefore, if diagnosed with clinical, radiological and histopathology, proper diagnosis and treatment can be made.
Clinico-morphological pattern and frequency of bone cancer
JPMA. The Journal of the Pakistan Medical Association, 1999
OBJECTIVE The present study was done to find out the frequency of malignant tumors of bone and to categorize the prevalence of various histological types of osseous malignancies with respect to age, sex and site of origin. SETTING This study included consecutive cases of malignant bone tumors, which were diagnosed in the department of pathology at the Aga Khan University Hospital, Karachi during the period of three years (1995-1997). METHODS These tumors were initially evaluated on H & E stained section from paraffin embedded tissue blocks. Special stains and immunohistochemical analysis was performed whenever required. RESULTS A total of 169 malignant bone tumors were diagnosed during the study period. Metastatic tumors accounted for 28.4% of all malignant tumors of bone. Osteogenic sarcoma (27.2%) was the most frequent primary tumor of bone followed by Ewing's sarcoma (12.4%), Non-Hodgkin's lymphoma (10.6%), Chondrosarcoma (8.3%), Plasma Cell Myeloma (8.3%) and other rare ...
Indian data on bone and soft tissue sarcomas: A summary of published study results
South Asian Journal of Cancer, 2016
Bone sarcomas are rare tumors, approximating 0.2% of all cancers, with osteosarcoma (OGS), chondrosarcoma, and Ewing sarcoma being the most common cancers in this subset. The formation of disease management groups/clinics focused on sarcomas has resulted in better understanding and management of these uncommon tumors. Multiple large-scale retrospective data from Tata Memorial Hospital (TMH) and All India Institute of Medical Sciences have reported outcomes comparable to Western data in the field of OGS and Ewing sarcoma, with interesting prognostic factors identified for further evaluation. Soft tissue sarcomas are a rare heterogeneous group of tumors, more than 50 different tumor entities. The common subtypes identified in India include Ewing sarcoma and synovial sarcoma. Valuable work regarding brachytherapy has been done by radiation oncologists from the TMH, especially in pediatric patients.
Epidemiological data for common bone sarcomas
Asian Pacific journal of cancer prevention : APJCP, 2010
Very little epidemiological data regarding bone sarcomas from South Asia in general and Pakistan in particular are available. At the largest center for histopathology in Pakistan, we looked at three common bone sarcomas in our practice i.e. osteosarcoma, Ewing's sarcoma and chondrosarcoma. Our aim was to compile epidemiological data regarding age, gender and site distribution, and to correlate our findings with published western data in order to determine whether there were any significant differences in our population compared to the west. An overwhelming majority of osteosarcomas in our study occurred in the second and third decades of life; they were common in males; and femur, tibia and hip bone were the commonest bones involved accounting for an overwhelming majority of cases. The large majority of Ewing's Sarcomas in our study occurred in the first three decades of life; they were more common in males; vertebrae, tibia, femur and hip bone were the commonest sites. In o...
Incidence of bone tumors and tumor like lesions at a tertiary centre - a study of 64 cases
International Journal of Research in Medical Sciences, 2018
Background: Primary bone tumors are uncommon lesions constituting less than 1% of all cancers. Although open biopsy has high accuracy, it increases risk of tumor dissemination in patients with highly malignant tumors. FNAC eliminates the complications that may occur in surgical procedures and also gives quick results. This study was conducted to determine the spectrum and demographic characteristics of bone tumors and tumor like lesions at a tertiary care centre in western Uttar Pradesh and also to assess the role of FNAC in their diagnosis. Methods: This is a three-year, retrospective as well as a prospective study done on a total of 64 cases. All the cases were subjected to detailed history, physical examination and radiological investigations. FNAC smears were stained with Giemsa and Papanicolaou stain. H and E staining was done for histopathology. Results: Mean age affected was 26 years. Male-female ratio was 2.8:1. Out of total 64 cases of bone tumors and tumor like lesions, maximum was chondrogenic tumors (17; 26.56%), followed by osteogenic tumors (15; 23.44%). Osteochondroma (08; 47.06%), Osteosarcoma (07; 46.66%) and Aneurysmal bone cyst (04; 50.0%) were the most common chondrogenic tumor, osteogenic tumor and tumor like lesion respectively. The most common bone affected was tibia (16; 25.0%), followed by femur (15; 23.4%). Sensitivity and specificity of FNAC as a diagnostic modality were 90.0% and 91.67% respectively. Conclusions: A good correlation is observed between cytological and histological diagnoses which implies that FNAC can be used as a preliminary diagnostic approach to bone tumors, although histopathology remains the gold standard.
Histomorphological Spectrum of Bone Lesions at Tertiary Care Centre
Background: The spectrum of pathological bone lesions ranges from inflammatory to neoplastic conditions. Bone tumours are comparatively uncommon among wide array of lesions. The roentgenogram helps in defining exact location of lesion but becomes difficult to differentiate them. They often pose diagnostic problem as they constitute a small portion of diagnostic experience among pathologist. Objective: To study histopathological spectrum of bone lesions & correlate them with age, gender and site of occurrence. Results: All bone biopsies from January 2011 to December 2015 received at department of pathology, S.Nijalingappa Medical College, India. Total 121 cases of bone biopsies were analysed. They were decalcified & processed routinely. Out of 121 bone biopsies, 35 (28.9%) cases are non-neoplastic, 77 (63.6%) are neoplastic and 9 (7.4%) were inadequate for evaluation. The incidence of benign lesions are more than malignant with 51(66.2%) and 26(33.7%) cases respectively. Chronic osteomyelitis is the most common non-neoplastic lesion. Giant cell tumor and osteosarcoma are common benign and malignant lesions respectively. Femur is the common bone involved and metaphysis, the commonest site. The maximum numbers of cases are in the age group between 11-30 years with male preponderance. Conclusion: Though bone lesions are less common, if viewed in perspective of clinico-radiology and histopathology, correct diagnosis can be reached.
Clinicopathological Correlation of Primary Malignant Bone Tumors—An Observational Study
Open Journal of Orthopedics, 2015
Background: Primary malignant tumors arising from bone are uncommon but important malignant neoplasms which account for 0.2% of all primary cancers in adults and approximately 5% of all childhood malignancies. Aim: No comprehensive surveillance data about primary malignant bone tumors is available from this region of West Bengal in the literature. An attempt is undertaken to correlate clinicopathological findings, both histological & cytological features of primary bone tumours. Method: This observational study of clinical presentation was corroborated with cytology and histopathology of 67 cases of primary malignant bone tumors in 2005-2007 in a tertiary health care centre. Results: Among the primary malignant tumors, 39 cases (58.20%) were male and 28 (41.80%) were female. Sixty one lesions (91%) were located in the long bones and 6 (9%) involving flat and short bones. Osteosarcomas are found to be the predominant primary malignant bone tumors (44.77%), followed by Ewing's sarcomas (20.89%), chondrosarcomas (13.43%), high grade giant cell tumor, and plasmacytoma (5.97%). Predilection for male (M: F 2:1) found in both osteosarcoma and chondrosarcoma, but it was reverse in cases of Ewing's sarcomas. Conclusion: Osteosarcoma is the most common around knee joint and chondrosarcoma is frequent in long bones in this region. We made an attempt to correlate FNAC findings with the histopathology and it was seen that overall sensitivity of FNAC of primary malignant bone tumors was 56.71%.