Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes (original) (raw)

Dengue is the most prevalent arboviral disease in humans, necessitating an understanding of the transmission dynamics between symptomatic dengue cases and Aedes aegypti mosquitoes. This study examined how host and viral factors affect the transmission risk of dengue virus (DENV) by analyzing data from 208 symptomatic dengue patients across 407 exposure events. Key findings include that higher DENV plasma viremia levels are associated with increased risk of transmission to mosquitoes, while declining viremia and rising antibody titers inherently reduce this risk. The research highlights the importance of specific viremia levels necessary for effective vaccine and antiviral drug development.