Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol (original) (raw)
Identification of novel mPGES-1 inhibitors through screening of a chemical library
Hafiz Muhammad Ahsan
Bioorganic & Medicinal Chemistry Letters, 2012
View PDFchevron_right
Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E 2 Synthase-1 (mPGES-1)
Patrick Markt
Journal of Medicinal Chemistry, 2011
View PDFchevron_right
A multi‐step virtual screening protocol for identification of novel non‐acidic microsomal prostaglandin E2 synthase‐1 (mPGES‐1) inhibitors
Tansu Yalçın
ChemMedChem, 2018
View PDFchevron_right
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme
Isabel Gomez Monterrey
ChemMedChem, 2016
View PDFchevron_right
Toward the Discovery of New Agents Able to Inhibit the Expression of Microsomal Prostaglandin E Synthase-1 Enzyme as Promising Tools in Drug Development
Maurizio Aquino
Chemical Biology & Drug Design, 2010
View PDFchevron_right
Toward the Discovery of New Agents Able to Inhibit the Expression of Microsomal Prostaglandin E Synthase1 Enzyme as Promising Tools in Drug Development: Inhibitors of Microsomal Prostaglandin E Synthase1 Expression
Maria Graciela Sandoval Guerrero
Chemical Biology & Drug Design, 2010
View PDFchevron_right
ARTICLE pubs.acs.org/jmc Pharmacophore Modeling and Virtual Screening for Novel Acidic
Daniela Schuster
2013
View PDFchevron_right
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4- d ]imidazole derivatives as microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model
jitendra gajera
Bioorganic & Medicinal Chemistry Letters, 2017
View PDFchevron_right
Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2
Abhay Kulkarni
Bioorganic & medicinal chemistry letters, 2018
View PDFchevron_right
Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia Running Title a. Running Title: Novel mPGES-1 inhibitors for Analgesia
Thomas Seng
2020
View PDFchevron_right
Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors
Marina Korotkova, Per-johan Jakobsson
Basic & Clinical Pharmacology & Toxicology, 2014
View PDFchevron_right
Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase-1 Using Pharmacophore Models
Stefan Noha
ChemMedChem, 2012
View PDFchevron_right
Pharmacoinformatics approach for mPGES-1 in anti-inflammation by 3D-QSAR pharmacophore mapping
Calvin Chen
Journal of The Taiwan Institute of Chemical Engineers, 2009
View PDFchevron_right
Targeting inflammation: multiple innovative ways to reduce prostaglandin E2
Emmanuelle Meuillet
Pharmaceutical Patent Analyst, 2013
View PDFchevron_right
In Silico Discovery of Potential Azole-Containing mPGES-1 Inhibitors By Virtual Screening, Pharmacophore Modeling and Molecular Dynamics Simulations
Ayşe Ogan
2022
View PDFchevron_right
Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia
Thomas Seng
Journal of Pharmacology and Experimental Therapeutics, 2016
View PDFchevron_right
Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1
Sven-Christian Pawelzik, Ralf Morgenstern
Biochemistry, 2011
View PDFchevron_right
Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review
Yogesh Katare
Current Medicinal Chemistry, 2009
View PDFchevron_right
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1
Abhay Kulkarni
Bioorganic & medicinal chemistry letters, 2017
View PDFchevron_right
Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1*
Leotrim Spahiu
2010
View PDFchevron_right
Human microsomal prostaglandin E synthase-1 (mPGES-1) binding with inhibitors and the quantitative structure-activity correlation
Assou Hamza
2008
View PDFchevron_right
In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase1
Ian Humphery-smith, Oleg Demin, Alexey Goltsov
Pharmaceuticals, 2010
View PDFchevron_right
Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics
Charles Serhan
Proceedings of the National Academy of Sciences, 2003
View PDFchevron_right
Amide Hydrolysis of a Novel Chemical Series of Microsomal Prostaglandin E Synthase-1 Inhibitors Induces Kidney Toxicity in the Rat
Håkan Andersson
Drug Metabolism and Disposition, 2013
View PDFchevron_right
Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions
Ravi Kurumbail, Hideji Fujiwara
Journal of Computer-Aided Molecular Design, 2009
View PDFchevron_right
A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E 2 synthase
Ralf Morgenstern
Proceedings of the National Academy of Sciences of the United States of America, 2016
View PDFchevron_right
Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues
Zisis Peitsinis
The Journal of Organic Chemistry, 2018
View PDFchevron_right
Modified Acidic Nonsteroidal Anti-Inflammatory Drugs as Dual Inhibitors of mPGES-1 and 5-LOX
Mahmoud Elkady
Journal of Medicinal Chemistry, 2012
View PDFchevron_right
Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1
KyungBo Kim
Bioorganic & medicinal chemistry letters, 2018
View PDFchevron_right
Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases
Parthasarathy Chandrakesan
Journal of Inflammation Research, 2020
View PDFchevron_right