A Gate in the Selectivity Filter of Potassium Channels (original) (raw)

bent at a conserved glycine residue acting as a hinge (Jiang et al., 2002), presents a general paradigm for 1 Department of Physiology and Biophysics such a gating mechanism. Although this is less well Weill Medical College of Cornell University understood, several lines of evidence suggest that the 1300 York Avenue opening and closing of K + channels may implicate the New York, New York 10021 selectivity filter itself (i.e., that the selectivity filter might have the ability to act as a gate by switching between conducting and nonconducting states).